Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics

Tziotzios, Christos; Profyris, Christos; Sterling, Jane

doi:10.1016/j.jaad.2011.08.035

Cited by 159 publications

(130 citation statements)

References 98 publications

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“…However, the clinical efficacy and evidence base for these strategies is limited. 185 As detailed above, there are significant differences in the healing profiles of adult and fetal wounds. Recent therapies have attempted to reproduce fetal healing that is, regeneration, in adults.…”

Section: Chemokines As Therapeutic Targetsmentioning

confidence: 99%

Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring

Rees¹,

Greaves²,

Baguneid

et al. 2015

Advances in Wound Care

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Section: Chemokines As Therapeutic Targetsmentioning

confidence: 99%

Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring

Rees¹,

Greaves²,

Baguneid

et al. 2015

Advances in Wound Care

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“…116 Recombinant TGF-β3 appears to be useful for prophylaxis against and treatment of surgical scars. 117 …”

Section: Transforming Growth Factor-βmentioning

confidence: 99%

Scar Management in the Pediatric and Adolescent Populations

Krakowski

Totri

Donelan³

et al. 2016

Pediatrics

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For most children and adolescents who have developed symptomatic scars, cosmetic concerns are only a portion of the motivation that drives them and their caregivers to obtain treatment. In addition to the potential for cosmetic disfigurement, scars may be associated with a number of physical comorbidities including hypertrichosis, dyshidrosis, tenderness/pain, pruritus, dysesthesias, and functional impairments such as contractures, all of which may be compounded by psychosocial factors. Although a plethora of options for treating scars exists, specific management guidelines for the pediatric and adolescent populations do not, and evidence must be extrapolated from adult studies. New modalities such as the scar team approach, autologous fat transfer, and ablative fractional laser resurfacing suggest a promising future for children who suffer symptomatically from their scars. In this state-of-the-art review, we summarize cutting-edge scar treatment strategies as they relate to the pediatric and adolescent populations.

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“…Although abnormal scar formation can lead to functional, cosmetic and physiological problems, the physiopathology of such scar formation still remains a mystery 6 . Abnormal scar formation has been attributed to a high skin tension, genetic factors, increases in the extracellular matrix, a long duration of healing, and hormonal factors [10][11][12][13] . The most commonly investigated hormonal factor is estrogen, which affects wound healing by regulating the expression of various genes associated with regeneration, matrix production, epidermal function, and inflammation 13 .…”

Section: Discussionmentioning

confidence: 99%

Factors affecting the development of scar formation in abdominal surgery performed for gynecologic and obstetric conditions

Aydoğmuş¹,

Kelekci²,

Şengül³

et al. 2017

TURKDERM

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Background and Design:The aim of this study is to investigate whether there can be a difference in types of scars developed on the same type of incisions due to cesarean section or benign gynecologic operations, and to examine the effect of regenerative process occurring in the puerperal period on scar formation. Materials and Methods: A total of 586 female patients aged 20-40 years, who applied to our dermatology and gynecology and obstetrics outpatient clinics, were included in this case control study. Patients who were operated due to benign gynecologic conditions were assigned to group 1 (n=293), and those who underwent cesarean section to group 2 (n=293), and the types of scars were compared. A p value of less than 0.05 was considered statistically significant. Results: Atrophic and hypertrophic scars were developed in 237 (80.9%) and 56 (19.1%) of group 1 patients, respectively. However, 245 (83.6%) of patients in group 2 had atrophic scars and 48 (16.4%) had hypertrophic scars. In terms of the type of scar distribution, no significant difference was found between the two groups (p>0.05). Patients with hypertrophic scar formation constituted 53.8% of group 1 patients and 46.2% of group 2 patients. There was no significant difference between the groups for the risk of hypertrophic scar formation (p>0.05) Conclusion: Our study concluded that there is no significant difference in scar formation on abdominal incision site between benign gynecologic surgeries performed at any period of childbearing age and cesarean section. In addition, the presence of striae, wound infection or hematoma, and duration of wound healing were found to be associated with the risk for hypertrophic scar formation in incision sites in both cesarean section and benign gynecological operations. 2017;51:12-7

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Cutaneous scarring: Pathophysiology, molecular mechanisms, and scar reduction therapeutics

Cited by 159 publications

References 98 publications

Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring

Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring

Scar Management in the Pediatric and Adolescent Populations

Factors affecting the development of scar formation in abdominal surgery performed for gynecologic and obstetric conditions

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