Cutaneous Metastasis of Rectal Cancer: A Case Report and Literature Review

Dehal, Ahmed; Patel, Sunal; Kim, Sean; Shapera, Emanuel; Hussain, Farabi

doi:10.7812/tpp/15-078

Cited by 36 publications

(42 citation statements)

References 20 publications

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“…The detection of cutaneous metastases portends a dismal prognosis with most patients dying in less than six months (2-4 months). When cutaneous metastases were seen, distant metastases were not documented in the liver or lungs of any patients although liver and pulmonary metastases were reported four months after the skin metastases in two patients [10,12]. Cutaneous metastases of rectal signet ring cell carcinoma displayed an atypical skin distribution with a high incidence on the face and upper body in most of the cases.…”

Section: Discussionmentioning

confidence: 89%

“…In another study of six patients with cutaneous metastases of rectosigmoid origin, all cutaneous metastases displayed the typical adenocarcinoma without any signet ring cell case [8]. In a literature review of 28 cases of cutaneous metastases adenocarcinoma from the rectum, Dehal et al identified only two definitive cases of rectal signal ring cell adenocarcinoma metastasizing to the skin [9]. Our own literature review via the PubMed search engine revealed only five histologically well-documented cases of metastatic signet ring cell carcinoma of rectal origin to the skin ( Further analysis of these cases revealed several additional interesting observations, including most patients were male (5:1) with a mean age of 53 years (range: 29-71 years).…”

Section: Discussionmentioning

confidence: 99%

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Most Common Pathway of Metastasis of Rectal Signet Ring Cell Carcinoma to the Skin: Hematogenous

Mandzhieva

Jalil

Nadeem

et al. 2020

Cureus

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Liver represents the most common site of metastasis in patients with advanced colorectal cancer (CRC). Cutaneous metastasis is uncommon and has been documented only in 3% of patients. Most cutaneous metastases demonstrate typical histological features of adenocarcinoma, such as glandular formation and mucin production. We present the case of a 66-year-old male with Crohn's disease (CD) and stage IV rectal signet ring cell carcinoma arising in his rectal stump who presented with a painful papular bilateral groin rash. Biopsy revealed metastatic signet ring cell carcinoma. Since cutaneous metastasis in patients with advanced CRC can be easily confused with infection, especially fungal infection, physicians should be vigilant of the possibility of cutaneous metastasis. Our literature review suggests hematogenous spread as the dissemination pathway of this histological subtype of rectal adenocarcinoma to the skin. We present the first case of cutaneous metastatic signet ring cell carcinoma from a rectal stump of a patient with CD.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Most Common Pathway of Metastasis of Rectal Signet Ring Cell Carcinoma to the Skin: Hematogenous

Mandzhieva

Jalil

Nadeem

et al. 2020

Cureus

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“…[8][9][10] Mucinous variant of rectal adenocarcinoma is found to be more likely associated with cutaneous involvement. 11 A large retrospective study conducted on 7316 cancer patients included 772 patients of colorectal cancer revealed that only 4 patients (.05 %) had cutaneous involvement at the time of diagnosis. 7 Another study included 4020 patients with metastatic disease, 18 (4.4 %) out of 413 patients of metastatic colon cancer had skin metastasis.…”

Section: Discussionmentioning

confidence: 99%

A peculiar case of cancer en cuirasse in adenocarcinoma rectum

et al. 2020

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Cancer en cuirasse in a case of primary adenocarcinoma rectum is an exceedingly rare phenomenon which is scarcely seen in isolated case reports only. It is a specific morphological variant of cutaneous metastasis characterised by diffuse induration and oedema of cutis which is studded with carcinomatous lesions. Cutaneous metastases often occur in elderly individuals in their sixth decade or later. Herein we present a case of carcinoma en cuirasse arising in a young female who was operated for adenocarcinoma rectum.

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“…Visceral cancer metastasis to the skin is often associated with a poor prognosis. Dehal et al (11) reported a mean recurrence time of cutaneous metastasis from rectal adenocarcinoma of 18 months and a mean survival of �10 months after the appearance of metas-�10 months after the appearance of metas-10 months after the appearance of metastases (median, 4 months; range, 1-56 months). On average, cutaneous metastasis is reportedly associated with a survival of 7.5 months following the diagnosis of cancer (12).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous and breast metastasis from colorectal adenocarcinoma: A rare case report

et al. 2019

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Synchronous breast and cutaneous metastases from colorectal adenocarcinoma as the initial clinical manifestation, without visceral metastases, are extremely rare. We herein report the case of a 68-year-old female patient who presented with pruritic skin lesions and a breast lump 6 years after abdominoperineal resection of colorectal adenocarcinoma. Such cases can be easily misdiagnosed as cutaneous metastasis from breast cancer. However, the management of colorectal metastases differs from that of primary breast cancer, and mastectomy may be unnecessary. Timely and accurate diagnosis requires a high level of suspicion, thorough medical clinical history and biopsy followed by immunohistological examination. Specific immunohistochemical markers, such as cytokeratin (CK)7, CK20 and CDX2, may help differentiate between primary breast and metastatic colorectal adenocarcinoma.

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Cutaneous Metastasis of Rectal Cancer: A Case Report and Literature Review

Cited by 36 publications

References 20 publications

Most Common Pathway of Metastasis of Rectal Signet Ring Cell Carcinoma to the Skin: Hematogenous

Most Common Pathway of Metastasis of Rectal Signet Ring Cell Carcinoma to the Skin: Hematogenous

A peculiar case of cancer en cuirasse in adenocarcinoma rectum

Cutaneous and breast metastasis from colorectal adenocarcinoma: A rare case report

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