Cutaneous<scp>T</scp>‐cell lymphoma in patients with chronic lymphocytic leukemia: clinical characteristics, temporal relationships, and survival data in a series of 14 patients at<scp>M</scp>ayo<scp>C</scp>linic

Chang, Michael; Weaver, Amy L.; Brewer, Jerry D.

doi:10.1111/ijd.12063

Cited by 10 publications

(14 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is the first known case of coexistent cutaneous CLL and LyP within the same skin biopsy. As stated previously, these conditions have been described before in the same patient, but not concurrently in the same tissue . This raises an important question: is this patient predisposed to multiple coexisting hematologic/lymphoproliferative malignancies, or are there other complicating factors at play such as his treatment for his known CLL?…”

Section: Discussionmentioning

confidence: 58%

“…But most of these theories are far to be confirmed . Chang et al examined the temporal relationships and survival of a group of 14 patients with coexisting CTCL and CLL. They determined that in patients whose CTCL precedes the CLL, the overall survival is worse.…”

Section: Discussionmentioning

confidence: 99%

“…2,41 The more recently described eosinophilic dermatosis of hematologic malignancy has also been seen in CLL/SLL. 42 Patients with CLL/SLL also can present in association with MF, 43 -45 Sezary syndrome, 44,46 cutaneous natural-killer (NK) cell lymphoma 44 and peripheral T-cell lymphoma NOS (not otherwise specified). 44 This is the first known case of coexistent cutaneous CLL and LyP within the same skin biopsy.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A unique case of concurrent chronic lymphocytic leukemia/small lymphocytic lymphoma and lymphomatoid papulosis in the same biopsy

et al. 2015

View full text Add to dashboard Cite

Chronic lymphocytic leukemia (CLL/SLL) is the most common leukemia in the western world and its cutaneous dissemination a very uncommon phenomenon. Lymphomatoid papulosis (LyP) is a CD30+ lymphoproliferative disorder characterized by chronic, recurrent and self healing skin lesions. Up to 20% of patients with LyP have a coexistent lymphoma. While the association between the two entities has been reported, their coexistence has never been documented. We describe a 74-year-old man with known CLL and thrombocytopenia who presented with a 2 year history of recurrent nodules and plaques to both arms and legs that resolved within 4-6 weeks after administration of rituximab and bendamustin for his CLL treatment. His biopsies showed an atypical lymphoid infiltrate, composed of large and pleomorphic cells with a nodular and interstitial pattern in a background of eosinophils. Immunohistochemical staining revealed a pattern of two separate yet coexisting neoplastic processes; a large CD30 positive T-cell lymphoproliferative disorder, while the other one was diagnostic of a neoplastic B-cell process (leukemia cutis). A diagnosis of coexistent LyP and cutaneous involvement by CLL/SLL was rendered. The simultaneous presence of both disorders can be a pitfall in the differential diagnosis of large cell lymphomas, such as Richter's transformation of CLL/SLL.

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A unique case of concurrent chronic lymphocytic leukemia/small lymphocytic lymphoma and lymphomatoid papulosis in the same biopsy

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Indeed, the coexistence of cutaneous T-cell lymphomas (CTCL) and low grade B-cell lymphomas, most commonly chronic lymphocytic leukemia (CLL), further exemplifies the complex pathogenesis underlying the proliferation of 2 distinct lineages and reinforces that the mechanisms behind this phenomenon are likely multifactorial. Chang et al, 15 in their review of 14 patients with CTCL and CLL, presented 8 patients in which both diseases were diagnosed concurrently, 5 in which CLL was diagnosed first, and 1 in which CTCL was diagnosed first. Antecedent viral infection, previous radiotherapy for breast cancer, and eventual development of prostate cancer were but a few examples of associations seen in their patients, supporting the theory of multifaceted pathogenetic mechanisms linking multi-lineage proliferation.…”

Section: Discussionmentioning

confidence: 99%

A Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder Arising in a Patient With Multiple Myeloma and Cutaneous Amyloidosis

