Cutaneous Non-Hodgkin's Lymphoma of the Foot: A Rare Case Report

Ramanujam, Crystal L.; Lakhani, Shirmeen; Derk, Francis; Fulton, R. A.; Zgonis, Thomas

doi:10.1053/j.jfas.2009.05.002

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…The most common sites for the development of extranodal NHL include the gastrointestinal tract, followed by Waldeyer’s ring, lung, liver, spleen, bone, and skin [ 9 ]. As a subgroup of extranodal lymphoma, cutaneous extremity lymphoma is rarely reported in the literature [ 1 ]. Although skin infiltration occurs in 3% to 50% of patients with leukemias or lymphomas overall, it is rare in patients with CLL [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…In most observed cases, cutaneous lesions in CLL are an immune dysregulation phenomenon, rather than a direct infiltration by leukemic cells in the skin [ 10 ]. There are few reports of cutaneous symptoms being the primary manifestation of CLL and even fewer reports of primary NHL presenting in the foot in the biomedical literature [ 1 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…Non-Hodgkin’s lymphoma (NHL) is the most prevalent hematopoietic neoplasm worldwide [ 1 ]. It is observed more frequently in individuals aged over 75 years [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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A Rare Case of Recurrent Cutaneous Non-Hodgkin’s Lymphoma in the Extremity: Long-Term Follow-Up and Review of the Literature Written With the Assistance of ChatGPT

Dejong¹,

Gill²,

Lam³

et al. 2023

Cureus

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Cutaneous involvement of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is uncommon. We report on a 71-year-old male with a history of CLL of the skin in the distal extremities. The patient presented with eruptions of new lesions on the toes of his feet bilaterally, causing significant pain that limited his mobility. Cutaneous involvement of CLL is a rare presentation, and management recommendations are largely based on case reports with limited follow-up. Furthermore, assessing the duration of response, response rates, and correct sequencing of treatment is difficult due to variable use and doses of treatment. The case was treated in 2001 when newer systemic treatments were not available. Therefore, the results can also be directly related to local treatments. Based on a literature review and this case, this report provides insight into the benefits and risks of local treatment for cutaneous involvement of CLL in the extremities and how radiation can be sequenced with other options such as surgical excision and chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Recurrent Cutaneous Non-Hodgkin’s Lymphoma in the Extremity: Long-Term Follow-Up and Review of the Literature Written With the Assistance of ChatGPT

Dejong¹,

Gill²,

Lam³

et al. 2023

Cureus

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“…[6][7][8][13][14][15][16][17] Several other reports have identified the involvement of lymphoma of the ankle/foot joints, but not specifically in patients with known RA. [17][18][19][20][21][22] The only other reported case involving lymphoma of the ankle/foot joints in a patient with RA demonstrated a primary tumour of the synovium without bony involvement. 23 To the best of our knowledge this is the first case of a primary DLBCL of the joints of the mid and hind foot with underlying bone destruction in a patient with a background of RA.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Large B Cell Lymphoma of the Foot in a Patient with Rheumatoid Arthritis

Litwic¹,

Sampson

Foria³

et al. 2015

EMJ Rheumatol

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Patients with rheumatoid arthritis (RA) have an increased risk of developing malignant lymphomas, especially non-Hodgkin’s lymphoma (NHL). However, primary lymphoma in a joint is rare. Here we report a case of a 68-year-old man with a background of RA who presented with a 1-year history of pain and swelling in his right ankle. Initial imaging results comprised of X-ray and magnetic resonance imaging were inconclusive. Ultrasound scan of the right foot revealed a very large vascular mass with grossly eroded tarsal bones, and a biopsy confirmed the diagnosis of diffuse large B cell lymphoma. Involvement of lymphoma of ankle/foot joints is very rare: to our knowledge this is the first case of a primary diffuse large B cell lymphoma of the joints of the mid and hind foot with underlying bone destruction in a patient with a background of RA. This case is important because it highlights that malignancy should be suspected in every patient with a background of RA and unusual characteristics before assuming a diagnosis of flare of RA. This is important because early diagnosis of NHL can contribute to improved outcome.

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Concomitant Acute Osteomyelitis and Squamous Cell Carcinoma of the Foot: A Case Report

Kersh

Lakhani

Ramanujam

et al. 2010

Clinics in Podiatric Medicine and Surgery

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Cutaneous Non-Hodgkin's Lymphoma of the Foot: A Rare Case Report

Cited by 4 publications

References 8 publications

A Rare Case of Recurrent Cutaneous Non-Hodgkin’s Lymphoma in the Extremity: Long-Term Follow-Up and Review of the Literature Written With the Assistance of ChatGPT

A Rare Case of Recurrent Cutaneous Non-Hodgkin’s Lymphoma in the Extremity: Long-Term Follow-Up and Review of the Literature Written With the Assistance of ChatGPT

Diffuse Large B Cell Lymphoma of the Foot in a Patient with Rheumatoid Arthritis

Concomitant Acute Osteomyelitis and Squamous Cell Carcinoma of the Foot: A Case Report

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