Cutaneous metastasis in prostatic carcinoma

Pal, Devender; Talwar, Vineet; Doval, DC; Jalpota, YP; Kumar, Neeraj

doi:10.4103/0378-6323.51274

Cited by 9 publications

(8 citation statements)

References 6 publications

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“…Although rare, cytology of cutaneous metastasis of PA has been reported. [ 2 3 Cytological examination of PA shows scattered malignant cells with formation of glands at places and cells showing hyperchromatic nuclei and prominent nucleoli. Histopathogical examination of cutaneous metastases often involves dermis with sparing of the superficial dermis from the epidermis forming grenz zone.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous metastases of prostatic adenocarcinoma

Patne

Naik

Patnaik

et al. 2015

J Cytol

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Prostatic adenocarcinoma (PA) is a common visceral malignancy of elderly men. Cutaneous metastasis of PA is rare. The incidence is <1%. A 55-year-old man presented with urinary symptoms and multiple cutaneous nodules around suprapubic region, inner aspect of both thighs and scrotum. Fine-needle aspiration cytology (FNAC) of cutaneous nodules was suggestive of metastatic adenocarcinoma. Skin and prostatic biopsies confirmed the cytological diagnosis. Serum level of prostate specific antigen was raised. Total prostatectomy revealed adenocarcinoma of Gleason's score 7 (3 + 4). Though rare, cutaneous metastases of PA must be known to cytopathologists. Meticulously performed FNAC in such cases may help in early diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…[ 1 ] Diagnosis of cutaneous metastasis of PA by fine-needle aspiration cytology (FNAC) has been rarely reported. [ 2 3 ] We herein report the rare cytodiagnosis of cutaneous metastases of PA in an elderly man.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous metastases of prostatic adenocarcinoma

Patne

Naik

Patnaik

et al. 2015

J Cytol

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“…In the above described patient with adenocarcinoma prostrate, multiple hard nodules were located in the thigh region along with indurated plaques. [910] Sclerodermatous lesions are rare and occur in cancers with desmoplastic stroma as in our patient. [11]…”

Section: Discussionmentioning

confidence: 80%

Tumor attributes predicting cutaneous metastatic destiny: A report of two interesting cases

et al. 2014

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Cutaneous metastases are the result of complex interaction between the tumor cells (“seed”) and the host environment (“soil”). Metastases to the skin can be an early sign of internal malignancy or represent recurrence of the primary tumor and portends a poorer prognosis. Invasion and metastasis are the hallmarks of on cogenesis. Skin is the largest organ in the body, but the incidence of metastases is low. With advances in molecular biology, factors responsible for the initiation and perpetuation of metastatic tumor cells at distant sites are being elucidated. The concept of “pre-metastatic niche” and interaction between various chemokines has given a new outlook in understanding the organ specificity of metastatic tumor cells. We present two cases of cutaneous metastases with interesting clinical findings correlating with its biologic subtypes.

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“…Our patient presented with CM to the anterior abdominal wall, and an extensive search for the primary source by various histopathological and radiological investigations pointed us to the CM as the presenting manifestation of prostate cancer. Cutaneous manifestations are associated with a poor prognosis[ 9 ] because of the presumed systemic involvement required to develop such overt metastatic disease. The mean survival time after diagnosis of CM has been calculated at 7 months.…”

Section: Discussionmentioning

confidence: 99%