Cutaneous phaeohyphomycosis caused by
            <i>Exserohilum rostratum</i>
            : a case with unusual presentation

Pan, Yun; Dai, Wei; Fang, Sheng

doi:10.1111/ced.14477

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…(Reproduced from reference Wang et al (2004) [original Figure 2 ]) (F) Infiltrating red plaques on both sides of the face and the upper lip; disfiguring verrucous plaques and ulcers on either side of the nasal ala. (Reproduced from reference Wang et al, (2004) [original Figure 1 ]) (G) (H) Nodules, papules, hemorrhagic vesicles, and pustules lesions on the bilateral forearm and trunk. (Reproduced from reference Pan et al (2021) [original Figure 1A, B ]) (I) Infiltrative swelling erythematous plaques on the face with purulent, smelly discharge. (Reproduced from reference Yan et al (2016) [original Figure 1A ]).…”

Section: Resultsmentioning

confidence: 99%

Phaeohyphomycosis in China

Zheng

Mei

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundDue to more attentions paid to melanized fungi over the past few decades and under the background of the global coronavirus disease 2019 pandemic (COVID-19) the fact that the virus itself and the immunosuppressive agents such as glucocorticoids can further increase the risk of infections of deep mycoses, the number of patients with phaeohyphomycosis (PHM) has a substantial increase. Their spectrum is broad and the early diagnosis and treatments are extremely sticky. This study aims to more comprehensively understand the clinical features of phaeohyphomycosis in China over 35 years and to establish a more applicable systematical classification and severity grades of lesions to guide treatments and prognosis.MethodsWe reviewed 174 cases of proven phaeohyphomycosis reported in Chinese and English language literature from 1987 to 2021 and we also made the accurate classification definitions and detailed information about the epidemiology, species of clinical dematiaceous fungi, minimum inhibitory concentration values, clinical features, treatments, and prognosis.ResultsThe mortality of cerebral, disseminated and pulmonary phaeohyphomycosis are 55%, 36%, and 25%. Nearly 19% of patients had poor quality of life caused by the complications such as disability, disfigurements, and blindness. The overall misdiagnosis rate of phaeohyphomycosis was 74%. Moderate to severe rashes are accounting for 82% of subcutaneous phaeohyphomycosis. The areas of the head and face are mostly affected accounting for 16% of severe rashes. Nearly 30% of invasive infections of phaeohyphomycosis are triggered by recurrent lesions. Voriconazole, itraconazole, amphotericin B deoxycholate (AmB-DOC), and terbinafine were most commonly used but diagnosis and treatments of phaeohyphomycosis remain challenging in reality.ConclusionsOur classifications are likely to be more practical and easier to popularize, and there are still also plenty of characteristics in these non-specific lesions. There’re no significant variations in cure rates, or death rates between three grades of lesions. But patients with severe rashes have longer courses and lower effective rates.

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Section: Resultsmentioning

confidence: 99%

Phaeohyphomycosis in China

Zheng

Mei

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Only three species of the group would fall into human pathogens: E. rostratum, E. longirostratum, and E. mcginnisii. 5,6 Except for the 2012 outbreak of meningitis, there are few reported cases of infection by ER. 6 In fact, there are only 11 diagnosed cases in immunocompromised children worldwide, being this one the second in Europe for ER in a child with B-ALL.…”

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confidence: 99%

Combination of debridation, vacuum system, and epidermal micrografting system for the treatment of an Exserohilum rostratum skin infection in a pediatric cancer patient

Martínez

Sanchís

Cortes

et al. 2021

Dermatologic Therapy

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Exserohilum rostratum (ER) is a dematiaceous, environmental and fastgrowing fungus causing invasive and cutaneous infections. Immunosuppression is the main risk factor for developing this infection. [1][2][3][4] A 6-year-old male patient was diagnosed with common B-cell acute lymphoblastic leukemia (B-ALL), after attending the emergency room with malaise and prolonged fever over the last week, along with severe pancytopenia. He was admitted for further diagnostic studies and given appropriate therapy (protocol SEHOP-PETHEMA-2013 1 ).Chemotherapy consisted of prednisone, vincristine, daunorubicin, PEG-asparaginase, and triple intrathecal chemotherapy. 4 Fourteen days after admission, he developed a necrotic eschar of 5 cm in diameter in the back of his right leg at the distal third. In suspi-

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Cutaneous phaeohyphomycosis caused by Exserohilum rostratum : a case with unusual presentation

Cited by 2 publications

References 5 publications

Phaeohyphomycosis in China

Phaeohyphomycosis in China

Combination of debridation, vacuum system, and epidermal micrografting system for the treatment of an Exserohilum rostratum skin infection in a pediatric cancer patient

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