Cutaneous Rosai-Dorfman disease

A case of cutaneous Rosai–Dorfman

“…Numerous treatments have been described including corticosteroids, thalidomide, dapsone, retinoids, methotrexate, radiotherapy, laser, or surgical excision. 2 In conclusion, we have described a rare dermatological entity that should be considered in the differential diagnosis of cutaneous granulomatous diseases. Given the wide variability of its clinical presentation, a histological study is essential for reaching the diagnosis.…”

“…The clinical presentation is variable (papules, nodules, and plaques) and can be located in any anatomical region. Skin lesions are generally asymptomatic, 2 and a few characteristic dermatoscopic features are described in the literature: “sign of the setting sun” 3 and cottony structures on an erythematous background 4 . The main histological finding is a dense infiltrate of histiocytes with emperipolesis that is typically positive for S‐100, negative for CD1a and Langerin, and with variable positivity for CD68 5 .…”

“…The prognosis is generally favorable, although some cases are associated with uveitis as well as autoimmune diseases. Numerous treatments have been described including corticosteroids, thalidomide, dapsone, retinoids, methotrexate, radiotherapy, laser, or surgical excision 2 …”