Romano

Cohen

Howard

et al. 2016

The American Journal of Dermatopathology

View full text Add to dashboard Cite

CD30-positive cutaneous lymphoproliferative disorders, a group of T-cell neoplasms, including lymphomatoid papulosis (LyP) and cutaneous anaplastic large cell lymphoma, require careful clinicopathologic correlation for diagnosis. An association between LyP and the development of a second hematolymphoid malignancy has been established in the literature. LyP has also been reported with systemic amyloidosis, but no such reports have documented coexisting cutaneous amyloid deposition with LyP to our knowledge. A 66-year-old woman with cutaneous amyloidosis, secondary to multiple myeloma, in remission, presented with erythematous and dark-brown papules involving the right arm, scalp, and torso. Punch biopsy of the arm showed a dermal infiltrate of intermediate-sized lymphocytes, some of which displayed a plasmacytoid morphology and prominent nodular subepidermal amyloid deposition. Punch biopsy of the scalp similarly showed a nonepidermotropic dense dermal infiltrate of intermediate-sized plasmacytoid lymphocytes and multifocal amyloid deposition. Both infiltrates were immunophenotypically CD30-positive, anaplastic lymphoma kinase-negative T-cell lymphoproliferative processes. Subsequent studies showed no systemic involvement, and clinical correlation suggested a final diagnosis of LyP. We present this case of LyP, which histologically mimics a B-cell proliferation with a plasmacytoid morphology arising in association with cutaneous amyloidosis to highlight the importance of clinicopathologic correlation, a thorough battery of immunohistochemical studies, and consideration for a second hematologic malignancy arising in the setting of LyP.

show abstract

“…[13][14][15][16][17][18] Additionally, an association of B-CLL and various cutaneous T-cell lymphomas has been documented, including MF, Sézary syndrome, peripheral T-cell lymphoma involving the skin, and natural killer-cell lymphoma. [19][20][21] Occurrence of leukemic infiltrates on the site of a previous herpes simplex or herpes zoster infection leads to the speculation that specific skin infiltrates of B-CLL can be triggered by antigenic stimulation. [2][3][4][5]22 We are aware of 2 previously published articles documenting the association of specific B-CLL infiltrates and B. burgdorferi infection.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Borreliosis With a T-Cell–Rich Infiltrate and Simultaneous Involvement by B-Cell Chronic Lymphocytic Leukemia With t(14;18)(q32;q21)

Kempf¹,

Kazakov

Hübscher

et al. 2015

The American Journal of Dermatopathology

View full text Add to dashboard Cite

: Pseudolymphomatous infiltrates in Borrelia infection of the skin most commonly manifest with dense B-cell infiltrates and plasma cells. Cutaneous infiltrates of B-cell chronic lymphocytic leukemia (B-CLL) may accumulate at sites of infection, including Borrelia infection. We report an unusual constellation in a patient with synchronously diagnosed B-CLL and Borrelia infection of skin presenting with a dense dermal T-cell-rich infiltrate masking specific leukemic infiltrates of neoplastic B cells in the context of B-CLL harboring t(14;18)(q32;q21). Specific cutaneous involvement by B-CLL was confirmed by the detection of t(14;18)(q32;q21) (BCL2-IGH) using FISH in neoplastic B cells within the skin infiltrates. Borrelia burgdorferi (sensu lato) DNA detected by nested polymerase chain reaction in the skin biopsy and serological findings proved Borrelia infection. Complete resolution of the cutaneous infiltrates was observed after antibiotic treatment. This case demonstrates that Borrelia infection of the skin may present with dense T-cell-rich infiltrates mimicking cutaneous T-cell lymphoma and masking the synchronous presence of neoplastic B cells in the context of B-CLL.

show abstract

CutaneousT‐cell lymphoma in patients with chronic lymphocytic leukemia: clinical characteristics, temporal relationships, and survival data in a series of 14 patients atMayoClinic

Abstract: Patients with CTCL concurrent with or prior to CLL have a worse overall survival than patients with CLL in whom CTCL later develops. Larger studies are needed.

Cited by 10 publications

References 29 publications

A unique case of concurrent chronic lymphocytic leukemia/small lymphocytic lymphoma and lymphomatoid papulosis in the same biopsy

A unique case of concurrent chronic lymphocytic leukemia/small lymphocytic lymphoma and lymphomatoid papulosis in the same biopsy

A Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder Arising in a Patient With Multiple Myeloma and Cutaneous Amyloidosis

Cutaneous Borreliosis With a T-Cell–Rich Infiltrate and Simultaneous Involvement by B-Cell Chronic Lymphocytic Leukemia With t(14;18)(q32;q21)

Contact Info

Product

Resources

About