Cutaneous squamous cell carcinoma of the scalp extending to the skull: A case report and review of the literature

Handler, Marc Z.; Goldberg, Judith D.

doi:10.1111/jocd.12378

Cited by 13 publications

(29 citation statements)

References 6 publications

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“…Its incidence is poorly defined 48 , though like for OSCC, it is increasing. Prognosis is poor for OSCC and also for the <5% of cSCC that is metastatic to regional lymph nodes 49–52 . Genetic stratification for both tumours is improving; for OSCC on The Cancer Genome Atlas (TCGA; a collection of >20,000 extensively-characterised primary tumours spanning 33 cancer types) and for cSCC in the literature 51,53 .…”

Section: Resultsmentioning

confidence: 99%

Development and validation of a targeted gene sequencing panel for application to disparate cancers

McCabe

Gauthier

Chan

et al. 2019

Sci Rep

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Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology treatments based on a tumour’s molecular profile. We aimed to develop a targeted gene sequencing panel for application to disparate cancer types with particular focus on tumours of the head and neck, plus test for utility in liquid biopsy. The final panel designed through Roche/Nimblegen combined 451 cancer-associated genes (2.01 Mb target region). 136 patient DNA samples were collected for performance and application testing. Panel sensitivity and precision were measured using well-characterised DNA controls (n = 47), and specificity by Sanger sequencing of the Aryl Hydrocarbon Receptor Interacting Protein (AIP) gene in 89 patients. Assessment of liquid biopsy application employed a pool of synthetic circulating tumour DNA (ctDNA). Library preparation and sequencing were conducted on Illumina-based platforms prior to analysis with our accredited (ISO15189) bioinformatics pipeline. We achieved a mean coverage of 395x, with sensitivity and specificity of >99% and precision of >97%. Liquid biopsy revealed detection to 1.25% variant allele frequency. Application to head and neck tumours/cancers resulted in detection of mutations aligned to published databases. In conclusion, we have developed an analytically-validated panel for application to cancers of disparate types with utility in liquid biopsy.

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Section: Resultsmentioning

confidence: 99%

Development and validation of a targeted gene sequencing panel for application to disparate cancers

McCabe

Gauthier

Chan

et al. 2019

Sci Rep

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“…The role of human papillomavirus has been proposed to be involved in its pathogenesis 46,47 . Advanced age is associated to a higher risk of metastatic spreading 43 . SCC is reported to be more frequent in men than in women 1 .…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

“…In a large retrospective cohort study on 15 784 SCC inpatients, the scalp was the most common anatomic location accounting for 30.6% of the cases. Other authors reported a prevalence of SCCs around 16% among STs, and a metastatic spreading to cervical lymph nodes is estimated to be around 16% 43 . Mohs micrographic surgery is considered a good treatment option offering a 5‐year survival cure rate of 99%, compared with traditional surgery at 86%.…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

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Malignant cutaneous tumours of the scalp: always remember to examine the head

Dika

Patrizi

Veronesi

et al. 2020

Acad Dermatol Venereol

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Around 2% of cutaneous neoplasms arise in the scalp (scalp tumours: STs). They can be classified as primary STs (epithelial, melanocytic and adnexal) or metastatic (from distal tumours or as a spreading from contiguous structures). This anatomic location is usually poorly examined during dermatological consultations, also due to the presence of the hair cover. Moreover, self-examination of the hair-covered skin is often harder for the patient. The peculiar features of the scalp may explain the worse prognosis of STs compared with neoplasms of other locations. The hair coverage protects the scalp from UV radiations, but due to the complex pathogenesis of STs, they may also develop in younger patients. Until now, STs have been not extensively investigated in the dermatological literature, and most publications are written by otolaryngologists, or by head, neck and plastic surgeons. Thus, dermatologists above all have the opportunity and the task to explore the scalp carefully, with the opportunity to make an early diagnosis, possibly changing the patient's prognosis. The aim of this paper was to review the main STs in order to increase awareness among dermatology specialists.

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“…Among tumors of the scalp, 16.6% are squamous cell carcinoma, making SCC the second most prevalent, after basal cell carcinoma [2]. In addition to increased age, risk factors for scalp SCC include chronic scarring, actinic damage, and a history of ionizing radiation [3].…”

mentioning

confidence: 99%