Cutaneous Mycobacterium kansasii infection in a patient with systemic lupus erythematosus: Case report and review

Nontuberculous Mycobacteria

“…Disseminated disease can occur in immunosuppressed patients but it typically remains as a localized, indolent, lesion confined to the skin in the immunocompetent. 65 Cutaneous lesions can have a sporotrichoid distribution, 66 and present as nonhealing ulcers, nodules, and cellulitis. 67,68 Treatment with a variety of agents, including traditional antituberculous agents as well as erythromycin, minocycline, and doxycycline, has been successful.…”

Pediatric Cutaneous Nontuberculous Mycobacterium Infections in Singapore

“…The recommended duration of treatment for isolated cutaneous M. kansasii and M. avium intracellulare usually follows the recommended duration used to treat disseminated disease, which is at least 12 months (3,23). A case report of a patient with systemic lupus erythematosus taking immunosuppressants who had culture-confirmed isolated cutaneous M. kansasii showed resolution of symptoms after 5 months of rifampicin, isoniazid, and ethambutol, with a subsequent total duration of 18 months of treatment (24). In our study, the patient with systemic lupus erythematosus who was taking long-term immunosuppressants showed complete resolution after 4 months of the same antibiotic regimen.…”

Management of Extrapulmonary Nontuberculous Mycobacterial Infections

“…Most often RGM are the culprits in these instances, and they tend to present with multiple subcutaneous nodules that spontaneously drain. 28,[35][36][37][38][39] Several reports in the literature also support a relationship between disseminated M. kansasii infection and hairy cell leukemia. 40,41 In addition to antibiotic therapy, any effort to decrease immune-compromising medications should be pursued.…”