Cutaneous sarcoidosis: clinicopathologic study of 76 patients from <scp>L</scp>ebanon

Ishak, Rim; Kurban, Mazen; Kibbi, Abdul‐Ghani; Abbas, Ossama

doi:10.1111/ijd.12248

Cited by 27 publications

(30 citation statements)

References 43 publications

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“…Systemic involvement has been reported to be present in 30 to 85% of patients with cutaneous sarcoidosis . Most patients in this series showed systemic involvement (82.5%), with skin lesions present at the onset of the disease in the majority of them (80%).…”

Section: Discussionmentioning

confidence: 56%

The natural history of cutaneous sarcoidosis. Clinical spectrum and histological analysis of 40 cases

García-Colmenero¹,

Sánchez‐Schmidt²,

Barranco³

2018

Int J Dermatology

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Background Cutaneous lesions of sarcoidosis can allow physicians to establish the diagnosis of a systemic disease, but the need of monitoring patients presenting skin limited sarcoidosis in order to detect further extracutaneous involvement has rarely been evaluated. Objectives To review clinical and histological features of patients with cutaneous sarcoidosis and the risk of progression to systemic disease. To characterize the phenotype of patients with isolated cutaneous sarcoidosis and to assess the temporal relationship between cutaneous and systemic disease. Methods Retrospective review of a series of patients with cutaneous sarcoidosis. Clinical, histopathological, and evolutive features were reviewed. Results Forty patients were included in the study. Systemic disease was present in 82.5% of patients. Previous or concurrent cutaneous involvement occurred in 81.8% of them. Seven out of 14 patients with cutaneous lesions evolved to a systemic sarcoidosis in a mean time of 6 years, with a range between 4 and 9 years. No clinical or histological differences were found between patients with systemic sarcoidosis and those who showed persistent isolated cutaneous lesions. Conclusions Sarcoidosis may be manifested as an isolated cutaneous disorder. No clinical or histopathological features seem to be helpful to discriminate cases of a persistent isolated cutaneous disease from those that will develop systemic involvement. Since the development of systemic involvement in cases of isolated cutaneous sarcoidosis can occur many years afterward, careful monitoring seems advisable, and a long follow‐up is recommended.

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Section: Discussionmentioning

confidence: 56%

The natural history of cutaneous sarcoidosis. Clinical spectrum and histological analysis of 40 cases

García-Colmenero¹,

Sánchez‐Schmidt²,

Barranco³

2018

Int J Dermatology

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“…2,8,24,25 Compared with macules/papules, plaque sarcoidosis is less often associated with acute presentation of disease, does not occur in conjunction with erythema nodosum as frequently, and often predicts a more chronic course with a higher likelihood of recurrence. 2,8,24 In addition, systemic symptoms also seem to be more chronic, lasting longer than 2 years in most cases, and individuals can have persistent symptoms, including bilateral hilar lymphadenopathy, splenomegaly, pulmonary fibrosis, and uveitis, although these associations are based on small studies (Fig. 3).…”

Section: Common Morphologiesmentioning

confidence: 99%

“…121 Biopsies can have variable features, including dense lymphocytes, neutrophils, perineural invasion, caseation, and vasculitis. 8,118,119 Polarization of specimens for foreign material is important, but the presence of foreign material does not exclude the diagnosis of sarcoidosis (Fig. 16).…”

Section: Diagnosis and Work-upmentioning

confidence: 99%

“…The histopathologic differential diagnosis includes other granulomatous diseases, including granuloma annulare; necrobiosis lipoidica; foreign body reactions to tattoos; siliconosis; cutaneous Crohn disease; necrobiotic xanthogranuloma; and infections, specifically mycobacterial infections, including tuberculosis, leprosy, and atypical mycobacterial infections (see Box 1; Table 3). 8 TREATMENT Therapeutic decisions for sarcoidosis should be dictated by the organ most severely affected or that has the potential to lead to the most serious disease. Medications for systemic organ involvement often control cutaneous disease; at other times, the skin disease fails to respond and needs targeted therapy.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8] Cutaneous sarcoidosis may be the presenting sign of systemic disease and a high clinical index of suspicion is critical because there can be protean manifestations. 9,10 Sarcoidosis may affect patients of all races and at any age, although the clinical presentation may vary by ethnic background.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cutaneous Sarcoidosis

Wanat

Rosenbach

2015

Clinics in Chest Medicine

109

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The skin is the second most common organ affected in sarcoidosis, which can affect patients of all ages and races, with African American women having the highest rates of sarcoidosis in the United States. The cutaneous manifestations are protean and can reflect involvement of sarcoidal granulomas within the lesion or represent reactive non-specific inflammation, as seen with erythema nodosum. Systemic work-up is necessary in any patient with cutaneous involvement of sarcoidal granulomas, and treatment depends on other organ involvement and severity of clinical disease. Skin-directed therapies are first line for mild disease, and immunomodulators or immunosuppressants may be necessary.

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Sarcoidosis

Marcoval,

Mañá

2024

Rook's Textbook of Dermatology

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Sarcoidosis is an antigen‐mediated disease of unknown aetiology characterised by the presence of non‐caseating epithelioid cell granulomas in multiple organs. It involves mainly the lungs, mediastinal and peripheral lymph nodes, eyes and skin. Less frequent but usually severe manifestations can occur in the liver, spleen, central nervous system, heart, upper respiratory tract and bones. Cutaneous lesions of sarcoidosis may be specific, showing histopathologically sarcoid granulomas, or non‐specific, mainly erythema nodosum. Cutaneous lesions are frequently the presentation of the disease and skin biopsy enables early diagnosis. Moreover, some types of lesions have prognostic significance and may help to predict the outcome of the systemic disease.

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Cutaneous sarcoidosis: clinicopathologic study of 76 patients from Lebanon

Cited by 27 publications

References 43 publications

The natural history of cutaneous sarcoidosis. Clinical spectrum and histological analysis of 40 cases

The natural history of cutaneous sarcoidosis. Clinical spectrum and histological analysis of 40 cases

Cutaneous Sarcoidosis

Sarcoidosis

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