Cutaneous Metastasis as a Presenting Feature of Renal Adenocarcinoma in a Renal Transplant Recipient: A Case Report

Bašić‐Jukić, Nikolina; Mesar, Ines; Kirincich, Jason

doi:10.1016/j.transproceed.2019.04.021

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…[9][10][11] However, some examples with distant metastasis are reported but none of them into the renal allograft. 9,[11][12][13][14][15][16] Also, tumours of other origin than kidney seem to rarely metastasize into the allograft in kidney transplant recipients. We could only find one single report of a metastatic allograft lesion originating from a urothelial carcinoma of the recipient.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Translocated Renal Cell Carcinoma in a Kidney Transplant Patient - a Case Report and Review of the Literature

et al. 2023

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TFEB-altered renal cell carcinomas are rare tumours. Here, we report the exceptional case of such a tumour in the setting of solid organ transplantation and with already metastatic disease at the time of diagnosis. The primary tumour occurred in the native kidney and only focally showed biphasic morphology whereas the metastasis, among others to the transplant kidney, showed nonspecific, albeit different morphology, but both had consistent TFEB translocation. Treatment with the immune checkpoint inhibitor pembrolizumab together with the multi-kinase inhibitor lenvatinib achieved partial response 14 months after diagnosis.

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Section: Discussionmentioning

confidence: 99%

Metastatic Translocated Renal Cell Carcinoma in a Kidney Transplant Patient - a Case Report and Review of the Literature

et al. 2023

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“…The bibliographies of the remaining results were analysed to look for additional relevant cases. In total, there were 25 reported cases of soft tissue metastasis as the first presentation of RCC found 11–22…”

Section: Discussionmentioning

confidence: 99%

Isolated soft tissue mass of the finger as the first presentation of oligometastatic renal cell carcinoma

et al. 2022

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A man in his 70s was referred to plastic surgery with a suspected foreign body in the pulp of his right index finger. An excisional biopsy was performed for a presumed foreign body granuloma. Histology revealed metastatic renal cell carcinoma (mRCC). CT imaging demonstrated a 7.4 cm heterogeneous mass arising from the upper pole of the left kidney consistent with primary renal malignancy, in addition to a 9 mm lung nodule. He underwent an uncomplicated left laparoscopic cytoreductive nephrectomy and made a satisfactory recovery. To our knowledge, this is the first reported case of primary mRCC presenting with digital soft tissue metastasis. Cytoreductive nephrectomy with metastasectomy is the preferred management for mRCC where feasible. For unfavourable mRCC cases, first-line systemic therapy is indicated. Adjuvant systemic therapy in mRCC is currently limited to clinical trials, though promising data emerging on the use of pembrolizumab may herald a future shift in practice.

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“…(20) La decisión terapéutica es individualizada y requiere de manejo multidisciplinario dependiendo el estadio, la extensión y el estado funcional del paciente en cuestión, como podemos observar en la Tabla 1 donde se presenta el manejo de las metástasis cutáneas por cáncer renal en casos reportados de 2015 a 2020 y su evolución posterior. (3,(16)(17)19,(21)(22)(23)(24)(25)(26)(27)(28) Debido a que se trata de una entidad rara, nos encontramos ante pocos datos sobre el manejo óptimo de estos pacientes, encontrándose que en la actualidad no existe un tratamiento estándar o de primera línea para pacientes con sRCC. (29) La diferenciación sarcomatoide presenta pobre respuesta a tratamientos actualmente empleados, como el sunitinib, al compararlo con carcinomas renales sin este tipo de diferenciación incluso en estadios avanzados.…”

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Sarcomatoid renal cancer with multiple cutaneous metastases

et al. 2020

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Descripción del caso clínico: Masculino de 47 años que presentó lesiones cutáneas nodulares rojo-violáceas en cara, cuero cabelludo y manos, biopsia con reporte de metástasis de tumor renal. Estado general conservado, masa palpable abdominal y microhematuria. Tomografía reportó tumor renal derecho infiltrando grasa perirrenal. Se realizó nefrectomía radical derecha, reporte histopatológico tumor de células claras con 60% de componente sarcomatoide. Inició sunitinib con involución de las lesiones cutáneas, tras 2 semanas de intermitencia presentó recurrencia modificándose la dosis. Tres meses después presentó actividad metastásica cerebral, hepática y ósea evolucionando tórpidamente, falleciendo a cinco meses del diagnóstico. Relevancia: Particularmente nuestro caso no solo presenta una forma infrecuente de metástasis de cáncer renal recidivante a pesar del tratamiento con inhibidores de la tirosincinasa, sino también diferenciación sarcomatoide, una variante muy agresiva de cáncer renal. Implicaciones clínicas: Las metastásis cutáneas de cáncer renal presentan una incidencia aproximada de 3%, si bien no es de buen pronóstico encontrarlas, su detección oportuna es primordial en todo paciente. Conclusiones: El carcinoma renal sarcomatoide es un tumor raro y de pronóstico sombrío, generalmente asociado a metastásis a distancia. Es necesaria la valoración cutánea completa de todo paciente diagnosticado con cáncer renal para el adecuado estadiaje y tratamiento.

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Cutaneous Metastasis as a Presenting Feature of Renal Adenocarcinoma in a Renal Transplant Recipient: A Case Report

Cited by 4 publications

References 9 publications

Metastatic Translocated Renal Cell Carcinoma in a Kidney Transplant Patient - a Case Report and Review of the Literature

Metastatic Translocated Renal Cell Carcinoma in a Kidney Transplant Patient - a Case Report and Review of the Literature

Isolated soft tissue mass of the finger as the first presentation of oligometastatic renal cell carcinoma

Sarcomatoid renal cancer with multiple cutaneous metastases

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