Cutaneous metastatic disease: Burkitt lymphoma

Rare Cutaneous Presentation of Burkitt Lymphoma

“…Cutaneous spread of Burkitt lymphoma is infrequently reported; all such reports that provide long-term follow-up data have described it in association with high disease burden and often a lethal outcome. 8,11,12 Our patient had complete resolution of cutaneous lesions with chemotherapy. It is unclear if the presence of cutaneous lesions can serve as a prognostic indicator and requires further investigation.…”

“…5,6 Extranodal metastasis is common, 7 but cutaneous involvement is exceedingly rare, with only a few cases having been reported. [8][9][10][11][12][13][14] Cutaneous metastasis of Burkitt lymphoma often is associated with a high overall disease burden and poor prognosis. 8,11 Immunodeficiency-related Burkitt lymphoma is particularly aggressive.…”

“…[8][9][10][11][12][13][14] Cutaneous metastasis of Burkitt lymphoma often is associated with a high overall disease burden and poor prognosis. 8,11 Immunodeficiency-related Burkitt lymphoma is particularly aggressive. Notably, 3 of 7 (42.9%) reported cases of cutaneous Burkitt lymphoma occurred in HIV-positive patients.…”

Other Cutaneous B‐Cell Lymphomas

“…Skin involvement represents almost invariably a secondary manifestation of the disease [29,30]. In rare cases of primary cutaneous diffuse large B-cell lymphoma, leg type, a Burkitt-like morphology may be observed, and these cases should be separated from genuine Burkitt lymphoma (see Chapter 13).…”

Epstein–Barr Virus in Cutaneous Pathology

“…219 Such a pattern led to the discovery of EBV by Epstein et al 220 in 1964. 223 221 In the pathogenesis of BL, age at infection with EBV and the ability to control the infected cells seems to be determinant.…”