Cutaneous Sarcomas and Soft Tissue Proliferations

Jassim, Omar; Pfeifer, John D.

doi:10.1007/978-1-60761-171-4_8

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2013

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Cited by 2 publications

(2 citation statements)

References 327 publications

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“…Heinz Kutzner 1 , Luis Requena 2 , Gabriele Palmedo 1 , Thomas Mentzel 1 (1) Dermatopathologie Friedrichshafen, Friedrichshafen (2) Fundacion Jimenez Diaz, Madrid, Spanien Einleitung Die überwiegende Mehrzahl der mesenchymalen Tumoren ist gutartig. Maligne mesenchymale Tumoren, Sarkome, repräsentieren mit mehr als 70 Entitäten weniger als 1 % aller bösartigen Tumorerkrankungen und zählen damit zu den seltenen Tumoren [1,2]. Primäre kutane Sarkome machen 14 % aller Sarkome aus [3].…”

Section: Molekularpathologische Diagnostik Von Mesenchymalen Tumoren unclassified

Molekularpathologische Diagnostik von mesenchymalen Tumoren der Haut

Kutzner

Requena

Palmedo

et al. 2013

J Deutsche Derma Gesell

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Section: Molekularpathologische Diagnostik Von Mesenchymalen Tumoren unclassified

Molekularpathologische Diagnostik von mesenchymalen Tumoren der Haut

Kutzner

Requena

Palmedo

et al. 2013

J Deutsche Derma Gesell

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“…Although comprising more than 70 entities, malignant mesenchymal tumors, sarcomas, represent less than 1 % of all malignant tumors and may thus be considered rare [ 1,2 ] . Primary cutaneous sarcomas account for 14 % of all sarcomas [ 3 ] .…”

Section: Introductionmentioning

confidence: 99%

Molecular pathology diagnostics in cutaneous mesenchymal tumors

Kutzner

Requena

Palmedo

et al. 2013

J Deutsche Derma Gesell

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Histopathological diagnosis of mesenchymal tumors of the skin is based on a combination of conventional histological and immunohistochemical staining techniques with reliable cytogenetic and molecular genetic methods. Many sarcomas carry translocation-induced gene signatures (fusion genes) or characteristic gene amplifications and deletions which can be detected in formalin-fixed paraffin-embedded routine material. Fluorescence-in-situ hybridization (FISH), reverse transcriptase polymerase chain reaction (RT-PCR), and DNA sequencing (Sanger sequencing) are the preferred cytogenetic and molecular genetic techniques in a diagnostic routine setting and are widely used in conjunction with immunohistochemical phenotyping of tumor tissue. The combined immunohistochemical and molecular genetic algorithm of sarcoma diagnosis is shown in the context of dermatofibrosarcoma protuberans, malignant vascular tumors, epithelioid sarcoma, and clear cell sarcoma.

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Cutaneous Sarcomas and Soft Tissue Proliferations

Cited by 2 publications

References 327 publications

Molekularpathologische Diagnostik von mesenchymalen Tumoren der Haut

Molekularpathologische Diagnostik von mesenchymalen Tumoren der Haut

Molecular pathology diagnostics in cutaneous mesenchymal tumors

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