Cutaneous Presentation of Mantle Cell Lymphoma

Canpolat, Filiz; Tas, Eylem; Sönmez, Aynur; Oktay, Murat; Eskioğlu, Fatma; Alper, Murat

doi:10.2340/00015555-0886

Cited by 23 publications

(20 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The blastoid variant is found in 10-30% of those diagnosed with MCL and has a shorter median survival time than classical type (15 vs. 45 months) [5,8,9]. The skin involvement, even if rare, has been more frequently reported in the blastoid variant of MCL [2]. MCL appears as monomorphic, small-to-medium-sized lymphoid cells with irregular nuclear contours on microscopy [10], while the blastoid variant exhibits lymphoblast-like cells with dispersed chromatin and high mitotic rate (approximately 20 -30/high power field (HPF)) [5].…”

Section: Discussionmentioning

confidence: 99%

“…This results in overexpression of cyclin D1, which serves as a positive signal for transition to the S phase [2]. Similar to translocation (11:14), cyclin D1 is characteristic to MCL and is expressed in more than 60-70% of cases of MCL but also can be positive in 4% of B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) [11].…”

Section: Discussionmentioning

confidence: 99%

“…It originates from the proliferation of mature B cells in the mantle zone of lymphoid follicles. Hallmarks of diagnosis that have been historically well known are translocation (11:14) and cyclin D1, the former causing overexpression of the latter [1,2]. Over the time, CD5 and recently SOX11 have also become an essential part of the diagnosis [3,4].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mantle Cell Lymphoma Relapsing as Disease of Skin, Orbit and CNS: An Extremely Rare Presentation and a Review of Literature

Shaikh¹,

Jani²,

Shah³

et al. 2018

J Hematol

View full text Add to dashboard Cite

Mantle cell lymphoma (MCL) is a form of non-Hodgkin's lymphoma originating from mature B cells. The hallmark gene translocation (11:14) results in overexpression of cyclin D1. Affected extranodal sites include bone marrow and gastrointestinal tract, but skin, orbit or CNS are rarely involved. Twenty-four cases have reported involvement of skin by MCL, while orbital MCL is equally rare. Our case is the first to report relapsed MCL with involvement of the skin and orbit simultaneously without disease in the lymphatic system or the bone marrow. A 53-year-old female with stage IV MCL initially presented with pancytopenia, adenopathy and splenomegaly. She achieved complete remission after six cycles of rituximab and bendamustine. Within 4 weeks of treatment, she developed diplopia and a rash of the left breast. Skin biopsy showed lymphoma infiltrates with B-cell markers for MCL. MRI of the orbits and brain suggested orbital lymphoma. CSF cytology further confirmed MCL cells. At time of relapse, she continued to be in hematologic remission. She initiated intrathecal cytarabine and methotrexate along with ibrutinib. R-CHOP was then added to the regimen. Within 2 weeks of starting treatment, her skin disease resolved and she had improvement in vision. MCL commonly presents as a disseminated disease, resulting in high mortality. Involvement of the skin or orbit has been sparingly reported and always suggests aggressive disease. It thus poses a challenge to diagnose and treat the condition as evidenced by resolution of adenopathy and bone marrow disease. Due to the overall poor prognosis of MCL and its unique presentations, as demonstrated by our case, early detection and prompt treatment are crucial to survival.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mantle Cell Lymphoma Relapsing as Disease of Skin, Orbit and CNS: An Extremely Rare Presentation and a Review of Literature

Shaikh¹,

Jani²,

Shah³

et al. 2018

J Hematol

View full text Add to dashboard Cite

show abstract

“…One of few available case studies found that skin lesions were nodular in 34%, macular or maculopapular also in 34%, tumoural or infiltrated plaques in 21% and subcutaneous nodules in 11% of cases [5,6].…”

Section: Skin Manifestationsmentioning

confidence: 99%

“…W jednej z niewielu analiz przypadków stwierdzono, że zmiany mają charakter guzkowaty w 34%, plamisty lub plamisto-grudkowy w 34%, charakter guzowaty lub postać nacieczonych ognisk w 21% oraz guzów podskórnych w 11% [5,6]. though much less pronounced, were also present in the areas of the supraorbital ridges.…”

Section: Manifestacje Skórneunclassified

Skin manifestation of mantle cell lymphoma – case report and literature review

Markiewicz¹,

Zdanowska²,

Owczarczyk‐Saczonek³

et al. 2017

View full text Add to dashboard Cite

Mantle cell lymphoma is a rare neoplastic disease of the lymphatic system derived from mature B lymphocytes. It very commonly affects extranodal sites including the bone marrow, gastrointestinal tract and Waldeyer's ring, but skin involvement is seen extremely rarely. The disease often has a recurrent and aggressive course. The diagnosis is usually established late, at an advanced stage of the disease. We present the case of a patient with skin lesions developing as the first manifestation of a haematological disease. After the appearance of symptoms the patient had several medical consultations before the final diagnosis was made at a dermatology outpatient clinic. Only few cases of cutaneous manifestations of mantle cell lymphoma have been described. streszczenie Chłoniak z komórek płaszcza jest rzadko występującą chorobą nowotworową układu chłonnego wywodzącą się z dojrzałych limfocytów B. Często zajmuje lokalizacje pozawęzłowe, zazwyczaj szpik kostny, układ pokarmowy, pierścień Waldeyera, ale wyjątkowo rzadko skórę. Choroba zwykle charakteryzuje się nawrotowym, agresywnym przebiegiem. Najczęściej rozpoznawana jest późno, w zaawansowanym stadium. Przedstawiamy przypadek pacjenta, u którego zmiany skórne były pierwszym objawem choroby hematologicznej. Pacjent z powodu objawów odbył kilka konsultacji lekarskich, zanim postawiono ostateczną diagnozę podczas wizyty w poradni dermatologicznej. Dotychczas opisano niewiele przypadków skórnej manifestacji chłoniaka z komórek płaszcza.

show abstract

Primary Cutaneous B-cell Lymphomas: FL, MCL, Differential Diagnosis

LeBlanc

2020

Molecular and Translational Medicine

View full text Add to dashboard Cite

Cutaneous Presentation of Mantle Cell Lymphoma

Cited by 23 publications

References 12 publications

Mantle Cell Lymphoma Relapsing as Disease of Skin, Orbit and CNS: An Extremely Rare Presentation and a Review of Literature

Mantle Cell Lymphoma Relapsing as Disease of Skin, Orbit and CNS: An Extremely Rare Presentation and a Review of Literature

Skin manifestation of mantle cell lymphoma – case report and literature review

Primary Cutaneous B-cell Lymphomas: FL, MCL, Differential Diagnosis

Contact Info

Product

Resources

About