Cutaneous Sensitivity Reactions to Chlorpromazine

Role of <i>in viv</i><i>o</i>- and <i>in vitr</i><i>o</i>-formed Decomposition Products of Sulfanilamides and Phenothiazines in Photoallergy; Relationship of Spectrophotometric Findings to <i>in vivo</i> Reactions

“…Baer and Harber feel that following ingestion of a drug (internal sensitization) the eczcmatogens responsible for a photoallergic reaction may be formed by an unknown internal mechanism elsewhere in the body other than in the skin (1). Mullins suggests that the use of patch tests is therefore of little value in deter mining whether or not a patient might react to chlorpromazine ad ministered systematically (15).…”

The tranquilizing drugs.

“…In Cohen's (37) series the incidence was 8 per cent. While the most common reaction is a localized or generalized maculopapular eruption, almost all types of cutaneous eruptions can occur, according to Mullins and Farrington (126), with the exception of mucous membrane involvement. In their series (126) the eruption occurred in patients getting 400 mg. or more daily.…”

“…While the most common reaction is a localized or generalized maculopapular eruption, almost all types of cutaneous eruptions can occur, according to Mullins and Farrington (126), with the exception of mucous membrane involvement. In their series (126) the eruption occurred in patients getting 400 mg. or more daily. Cohen (37) feels that these manifestations are on an allergic basis and are unrelated to level of dosage.…”