Cutaneous metastasis to the scalp as the primary presentation of colorectal adenocarcinoma

Shah, Sarita R.; Applebaum, Danielle S.; Potenziani, Silvia; Huttenbach, Yve; Wolf, John E.; Orengo, Ida

doi:10.5070/d32311037274

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…However, some CMs occurred in regions distant from the primary tumors; for example, the scalp was a common CM location for various tumors. The possible mechanism as to why the scalp is a common destination for CM is thought to be due to its high vascularity [19].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic features of cutaneous metastases from internal malignancies

Kwon

Kim

Shin

et al. 2021

J Pathol Transl Med

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Background: Cutaneous metastasis (CM) is the spread of cancer cells from a primary site to the skin and is rarely the first sign of silent cancer. We investigated the clinicopathological characteristics of CM from internal malignancies in Korean patients treated at our institution over 20 years. Methods: The clinicopathological findings of 112 patients (62 females, 50 males) with CM diagnosed at Yeungnam University Hospital between 2000 and 2020 were retrospectively reviewed. Results: Mean patient age was 58.6 years (range, 26 to 87 years), and the most common primary cancer site was breast (74.2%) in women and lung (36.0%) in men. Ninety-six patients (85.7%) presented with CM after primary tumor diagnosis. CM from the lung or biliary tract usually occurred within 2 years of primary tumor diagnosis, whereas metastases from the breast and kidney occurred several years later. The chest, abdomen, and scalp were common sites of CM. Breast cancer usually metastasized to chest skin, while gastrointestinal tract cancers commonly metastasized to the abdomen. The scalp was a common location for CM from various tumors. The most common dermatologic presentations were nodules and masses. Immunohistochemical studies helped identify underlying malignancies when primary tumors were unknown.Conclusions: The relative frequency of CM parallels the overall incidence of primary malignant tumors, and CMs usually occur at anatomic sites close to the primary tumor. CM can be diagnosed based on clinical, radiological, and histological features; however, immunohistochemical study is required in some cases.

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Section: Discussionmentioning

confidence: 99%

Clinicopathologic features of cutaneous metastases from internal malignancies

Kwon

Kim

Shin

et al. 2021

J Pathol Transl Med

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“…В большинстве случаев метастазы в кожу располагаются в непосредственной близости от злокачественной опухоли. Таким образом, рак молочной железы чаще всего метастазирует в кожу области грудной клетки, рак кишечника и почек -в кожу брюшной стенки и промежности [5]. Иногда почечно-клеточный рак может давать метастазы в область головы при помощи обратного тока через сплетение Бэтсона -в позвоночные и далее в эмиссарные вены черепа [6].…”

Section: Introductionunclassified

Review of clinical cases of internal organ metastases into the skin of the head and neck

Kretova,

Nazarko,

Kopeikina

et al. 2023

Opuholi golovy i šei

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Metastases of malignant tumors of the internal organs into the skin rarely occur, on average in 1–10 % of cases. They can be the first manifestation of malignant process in the absence of signs of the main disease or show progression of confirmed cancer. The article presents clinical cases of metastases of renal cell carcinoma and adenocarcinoma into the skin of the head and neck which currently is rare. Skin metastases are variable in their clinical manifestation. In the presented cases, resection of the lesions was required as symptomatic treatment.

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Cutaneous metastasis of ascending colon cancer harboring a BRAF V600E mutation

et al. 2020

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Rationale: Cutaneous metastases from colorectal cancer are extremely rare and generally appear several years after diagnosis or resection of the primary colorectal tumor. Although cutaneous metastasis is unusual, it often indicates a poor prognosis. Patient concerns: We treated a 62-year-old woman with multiple cutaneous metastatic nodules on the chest, back, and armpit 7 months after resection of ascending colon cancer. Diagnoses: The patient was diagnosed with cutaneous metastasis of ascending colon cancer with BRAF V600E mutation. Interventions: After 6 cycles of fluorouracil, leucovorin, oxaliplatin, cetuximab, and emurafenib, most of the metastatic lesions had begun to shrink, and no new metastases were observed. Serum tests showed that the levels of several tumor markers were decreased. Outcomes: The patient responded well to treatment and survived for 6.5 months after presentation with skin metastasis. Lessons: Cutaneous metastasis of colorectal cancer with BRAF V600E mutation is a rare but important phenomenon that should not be ignored. Cutaneous metastasis of colorectal cancer frequently indicates advanced disease and poor prognosis. The SWOG 1406 program is one of the treatment options, but this needs further exploration.

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Cutaneous metastasis to the scalp as the primary presentation of colorectal adenocarcinoma

Cited by 5 publications

References 8 publications

Clinicopathologic features of cutaneous metastases from internal malignancies

Clinicopathologic features of cutaneous metastases from internal malignancies

Review of clinical cases of internal organ metastases into the skin of the head and neck

Cutaneous metastasis of ascending colon cancer harboring a BRAF V600E mutation

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