Cutaneous syringoma: A clinicopathologic study of 34 new cases and review of the literature

Abstract

Background:Syringoma is a benign adnexal tumor derived from intraepidermal eccrine duct.Aim:The aim of the study is to report the experience concerning syringoma by reviewing the clinical and histopathologic features of a series of 34 histologically diagnosed syringoma patients observed over a period of six years.Materials and Methods:Thirty-four patients were sorted into two groups, localized and generalized syringoma, according to the Friedman and Butler classification. Different histopathologic findings were recorded in specially designed questionnaires for further analysis.Results:Ninety-seven percent of the patients were females with the mean age of 27.6 years. The mean duration of the lesions before the presentations was six years. The diagnosis of syringoma was only considered in 23 patients (67.6%) and was the initial diagnosis in only 13 (38.2%) patients. All histological findings were seen more common in our cases. in comparison to the documented cases in the literature. Clear cell change of epithelial eccrine cells was 85.2% and there was no difference in the histopathological findings in the two groups. Our patients with generalized syringoma (GS) had a considerable lower age of onset than the ones with localized syringoma (LS) (P = 0.027).Conclusion:Our patients with generalized syringoma were younger than the ones with localized syringoma. Distribution of the generalized syringoma was mainly in the chest and neck followed by the forearms whereas localized syringoma was mostly confined to the face, axilla and genitalia. There were also some conditions associated with our cases including sarcoidosis, calcinosis cutis and basal cell carcinoma.

A study on spectrum of periorbital dermatoses in a tertiary centre

“…10 In our study majority of patients with syringoma were in fourth decade with mean age of 41.60, in contrast to the study by Alireza and Mohsen. 11 Females were (4) more commonly affected than males (1) in our study with ratio of 5:1, similar to study conducted by AlAradi et al 12 Palpebral syringomas are a common cutaneous pathology in Down's syndrome but we did not observe any such association in the present study.…”

Asymptomatic Papular Eruption in a Teenage Boy

“…2,4 These lesions tend to appear in successive crops on anterior body surfaces, most often involving the neck, axillae, chest, abdomen, and genital region. 2,5 The clinical presentation is often not diagnostic, and histopathological examination may be necessary for definitive diagnosis. 2,5 Rare clinical variants of eruptive syringomas include a miliumlike syringoma 6 and a form mimicking urticaria pigmentosa.…”

“…2,5 The clinical presentation is often not diagnostic, and histopathological examination may be necessary for definitive diagnosis. 2,5 Rare clinical variants of eruptive syringomas include a miliumlike syringoma 6 and a form mimicking urticaria pigmentosa. 7,8 In the milium-like variant, the milium structure has been shown to be of eccrine duct origin.…”

“…2,7,8 Histologically, syringomas appear as well-circumscribed cystic lesions in the superficial dermis. 2 Two flattened layers of epithelial cells, often with pink or pale cytoplasm, 2 form nests and tubules 2,5 surrounded by a dense and collagenous stroma. 9 Cells comprising the tubules are generally of ductal differentiation and surround a central lumen of amorphous debris.…”

Periocular syringomas – Successful treatment with fractional CO2 laser

“…The most common type, however, is the sporadic localized one. The majority of these tumors arise in the head and neck region, and genital manifestation is rare [1][2][3][4] . In contrast to periocular syringomas, which are mostly asymptomatic, genital tumors may be associated with pruritus and pain [5] .…”