Cutaneous reactions due to Pfizer's BNT162b2 mRNA and Moderna's mRNA‐1273 vaccines

Abstract

Dear Editor,The clinical trials for the Moderna and Pfizer COVID-19 vaccines reported local injection site cutaneous reactions 1,2 ; however, varied cutaneous reactions have been noted including delayed large local cutaneous reaction called 'COVID arm' and rashes characterized by their dermatologic morphological equivalents including urticarial, morbilliform, pernio/chilblains-like and pityriasis rosea-like reactions. [3][4][5]

Cutaneous Reactions after COVID-19 Vaccines: Analysis of the Clinical and Histopathological Spectrum—Case Series and Review of the Literature

“…Whereas "COVID arm" usually resolves within 1 or 2 weeks, generalized ADRs lasted in many patients in our cohort for more than 28 days and in some patients even longer than 6 months. This duration is longer than the data reported by other groups, which observed regression of ADRs in most patients within 14 days [5,6,28,29]. In V-REPP, however, longer duration times of up to 49 days and rarely up to 90 days were reported.…”

“…Our cohort differs in two epidemiologic aspects from other studies. In our cohort, the gender distribution is equal, whereas other studies reported a higher number of ADRs in women [6,9,17,23,26,28]. Second, the vast majority of our patients (75%) had received the mRNA-1273 vaccine, as in Switzerland far more people in general were vaccinated with mRNA-1273 [4].…”

Cutaneous Reactions after COVID-19 Vaccines – Analysis of the Clinical and Histological Spectrum – Case Series and Review of the Literature

“…Whereas 'COVID arm' usually resolves within 1 or 2 weeks, generalized ADRs lasted in our cohort in many patients for more than 28 days and in some patients even longer than 6 months. This duration is longer than the data reported by other groups which observed regression of ADRs in most patients within 14 days [5,6,28,29]. In V-REPP, however, longer duration times of up to 49 days and rarely up to 90 days were reported.…”