2018
DOI: 10.1016/j.jdermsci.2018.07.008
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Cutaneous permeability barrier function in signal transducer and activator of transcription 6-deficient mice is superior to that in wild-type mice

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Cited by 6 publications
(4 citation statements)
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“…In Stat6 transgenic mice, the cutaneous expression of Lor and Ivl was shown to be significantly decreased compared with that in control wild-type mice [110]. In contrast, the permeability barrier function was found to be upregulated in Stat6-deficient mice with significantly increased Lor expression [139]. Moreover, the Flg and Ivl expression tended to be upregulated in Stat6-deficient mice, but this did not reach statistical significance [139].…”
Section: Downregulation Of Ivl Lor and Flg By Il-4/il-13mentioning
confidence: 92%
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“…In Stat6 transgenic mice, the cutaneous expression of Lor and Ivl was shown to be significantly decreased compared with that in control wild-type mice [110]. In contrast, the permeability barrier function was found to be upregulated in Stat6-deficient mice with significantly increased Lor expression [139]. Moreover, the Flg and Ivl expression tended to be upregulated in Stat6-deficient mice, but this did not reach statistical significance [139].…”
Section: Downregulation Of Ivl Lor and Flg By Il-4/il-13mentioning
confidence: 92%
“…In contrast, the permeability barrier function was found to be upregulated in Stat6-deficient mice with significantly increased Lor expression [139]. Moreover, the Flg and Ivl expression tended to be upregulated in Stat6-deficient mice, but this did not reach statistical significance [139].…”
Section: Downregulation Of Ivl Lor and Flg By Il-4/il-13mentioning
confidence: 93%
“…Findings have suggested that this is indeed the case. The skin barrier function in STAT6-deficient mice is significantly up-regulated compared with that in wild-type mice, as demonstrated by decreased TEWL, increased water content, decreased pH, decreased permeability of Evans blue, and increased LOR and FLG expression [108].…”
Section: Regulation Of Skin Barrier Function By Competition Between Ahr Axis and Il-13/il-4-jak-stat6/stat3 Axismentioning
confidence: 98%
“…IL-4/IL-13 signaling downregulates the expression of filaggrin, loricrin, and involucrin via signal transducer and activator of transcription 6 (STAT6) activation, impairing the epidermal terminal differentiation and barrier dysfunction [14,15,37,44,61,64,65]. IL-4/IL-13 signaling is likely to impair the cytoplasmic to nuclear translocation of OVOL1, which interferes with the AHR-OVOL1-filaggrin axis [59,61].…”
Section: Ahr and Epidermal Terminal Differentiationmentioning
confidence: 99%