Cutaneous myoepithelioma: a clinicopathologic and immunohistochemical study of 14 cases

Hornick, Jason L.; Fletcher, Christopher D.�M.

doi:10.1016/j.humpath.2003.08.016

Cited by 180 publications

(291 citation statements)

References 32 publications

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“…2,3 They also include myoepithelial carcinomas, which are defined by atypical cytological features. 3,4 In the absence of atypia, high mitotic index, local invasion and tumor necrosis should raise concern. 4,8 Earlier studies suggested that cutaneous myoepitheliomas and their soft tissue counterparts represent points along a clinicopathological spectrum that was apparently extended to include myoepithelial tumors of the bone and of some visceral sites (lung).…”

Section: Discussionmentioning

confidence: 99%

“…3,4 In the absence of atypia, high mitotic index, local invasion and tumor necrosis should raise concern. 4,8 Earlier studies suggested that cutaneous myoepitheliomas and their soft tissue counterparts represent points along a clinicopathological spectrum that was apparently extended to include myoepithelial tumors of the bone and of some visceral sites (lung). 1,2,5,10 Although this entity, in the above described localizations, is well established by now, the protean morphological and immunohistochemical range is still hampering the histopathological diagnosis, and the true frequency of these neoplasms is unclear until today.…”

Section: Discussionmentioning

confidence: 99%

“…All these observations are well-reported earlier. [1][2][3][4]6 The occurrence of EWSR1 rearrangement in mixed tumors, myoepitheliomas and rare myoepithelial carcinomas emphasizes that these lesions belong to a spectrum of cutaneous myoepithelial neoplasms. …”

Section: Discussionmentioning

confidence: 99%

“…Although mixed tumors are not uncommon, purely myoepithelial tumors are very rare and only few and small series have been reported. [1][2][3][4] The presence of preexisting myoepithelial cells in the skin and viscera (eg, salivary glands, breast and lung) renders probably a pathogenetic difference with myoepithelial tumors of the soft tissue in which a normal counterpart does not exist.…”

mentioning

confidence: 99%

“…[1][2][3][4][5][6] Although criteria for malignancy in myoepithelial tumors of soft tissue have been established by moderate to severe nuclear atypia, the minimal criteria for malignancy among myoepithelial neoplasms of the skin remain uncertain. 4,6,7 Hornick and Fletcher 4 reported that increased mitotic activity (up to 6 mitoses/10 HPF) among cytologically benign cutaneous myoepitheliomas might predict recurrence and metastases. Furthermore, it has been suggested that in the absence of malignant cytomorphology and confirmed metastatic disease, infiltrative margins, satellite tumor nodules, tumor necrosis and involvement of deep structures are ominous signs.…”

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EWSR1 gene rearrangement occurs in a subset of cutaneous myoepithelial tumors: a study of 18 cases

et al. 2011

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Cutaneous myoepithelial tumors form a clinicopathological spectrum ranging from mixed tumor to myoepithelioma and myoepithelial carcinoma. Recently, EWSR1 rearrangement has been described in a subset of soft tissue myoepithelial tumors, whereas the cutaneous counterparts showed this aberration in a minority of cases. This raises the question whether cutaneous myoepithelial tumors have comparable genetic alterations. We examined 18 cases of cutaneous myoepithelial tumors arising in 7 female and 11 male patients (age range, 34-86 years; mean, 58 years). Eight mixed tumors occurred at the head, and one at the scrotum. Six myoepitheliomas arose at the extremities, and one case each at the back and head. One myoepithelial carcinoma occurred at the cheek. The tumor size ranged from 0.3 to 1.7 cm (mean, 1.0 cm). All mixed tumors and three myoepitheliomas were limited to the dermis. Four myoepitheliomas and the myoepithelial carcinoma involved the subcutis. Mixed tumors and myoepitheliomas were composed of myoepithelial cells with a variable cytomorphology, architecture and stromal background. Ductal structures were seen by definition in mixed tumors. The myoepithelial carcinoma represented an infiltrative dermal neoplasm consisting of atypical spindle cells. Immunohistochemically, all cases tested were positive for EMA and calponin, whereas S100, CK, ASMA and GFAP were expressed in 90%, 80%, 78% and 50% of the cases tested, respectively. By fluorescent in situ hybridization analysis, 7 out of 16 cases (44%) exhibited EWSR1 rearrangement. Four of them were mixed tumors, two were myoepitheliomas and one was a myoepithelial carcinoma, confirming that these lesions represent a spectrum of dermal myoepithelial tumors. Follow-up information, available for five patients (including the patient with a myoepithelial carcinoma), revealed no evidence of disease in all cases (range, 6-72 months). Our study provides a genetic relationship of myoepithelial tumors of the skin with their counterparts in soft tissue, bone and visceral localization by sharing EWSR1 rearrangement.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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EWSR1 gene rearrangement occurs in a subset of cutaneous myoepithelial tumors: a study of 18 cases

et al. 2011

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Tumours of Skin Appendages

Calonje

2016

Rook's Textbook of Dermatology, Ninth Edition

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This chapter on cutaneous appendageal tumours covers the spectrum of lesions displaying eccrine, apocrine, sebaceous and follicular differentiation. It includes cysts, hamartomas and benign and malignant tumours. Traditionally, appendageal tumours have been classified according to rigid criteria separating lesions with eccrine, apocrine, sebaceous and follicular differentiation. This separation is clearly artificial and it is now acknowledged that lesions regarded as strictly eccrine may well have apocrine differentiation and lesions classified as purely follicular may exhibit apocrine differentiation reflecting the close embryological relationship between the pilosebaceous unit and the apocrine gland.

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Tumours of Skin Appendages

Calonje,

Marušić

2024

Rook's Textbook of Dermatology

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The clinical presentation of skin appendage tumours for the most part is not as specific and diverse as the histological features of this extremely heterogeneous tumour group. Differential diagnosis of certain appendageal tumours can be extremely subtle, yet greatly influence final treatment outcome. Occasional association of certain entities with inherited tumour syndrome s can be extremely important in terms of hereditary cancer screening. This chapter aims to provide the most important clinical, histological and genetic features for selected, most important cutaneous appendage tumours.

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Cutaneous myoepithelioma: a clinicopathologic and immunohistochemical study of 14 cases

Cited by 180 publications

References 32 publications

EWSR1 gene rearrangement occurs in a subset of cutaneous myoepithelial tumors: a study of 18 cases

EWSR1 gene rearrangement occurs in a subset of cutaneous myoepithelial tumors: a study of 18 cases

Tumours of Skin Appendages

Tumours of Skin Appendages

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