Cutaneous Mucormycosis of the Upper Extremity in an Immunocompetent Host: Case Report

Lineberry, Kyle; Boettcher, Adam K.; Blount, Andrew L.; Burgess, Scott D.

doi:10.1016/j.jhsa.2011.11.010

Cited by 19 publications

(20 citation statements)

References 17 publications

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“…Cutaneous mucormycosis usually results from inoculation of the spores into the dermis. Innoculum could entre site from disruption of local defense mechanisms like burns, trauma, surgery, arterial lines, insulin injection sites, biopsy site, contaminated splints, dressings, tattoos and insect bites [8][9][10][11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Suspect the Unsuspected: An Unusual Case of Primary Cutaneous Mucormycosis at a Peripheral Intravenous Catheter Insertion Site. A Case report and Literature review

Yeruva

Kodadhala

et al. 2017

JBMOA

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Fungal Infections can have atypical presentation. This makes the diagnosis of fungal infections very challenging and in many cases increases morbidity and in unfortunate cases causes' mortality. Mucormycosis is a rare fungus which can present with wide clinical spectrum and can mislead as other etiologies. This fungus manifests itself mostly in immune compromised hosts. High index of suspicion is needed for accurate diagnosis. Prompt treatment includes combination of surgical debridement and antifungals. Early diagnosis and initiation of appropriate management can significantly decrease morbidity and mortality. Histological diagnosis is the only means of confirming mucormycosis infection. Our case is a typical example of atypical presentation of mucormycosis in an immune compromised patient which resulted in limb amputation

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Section: Discussionmentioning

confidence: 99%

Suspect the Unsuspected: An Unusual Case of Primary Cutaneous Mucormycosis at a Peripheral Intravenous Catheter Insertion Site. A Case report and Literature review

Yeruva

Kodadhala

et al. 2017

JBMOA

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“…1,3,4 Surgical debridement of all gangrenous tissue must be performed until healthy tissue is observed, and this may require several operations; however, complete surgical debridement sometimes may not be feasible because of the anatomic structures involved. 2,12 Despite treatment, the frequency of mortality from mucormycosis may be 60%. 1,4,6 In 1 study of 16 transplant patients who had mucormycosis, 10 patients (63%) survived after treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, cutaneous fungal infections should be considered in the differential diagnosis of any nonhealing infected wound that does not respond to broad-spectrum antibiotics, especially in patients who have predisposing risk factors such as transplant. 12 …”

Section: Discussionmentioning

confidence: 99%

“…6 The 5 main types of involvement include rhinocerebral (frequency, 39%), pulmonary (24%), cutaneous (19%), gastrointestinal, and disseminated. 5,12 The cutaneous type is rare but has the best survival when diagnosed early because cutaneous disease frequently may be resected completely. 4 Cutaneous mucormycosis may vary from a mild chronic infection to rapidly progressive disease.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, patients may have fever, severe pain, cutaneous erythema, cellulitis, vesicles, pustules, nodules, and lesions that appear similar to ecthyma gangrenosum. 4,11,12 Infection usually progresses rapidly because of fungal invasion and destruction of deep cellular layers. 7 The differential diagnosis of cutaneous mucormycosis includes ecthyma gangrenosum, pyoderma gangrenosum, vasculitis, and other fungal infections such as aspergillosis, histoplasmosis, and cryptococcosis.…”

Section: Introductionmentioning

confidence: 99%

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Davuodi

Manshadi²,

Salehi³

et al. 2015

Exp Clin Transplant

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Mucormycosis is an uncommon opportunistic infection that is caused by Mucorales from the Zygomycetes class. Patients with severe immunodeficiency admitted to the hospital are at greatest risk for developing this infection. Mucormycosis usually is transmitted in humans by inhalation or inoculation of spores in the skin or mucous membranes.A 66-year-old man developed a surgical wound infection at 1 week after kidney transplant that did not improve despite broad-spectrum antibiotics and debridement. He was transferred to our hospital 45 days after transplant and had fever and a large purulent wound that was surrounded by a black necrotizing margin. Immunosuppressive drugs were discontinued and the dosage of prednisolone was decreased. Massive debridement was performed but was incomplete because he had full-thickness abdominal wall necrosis. Histopathology showed broad fungal hyphae without septation, consistent with the diagnosis of mucormycosis. Despite antifungal therapy with amphotericin B and additional debridement, the patient died of septic shock at 52 days after kidney transplant.Cutaneous fungal infections should be considered in the differential diagnosis of any nonhealing infected wound that does not respond to broadspectrum antibiotics, especially in patients with predisposing risk factors such as transplant.

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The elusive nature of mucormycosis in an immunocompetent host and the role of a dermatology consult

Badin

Baker

Simmons

et al. 2019

Clinical Case Reports

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Cutaneous Mucormycosis of the Upper Extremity in an Immunocompetent Host: Case Report

Cited by 19 publications

References 17 publications

Suspect the Unsuspected: An Unusual Case of Primary Cutaneous Mucormycosis at a Peripheral Intravenous Catheter Insertion Site. A Case report and Literature review

Suspect the Unsuspected: An Unusual Case of Primary Cutaneous Mucormycosis at a Peripheral Intravenous Catheter Insertion Site. A Case report and Literature review

Untitled

The elusive nature of mucormycosis in an immunocompetent host and the role of a dermatology consult

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