Cutaneous metastasis of cholangiocarcinoma

Lee, Min; Liu, Bai-Long; Liu, Bin; Guo, Liang; Wang, Qiang; Song, Yanqiu; Dong, Lihua

doi:10.3748/wjg.v21.i10.3066

Cited by 21 publications

(31 citation statements)

References 22 publications

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“…Prolonged catheterisation, multiple catheters or manipulations, papillary histology and well-differentiated tumours were found to significantly predispose to catheter tract seeding. In 2015, Liu et al 17 reviewed the English literature and found 30 reported cases of cutaneous metastasis in hilar cholangiocarcinoma. Half of these cases occurred at the PTBD catheter site and two-thirds were solitary.…”

Section: Discussionmentioning

confidence: 99%

Isolated implant metastasis in chest wall due to seeding of transpleurally placed PTBD catheter tract in a case of hilar cholangiocarcinoma

Talukder¹,

Behera

Tandup

et al. 2017

BMJ Case Reports

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Percutaneous transhepatic biliary drainage (PTBD) catheter site metastasis in cases of cholangiocarcinoma is reported sporadically. But it is unusual to see left-sided tumour metastasising to the right PTBD catheter site. Metastasis, in general, has a poor prognosis, but recurrence along the catheter tract in the absence of other systemic diseases can be a different scenario altogether. To date, there is no consensus on the management of this form of metastasis. But carefully selected patients can benefit from aggressive surgical resection. We report a case of a young patient with isolated chest wall metastasis 1 year after resection of left-sided hilar cholangiocarcinoma. The metastasis was resected and, on pathological analysis, was confirmed to be due to implantation of malignant cells along the tract of the PTBD catheter placed via a transpleural route.

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Section: Discussionmentioning

confidence: 99%

Isolated implant metastasis in chest wall due to seeding of transpleurally placed PTBD catheter tract in a case of hilar cholangiocarcinoma

Talukder¹,

Behera

Tandup

et al. 2017

BMJ Case Reports

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“…Skin metastasis as the first sign of CC was seen in 27% cases in a study by Liu et al, [15]. Hence suggesting that bile duct examination should be performed for cutaneous metastasis of unknown origin.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Metastasis from Cholangiocarcinoma Presenting as Thigh Mass

Varma

Singh

Misra

2016

JCDR

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A 45-year-old man was admitted to our hospital with complains of weight loss, abdominal distension and a Painless subcutaneous nodule on his left thigh for 2 months. Apart from the presence of ascitis and subcutaneous nodule, the findings of the physical examination were normal. No icterus was present. Laboratory analysis showed the following results: Total Leukocyte count (TLC) 9,500/mm 3 , haemoglobin 7.6 gms/dL; Liver Function Test (LFT) showed: total bilirubin levels of 0.5 mg/dl, serum aspartate transaminase and alanine aminotransferase levels wee 256IU/L and 280 IU/L, alkaline phosphatase 332 IU/L.

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“…Cutaneous metastases of cholangiocarcinoma are extremely rare and have been reported to occur in only 0.4-5.3% of cases. 7 The latest systematic review was published in 2015 8 and reported 30 cases between 1978 and 2014. In this study, the median age at diagnosis was 60 years old.…”

Section: Discussionmentioning

confidence: 99%

“…7 Regarding distant sites, the most frequently involved is the scalp. 2,7,8 The incidence of cutaneous metastatic lesions as the first clinical sign of the cancer has been described in only 0.8% of the patients with systemic malignancies. 7 However, regarding cutaneous metastasis of cholangiocarcinoma, as in the case reported, the literature review shows an incidence of 27.6% 8 , suggesting that bile duct examination should be performed for cutaneous metastasis of unknown origin.…”

Section: Discussionmentioning

confidence: 99%

Cholangiocarcinoma Seeding along a Ventriculoperitoneal Shunt Catheter: A Rare Initial Manifestation

Morais

Iglesio

Petitto³

et al. 2017

Arq Bras Neurocir

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Cholangiocarcinoma accounts for less than 2% of all malignant neoplasms. Its cutaneous metastases are extremely rare, accounting for 0.0002% of all cases. The ventriculoperitoneal (VP) shunt has been considered a potential route for tumor dissemination. This type of tumor proliferation has been well documented in patients with intra-abdominal metastases secondary to brain tumors and, less frequently, brain metastases secondary to intra-abdominal tumors. In spite of that, there are few reports of cutaneous metastases along the VP shunt catheter trajectory. We present the case of a cholangiocarcinoma cutaneous metastasis at the VP shunt trajectory as the first clinical sign of this type of tumor. The patient had undergone the shunt insertion 4 years earlier due to a hydrocephaly secondary to a subarachnoid hemorrhage. After diagnosis, she was referred to chemotherapy and oncology follow-up. In the literature, 30 cases of cutaneous metastasis of cholangiocarcinoma were reported. Dissemination has been described involving percutaneous biliary drainage and distant sites. However, the case presented in this study alerts us about the possibility of cutaneous metastasis of intra-abdominal tumors in the trajectory of VP shunt catheters. ResumoO colangiocarcinoma representa menos de 2% das neoplasias malignas. Sua metástase cutânea é extremamente rara, representando 0.0002% dos casos. A derivação ventrículo-peritoneal (DVP) tem sido considerada uma via potencial para a disseminação dos tumores. Essa propagação tumoral já foi bem descrita em pacientes com tumores do sistema nervoso central e metástases intra-abdominais e, menos

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Cutaneous metastasis of cholangiocarcinoma

Abstract: The prognosis of cutaneous metastasis of cholangiocarcinoma is dismal. Both male gender and single skin metastasis are associated with a poorer OSCM.

Cited by 21 publications

References 22 publications

Isolated implant metastasis in chest wall due to seeding of transpleurally placed PTBD catheter tract in a case of hilar cholangiocarcinoma

Isolated implant metastasis in chest wall due to seeding of transpleurally placed PTBD catheter tract in a case of hilar cholangiocarcinoma

Cutaneous Metastasis from Cholangiocarcinoma Presenting as Thigh Mass

Cholangiocarcinoma Seeding along a Ventriculoperitoneal Shunt Catheter: A Rare Initial Manifestation

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