Cutaneous reactions to vitamin K1 injections

Cutaneous allergic reaction to intramuscular vitamin K1

“…It was previously thought that liver disease predisposed patients to adverse cutaneous reactions to vitamin K1, 2 but there have been several reports of reaction occurring in the absence of liver disease 16 , 18 –21 . The association can be explained by the observation that patients with liver disease are more likely to have hypoprothrombinaemia and thus are more likely to be given vitamin K1.…”

Adverse skin reactions to vitamin K1: report of 2 cases

“…However, since then, patients with no signs of liver disease have been described: therefore, the high prevalence of adverse reactions in patients with hepatic disease probably depends on the large number of hepatopathic patients needing treatment with vitamin K (2). To the best of our knowledge, no cases have been described in which orally administered vitamin K resulted in adverse reactions: only parenteral oil-soluble vitamin K seems to be able to react (1)(2)(3)(4)(5)(6)(7)(8)(9)(10).…”

Phytonadione Therapy in a Multiple‐Drug Overdose Involving Warfarin

“…The more common one is a pruritic, erythematous, eczematoid, indurated plaque measuring 6-20 cm around the site of injection. [39][40][41][42][43][44][45][46][47][48][49][50][51][52] The acute reaction may resolve in 2-4 weeks with treatment with high-potency corticosteroids (e.g., fluocinonide, betamethasone dipropionate). The second type appears as a scleroderma or morphea-like reaction.…”

“…39 Dose does not appear to bear a relationship to the onset of these reactions. Liver disease was associated with most reports of vitamin K cutaneous hypersensitivity, 39,41 but the pathophysiology is unclear.…”