Cutaneous plasmacytosis: Report of a case in a white man

López‐Estebaranz, José Luis; Rodríguez‐Peralto, José Luis; Romero, Pablo Luis Ortiz; Vanaclocha, F.; Diez, L. Iglesias

doi:10.1016/s0190-9622(94)70255-1

“…The clinical morphology of CSP is characterized by round or oval, red-brown to dark brown poorly circumscribed macules, papules and plaques [8,18,19]. Individual lesions can demonstrate a zone-like appearance with an elevated center and a flat border.…”

Section: Dermatological Findingsmentioning

confidence: 99%

“…Histopathologically, CSP must be differentiated from other dermatoses that are typically or occasionally characterized by plasma cell infiltrations. These include malignant monoclonal proliferations, such as marginal zone lymphoma, cutaneous plasmocytoma and leukemia cutis in plasma cell leukemia [17,19,20]. Further histopathological differential diagnoses with a polyclonal infiltration pattern are the B-cell pseudolymphomas and multicentric Castleman disease as well as syphilis and borreliosis.…”

Section: Differential Diagnosesmentioning

confidence: 99%

Cutaneous and systemic plasmocytosis

Wagner

¹

,

Rose²,

Klapper

³

et al. 2013

J Deutsche Derma Gesell

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SummaryCutaneous and systemic plasmacytosis is a rare disorder observed mainly in Japanese that features an infiltration of mature plasma cells in various organ systems. In addition to the skin, lymph nodes and bone marrow are regularly affected. Laboratory tests show a polyclonal hypergammaglobulinemia. The cutaneous morphology is characterized by red to dark brown macules, papules and plaques a few centimeters in diameter, usually distributed symmetrically on the face, neck and back. Etiology and pathogenesis are not known. It is speculated that a reactive dysfunction of plasma cells may be triggered by various stimuli, such as interleukin 6. Treatment of cutaneous and systemic plasmacytosis is difficult. A standardized treatment concept does not yet exist. Topical corticosteroids and calcineurin inhibitors are mainly used.

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“…Die klinische Morphologie der KSP ist geprägt durch 1−4 cm durchmessende, runde oder längsoval ausgerichtete, unscharf begrenzte, rotbraun bis dunkelbraun tingierte Maculae, Papeln und Plaques [8,18,19]. Einzelne Läsionen können einen zonalen Aufbau zeigen mit aufgeworfenem Zentrum und fl acher Randzone.…”

Section: Dermatologische Befundeunclassified

“…Histopathologisch ist die KSP von allen anderen Dermatosen abzugrenzen, die typischerweise oder gelegentlich durch Plasmazellinfi ltrationen gekennzeichnet sind. Hierzu zählen maligne monoklonale Proliferationen wie das Marginalzonenlymphom, das kutane Plasmozytom und die Leucaemia cutis bei Plasmazellleukämie [17,19,20]. Weitere histopathologische Differenzialdiagnosen mit einem polyklonalen Infi ltrationsmuster sind die B-Zell-Pseudolymphome und der multizentrische Morbus Castleman sowie bei Infektionen die kutanen Manifestationen der Syphilis und der Borreliose.…”

Section: Differenzialdiagnosenunclassified

“…Weitere histopathologische Differenzialdiagnosen mit einem polyklonalen Infi ltrationsmuster sind die B-Zell-Pseudolymphome und der multizentrische Morbus Castleman sowie bei Infektionen die kutanen Manifestationen der Syphilis und der Borreliose. Auch Kollagenosen, insbesondere die Morphea, seltener der Lupus erythematodes, sind bisweilen zu berücksichtigen [5,10,11,19,20].…”

Section: Differenzialdiagnosenunclassified

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Kutane und systemische Plasmozytose

Wagner

¹

,

Rosé²,

Klapper

³

et al. 2013

J Deutsche Derma Gesell

7

0

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SummaryCutaneous and systemic plasmacytosis is a rare disorder observed mainly in Japanese that features an infiltration of mature plasma cells in various organ systems. In addition to the skin, lymph nodes and bone marrow are regularly affected. Laboratory tests show a polyclonal hypergammaglobulinemia. The cutaneous morphology is characterized by red to dark brown macules, papules and plaques a few centimeters in diameter, usually distributed symmetrically on the face, neck and back. Etiology and pathogenesis are not known. It is speculated that a reactive dysfunction of plasma cells may be triggered by various stimuli, such as interleukin 6. Treatment of cutaneous and systemic plasmacytosis is difficult. A standardized treatment concept does not yet exist. Topical corticosteroids and calcineurin inhibitors are mainly used.

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