Cutaneous pseudolymphoma caused by tumor necrosis factor‐α inhibitors was not induced by ustekinumab

Infliximab‐related atypical lymphoid hyperplasia mimicking primary cutaneous lymphoma of the ear

“…3,4 Lesions involute after drug discontinuation but in some cases relapses have occurred after introducing another anti-TNFα drug. 4,5 In one case, it was not subsequently induced by ustekinumab, suggesting a class effect. 5 Histologically, they usually show a superficial band-like infiltrate, with variable degrees of spongiosis and epidermotropism, sometimes mimicking mycosis fungoides, but nodular or diffuse lymphoid infiltrates imitating B-cell lymphomas have also been reported.…”

“…4,5 In one case, it was not subsequently induced by ustekinumab, suggesting a class effect. 5 Histologically, they usually show a superficial band-like infiltrate, with variable degrees of spongiosis and epidermotropism, sometimes mimicking mycosis fungoides, but nodular or diffuse lymphoid infiltrates imitating B-cell lymphomas have also been reported. 6 Differential diagnosis with primary cutaneous lymphoma may be challenging and our case closely simulated a primary cutaneous acral CD8+ T-cell lymphoma.…”

Not Jessner‐Kanof But Cutaneous Lymphoid Hyperplasia Induced by Etanercept: Comment on the Clinical Images Report by Abbad et al

“…In addition to histologic assessment, immunophenotyping and molecular studies may be required in order to exclude malignancies. Finally, other case reports of lymphocytic eruption induced by anti–tumor necrosis factor inhibitors have been reported under the vocable of “cutaneous pseudolymphoma” , which is more accurate than lymphocytic infiltration of Jessner‐Kanof, but cutaneous lymphoid hyperplasia should be preferred.…”