Cutaneous Rosai‐Dorfman Disease: Presenting as Massive Bilateral Eyelid Swelling

Jat, Kana Ram; Panigrahi, Inusha; Srinivasan, Radhika; Singh, Usha; Vasishta, R. K.; Sharma, Nitisha; Duggal, Rajan; Marwaha, Ram Kumar

doi:10.1111/j.1525-1470.2009.01011.x

Cited by 15 publications

(9 citation statements)

References 4 publications

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“…[ 4 6 ] Eyelid involvement in Rosai–Dorfman disease is mostly by contiguous spread from adjacent tissues such as orbit or paranasal sinuses. [ 7 8 9 ] A single case with eyelid involvement with isolated cutaneous patches over the chest and legs was reported by Prabhakaran et al ., in their series of five cases presenting in the orbit and adnexal regions. [ 10 ] In a series of seven patients by Vemuganti et al ., two cases presented with eyelid involvement predominantly, although there was involvement of adjacent structures too.…”

Section: Discussionmentioning

confidence: 99%

Isolated unilateral eyelid Rosai–Dorfman disease

et al. 2018

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Isolated eyelid Rosai–Dorfman disease without orbital disease or systemic involvement is very rare and needs a high degree of suspicion. In this report, we describe a 16-year-old boy who presented with isolated eyelid Rosai–Dorfman disease involving the right upper eyelid. The lesion was treated by surgical debulking followed by intralesional steroid injection for the residual lesion. The child did well with no evidence of recurrence of the lesion at 1-year follow-up.

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Section: Discussionmentioning

confidence: 99%

Isolated unilateral eyelid Rosai–Dorfman disease

et al. 2018

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“…Yet, there are a few patients reporting refractory or persistent disease. [ 20 ] There are numerous treatment modalities for cutaneous RDD, including surgical excision, corticosteroids, thalidomide, cryosurgery, radiotherapy, dapsone, isotretinoin, interferon α, acitretin, and pulsed dye laser; all of these agents have shown varying rates of success. [ 21 22 23 24 25 ] In a clinical and histopathologic study of 25 patients with cutaneous RDD, clinical follow-up in 22 patients indicated that surgical excision was the exclusive effective treatment.…”

Section: Discussionmentioning

confidence: 99%

Purely cutaneous rosai-dorfman disease with immunohistochemistry

et al. 2013

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Background:The cutaneous form of Rosai-Dorfman disease (RDD) is a rare entity that manifests solely with skin papules or nodules and does not present with the usual myriad of symptoms of classical RDD.Aims:To analyze the most recent publications regarding cutaneous RDD to point out updated, relevant aspects regarding future directions for clinical recognition and management. To identify histopathologic and immunohistochemical findings in skin lesions that permit diagnosis.Materials and Methods:We present a case of a gentleman with a history of multiple lipomas with a new solitary nodule on physical exam; microscopic examination shows the typical findings of RDD with the associated diagnostic immunohistochemical profile, as well as the expected finding of histiocytes engulfing other intact inflammatory cells.Results:Our patient was managed with surgical excision of the entire lesion, one of the several available treatment options. Long-term follow-up 2 years later did not reveal any complications, recurrences, or new lesions.Conclusion:The diagnosis of cutaneous RDD is differentiated from other histiocytic conditions by the combination of clinical findings accompanied by histopathologic and immunohistochemical confirmation.

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“…Different types of skin lesions have been described such as infiltrated erythematous/brownish/yellowish papules, nodules, subcutaneous masses, ulcerated nodules, and rosacea‐like lesions affecting most commonly the face but also other parts of the body . Ocular or periorbital lesions including periorbital masses and eyelid lesions have also been reported . Yellowish papules on the eyelids, periorbital area, or rim of the eye concomitant with “xanthelasma‐like” appearance on other parts of the face and extention to the neck, bilateral eyelid swelling, and yellow xanthomatous eyelid masses were some of the reported examples for eyelid lesions.…”

Section: Non‐langerhans Cell Histiocytosesmentioning

confidence: 99%

“…[51][52][53] Ocular or periorbital lesions including periorbital masses and eyelid lesions have also been reported. [53][54][55] Yellowish papules on the eyelids, periorbital area, or rim of the eye concomitant with "xanthelasma-like" appearance on other parts of the face and extention to the neck, 52 bilateral eyelid swelling, 54 and yellow xanthomatous eyelid masses 55 were some of the reported examples for eyelid lesions. Ocular lesions may cause proptosis, blepharoptosis, uveitis, impaired extraocular motility, decreased vision, and diplopia.…”

Section: Reticulohistiocytosismentioning

confidence: 99%

The clinical spectrum of xanthomatous lesions of the eyelids

et al. 2017

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Yellowish papules, nodules, or plaques, namely "xanthomatous" lesions, may be seen on the eyelids in the course of various disorders. The prototype is "xanthelasma palpebrarum" (XP) that is localized only to the eyelids and may be associated with hyperlipidemia. On the other hand, different types of normolipemic disorders may also cause xanthomatous eyelid lesions. Among these, Langerhans cell histiocytosis, diffuse normolipemic xanthoma, and non-Langerhans cell histiocytoses (papular xanthoma, juvenile xanthogranuloma, xanthoma disseminatum, adult-onset xanthogranuloma, adult-onset asthma and periocular xanthogranuloma, necrobiotic xanthogranuloma, Erdheim-Chester disease, Rosai-Dorfman disease, and reticulohistiocytosis) can be listed. The eyelid findings of this heterogeneous group of disorders are challenging to differentiate from each other due to common clinical aspects that may even sometimes mimic XP. Nodularity, induration, ulceration, diffuse eyelid involvement, and extension from eyelids to the neighboring skin may represent the clinical features of xanthomatous lesions other than XP. It is necessary to obtain a thorough history and exclude XP and then perform detailed dermatological and systemic examination, biopsy for histopathologic confirmation, and appropriate specific imaging screens. As some of the conditions may be associated with other systemic disorders, especially malignancies, the differentiation of xanthomatous eyelid lesions has a critical importance, and clinical signs can be guiding.

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Cutaneous Rosai‐Dorfman Disease: Presenting as Massive Bilateral Eyelid Swelling

Cited by 15 publications

References 4 publications

Isolated unilateral eyelid Rosai–Dorfman disease

Isolated unilateral eyelid Rosai–Dorfman disease

Purely cutaneous rosai-dorfman disease with immunohistochemistry

The clinical spectrum of xanthomatous lesions of the eyelids

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