Cutaneous plasmacytosis: a clinicopathologic study of 12 cases in <scp>T</scp>aiwan revealing heterogeneous underlying causes

Lu, Pei-Hsuan; Shih, Lih‐Yuann; Yang, Chih‐Hsun; Kuo, Tseng‐Tong

doi:10.1111/ijd.12694

Cited by 17 publications

(32 citation statements)

References 23 publications

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“…Possible IgG4-RD was diagnosed in 2 of the 9 patients. In a recent study, none of the patients fulfilled the criteria for IgG4-RD, even though 7 of the 9 patients had elevated serum IgG4 concentrations [8] .…”

Section: Laboratory Resultsmentioning

confidence: 94%

“…Because diagnostic procedures are still being established, underlying systemic involvement is often not excluded in these patients. All cases of cutaneous plasmacytosis may therefore represent cutaneous manifestations of an underlying benign form of systemic plasmacytosis [8] . On the other hand, patients with cutaneous plasmacytosis often have systemic manifestations of the disease, including anemia, fever, hepatomegaly, and superficial lymphadenopathy.…”

Section: Discussionmentioning

confidence: 99%

“…Cases have been reported among Chinese patients living in different geographic areas, including 3 Chinese immigrants in the USA [5,6] , 1 case in Singapore [7] , and several cases among Taiwanese patients [8,9] .…”

Section: Introductionmentioning

confidence: 99%

“…The cutaneous lesions are usually multiple round-to-oval, red-to-dark-brown macules, papules, and plaques, and are most often found on the trunk [1] , the face, the nape of the neck, and on the back, as well as in the axillae. The lesions rarely affect the limbs, and the palms and soles are also spared [4,7,8] . The lesions are not scaly, and no cases of crusts or erosions have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Cutaneous Plasmacytosis at Different Disease Stages

Hsiao

Wu²

2016

Dermatology

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Background/Aims: Cutaneous plasmacytosis is rare and still not well understood. A retrospective study was made of 9 Chinese patients with 1- to 15-year histories of biopsy-proven cutaneous plasmacytosis diagnosed between 2003 and 2015. Methods: Patient records and archival photographs helped establish the pattern and duration of skin lesions, and skin biopsy specimens provided additional data. Results: The mean age at diagnosis was 46.4 years. Two patients had lesions within 1 year of developing the disease, and 4 had lesions lasting longer than 5 years. One patient had lymphadenopathy of the neck that was later determined to be Castleman disease. Three patients had elevated IgG4 levels; only 2 had increased IgG4+ cells in skin tissues. Flexural accentuation was prominent. Four patients had elevated IgG levels, and 1, with an IgG level >5,000 mg/dL, developed systemic plasmacytosis (later confirmed as Castleman disease). The level of IgG4 subclass was related to disease duration, whereas IgG4+ plasma cells in tissues seemed irrelevant. Conclusion: Routine laboratory tests, especially measurement of IgG4 levels, may be useful for following patients with cutaneous plasmacytosis. Because of the retrospective nature of our study, we could only evaluate the results of a single IgG4 test for each patient, but the results pointed to cutaneous plasmacytosis in all 9 patients, who had different stages of the disease. Serial skin biopsies may also be helpful for gauging disease progress. Although IgG4-related disease was not established in any of these patients, long-term follow-up is warranted for all patients.

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Section: Laboratory Resultsmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization of Cutaneous Plasmacytosis at Different Disease Stages

Hsiao

Wu²

2016

Dermatology

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“…CMZBCL is a challenging differential diagnosis, as the lymphoplasmacytic or plasmacytic variants are also characterized by plasma cells within a dermal infiltrate. A few cases of otherwise typical CP have demonstrated evidence of monoclonality, suggesting that CP may represent a forme fruste of CMZBCL . Alternatively, reports of increased serum levels of interleukin‐6 suggest a relationship with multicentric Castleman disease .…”

Section: Discussionmentioning

confidence: 99%