Cutaneous metastasis of signet cell gastric carcinoma

Çokgezer, Simay; Samancı, Nilay Şengül; Bektas, Mert; Kepil, Nuray; Demirelli, Fuat

doi:10.4103/ijd.ijd_263_18

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…The clinical manifestations of SRCC cutaneous metastases have been reported as papulonodular, erythematous plaque, as well as scar-and erysipelas-like lesions. 3,4 This case in this study showed a rare signet-ring cutaneous metastasis presenting with lesions that imitate the shape of huge bunches of grapes, which has not been described throughout the literature, to the best of our knowledge. In our cases speculated the route of cutaneous metastasis of visceral tumors was via lymphatic vessels.…”

Section: Discussionmentioning

confidence: 58%

Signet-Ring Cutaneous Metastasis Presenting with Huge Bunches of Grapes

Hao¹,

Deng²,

He³

et al. 2022

CCID

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Signet-ring cell (SRC) is a histologic type in which cells show unique features under the microscope. We mainly found signet-ring cells (SRCs) in gastrointestinal and breast tumors. Cutaneous metastasis from internal carcinomas was an uncommon presentation. The cases of signet-ring cell carcinoma (SRCC) metastasis to the skin were rarely reported. Cutaneous metastasis indicated a poor prognosis for a patient. Here, we report a female who had huge grape-like nodules arising from gastrointestinal SRCC in her trunk and thigh.

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Section: Discussionmentioning

confidence: 58%

Signet-Ring Cutaneous Metastasis Presenting with Huge Bunches of Grapes

Hao¹,

Deng²,

He³

et al. 2022

CCID

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“…Thirty percent of the patients presented with cutaneous lesions and advanced gastric cancer synchronously while 70% developed cutaneous metastases 1.3 years to 14 years after the initial treatments of primary gastric cancer. Interestingly, 80% of the patients received some sort of management approach ranging from local excision to chemo or chemo-radiation therapy to treat their cutaneous metastases[ 9 - 15 ].…”

Section: Discussionmentioning

confidence: 99%

Extensive cutaneous metastasis of recurrent gastric cancer: A case report

Zheng

Lin

2021

WJCC

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BACKGROUND Cutaneous metastasis is a rare event associated with poor prognosis for gastric cancer and has been rarely reported in the literature. CASE SUMMARY A 69-year-old male patient who had undergone salvage gastrectomy and a few courses of adjuvant chemotherapy 3 mo earlier for recurrent gastric cancer developed widespread cutaneous metastases. Due to the patient’s intolerance to further adjuvant chemotherapy, he was placed in hospice care and expired 1 mo later. In the literature, gastric cancers are rarely reported as the primary malignancies for cutaneous metastasis. We, thus, provide an update on a case review published in 2014 by reviewing 10 more case reports dated from 2014 to 2020. The average age for the new group of patients was 59.4 ± 18.88-years-old. Thirty percent of the patients presented with cutaneous lesions and advanced gastric cancer synchronously while 70% developed cutaneous metastases 1.3 years to 14 years after the initial treatment for primary gastric cancer. Eighty percent of the patients received either local excision or chemo ± radiation therapy to treat their cutaneous metastases. CONCLUSION This report highlights cutaneous metastasis as a late and untreatable metastasis of gastric cancer.

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“…Comumente, as manifestações cutâneas se apresentam tardiamente, como visto no presente relato, mas também evidenciado por outros pesquisadores (Cokgezer et al, 2020;Rakka et al, 2019;Yang et al, 2020). De acordo com Rakka et al (2019), as metástases cutâneas de CG são inoperáveis e estão associadas a um estágio avançado da doença.…”

Section: Discussionunclassified

“…De acordo com estudo de caso apresentado por Cokgezer et al (2020), em que uma paciente de 75 anos previamente submetida a gastrectomia total associada à linfadenectomia D2 associada a quimioterapia e radioterapia adjuvantes, devido a um adenocarcinoma gástrico de células em anel de sinete, observou-se o aparecimento de uma lesão de aspecto cicatricial em região epigástrica após três anos do diagnóstico inicial, a qual foi submetida a biópsia e confirmada a presença de células em anel de sinete, permitindo fechar o diagnóstico para carcinoma metastático de células em anel de sinete. Para o tratamento metastático, foi iniciado novo ciclo de quimioterapia com 5-fluorouracil e oxaliplatina.…”

Section: Discussionunclassified

“…No que tange à condução terapêutica dos casos de metástases cutâneas, não há dentre os estudos apresentados uma homogeneidade, visto que existiram estudos com abordagem quimioterápica exclusiva, como realizado no presente estudo (Cokgezer et al, 2020;Yang et al, 2020), mas também houve reporte da associação de quimioterapia com a abordagem cirúrgica (Namikawa et al, 2017).…”

Section: Discussionunclassified

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Apresentação atípica de metástase de adenocarcinoma gástrico: relato de caso

Linhares

Assis

Salge

et al. 2021

RSD

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Introdução: O câncer gástrico é o 5º câncer mais incidente, excetuando-se tumores de pele não melanoma e a 3ª causa de morte decorrente de câncer no mundo. Os locais mais comuns de metástases do câncer gástrico são: fígado (48%), peritônio (32%), pulmão (15%) e osso (12%). Objetivo: apresentar o curso de metástase cutânea em decorrência de um adenocarcinoma gástrico. Metodologia: Estudo descritivo do tipo relato de caso, cujos dados foram obtidos no prontuário físico da paciente. Apresentação do caso: Reportamos o caso de uma paciente do sexo feminino, 44 anos, submetida a tratamento cirúrgico e quimioterápico devido a um adenocarcinoma gástrico. Um ano e quatro meses após a intervenção inicial, observou-se o aparecimento de lesões cutâneas hipercrômicas, dolorosas, difusas e não pruriginosas, localizadas principalmente em tórax, dorso e membros superiores. A biópsia cutânea confirmou a hipótese de metástase cutânea de adenocarcinoma gástrico. Conclusão: No contexto do tratamento do câncer gástrico, faz-se importante a vigilância de novos sinais e sintomas, como lesões cutâneas insidiosas, aventando a possibilidade de tumor cutâneo metastático.

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Cutaneous metastasis of signet cell gastric carcinoma

Cited by 8 publications

References 9 publications

Signet-Ring Cutaneous Metastasis Presenting with Huge Bunches of Grapes

Signet-Ring Cutaneous Metastasis Presenting with Huge Bunches of Grapes

Extensive cutaneous metastasis of recurrent gastric cancer: A case report

Apresentação atípica de metástase de adenocarcinoma gástrico: relato de caso

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