Cutaneous polyarteritis nodosa in a patient with Crohn’s disease

Komatsuda, Atsushi; Kinoshita, Koji; Togashi, Masaru; Maki, Nobuki; Masai, Rie; Niitsu, H; Ohtani, Setsuya; Sato, Masato; Sawada, Kenichi; Wakui, Hideki

doi:10.1007/s10165-008-0110-8

Cited by 11 publications

(7 citation statements)

References 9 publications

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“…In addition, comorbidities of cutaneous arteritis include inflammatory bowel disease, which was previously observed in 10% of 79 patients with cutaneous arteritis. 5 Only several cases of cutaneous arteritis associated with inflammatory bowel disease have been reported to date; however, in comparison with Crohn's disease, 16 cases of ulcerative colitis are rarely reported. 17 In the current study, three patients developed ulceration among 10 patients complaining of numbness, and all of them were treated with oral prednisolone.…”

Section: Ta B L Ementioning

confidence: 70%

Cutaneous arteritis: Clinicopathological study of 21 cases

Hiraiwa

Chen²,

Yamamoto

2023

J Cutaneous Imm & Allergy

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ObjectivesWe conducted this study to clarify the progress of cutaneous arteritis.MethodsWe examined 21 cases of cutaneous arteritis that were diagnosed at our hospital between 2005 and 2020. The male‐to‐female ratio was 1:6 with a mean age of 52.2 years.ResultsThe lower legs were involved in all cases, and the upper extremities or trunk was also involved in some cases. Cutaneous manifestations presented as indurated erythema (n = 15), subcutaneous induration (11), edema (7), livedo (6), and ulcer (3). In addition, extracutaneous conditions including numbness (10), arthritis (8), fever (2), and myalgia (1) were observed. Laboratory tests showed an increase of inflammatory markers in most cases (14). Histopathological features showed necrotizing vasculitis of small‐sized arteries at the dermo‐subcutaneous junction, and the inflammatory stages of arteritis were histopathologically divided into acute stage (5), subacute stage (5), reparative stage (7), and healed stage (1). The therapies administered were oral prednisolone (11), antiplatelet drug (14), warfarin (1), non‐steroidal anti‐inflammatory drugs (6), biological drug (1), and other drugs (14). There were no cases showing progression to systemic polyarteritis nodosa during follow‐up period. All three patients with ulceration complained of numbness, and one was revealed to have mononeuropathy multiplex. They were treated with low‐dose oral prednisolone. Three ulceration cases were histopathologically classified into the acute and subacute stages.ConclusionsIn conclusion, all 21 patients followed a chronic course with recurrent skin lesions without systemic complications. Cases with ulceration seem to reveal neurological symptoms and need systemic steroid treatment.

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Section: Ta B L Ementioning

confidence: 70%

Cutaneous arteritis: Clinicopathological study of 21 cases

Hiraiwa

Chen²,

Yamamoto

2023

J Cutaneous Imm & Allergy

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“…Along with the presented case, we find only a handful of cases reporting the co-occurrence of PAN with CD [10][11][12][13][14][15][16][17][18][19][20] (Table 1). In some of them, PAN was concluded to be a rare cutaneous manifestation of IBD, specifically CD, that may precede, coincide, or follow gastrointestinal symptoms.…”

mentioning

confidence: 65%

“…Noteworthy, because cPAN involves vessels within the deep dermis, clinicians should consider excision biopsy over superficial biopsy. 12 Komatsuda et al presents a 19-year-old female with a 4-year history of CD that developed high fever, polyarthralgia, and painful subcutaneous nodules of the legs. 12 Biopsy showed panarteritis with fibrinoid necrosis, lymphocyte infiltration of dermal arteries and septal panniculitis.…”

mentioning

confidence: 99%

Coinciding Crohn's disease and polyarteritis nodosa: A sign of medically refractory disease?

Shweikeh,

Tran,

Lane

et al. 2024

Int J of Rheum Dis

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“…It shows vasculitis with panniculitis and necrosis of vessels with fibrin deposition. Previous studies 5 have reported polyarteritis nodosa as a cutaneous manifestation of Crohn's disease. Of the 15 cases reported, skin lesions preceding Crohn's disease developed in 3 6 7 8 .…”

Section: Discussionmentioning

confidence: 94%

Crohn's Disease with Cutaneous Polyarteritis Nodosa in a Child: A Case Report

et al. 2021

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A 10-year-old boy presented with a 1-day history of multiple painful erythematous skin lesions on his upper and lower extremities. He was admitted to the Department of Pediatrics with persistent right lower abdominal pain and diarrhea. Punch biopsy of a skin lesion on his lower leg showed necrotizing granulomatous vasculitis with septal panniculitis consistent with polyarteritis nodosa, and our differential diagnosis included cutaneous manifestations of Croh's disease. Abdominal ultrasonography revealed distended colonic loops suggestive of inflammatory bowel disease. Upper and lower gastrointestinal endoscopy revealed lesions involving the duodenum, cecum, colon, and rectum. He developed multiple perianal fistulas during hospitalization. Additional laboratory tests revealed positive results for anti-saccharomyces cerevisiae and antinuclear antibodies. Based on his clinical presentation and laboratory findings, he was diagnosed with Crohn's disease associated with cutaneous polyarteritis nodosa. We report a rare case of a child who presented with cutaneous polyarteritis nodosa as an extraintestinal manifestation of Crohn's disease.

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Cutaneous polyarteritis nodosa in a patient with Crohn’s disease

Cited by 11 publications

References 9 publications

Cutaneous arteritis: Clinicopathological study of 21 cases

Cutaneous arteritis: Clinicopathological study of 21 cases

Coinciding Crohn's disease and polyarteritis nodosa: A sign of medically refractory disease?

Crohn's Disease with Cutaneous Polyarteritis Nodosa in a Child: A Case Report

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