Cutaneous T‐cell lymphoma

Mycosis fungoides – a review of the management of 28 patients and of the recent literature

“…PUVA, which is generally well tolerated by patients 9 and is often used as initial treatment, was described by Gilchrist et al 31 . in 1976.…”

“…No single standard regime is used, and multiple drugs are often employed, including methotrexate, chlorambucil, and etoposide. They have been used in this situation in combination with PUVA and electron beam therapy 9 …”

“…The exact incidence is unclear; 9 it has been suggested that 1000 new cases occur yearly in the USA; 10 0.42 new cases per 100,000 population were reported in 1984 9 . The sex ratio in most series shows a 2 : 1 male predominance, with an average age of onset of 56 years.…”

“…6 A recent report has eliminated human herpesvirus-8 (HHV-8) as a pathogen, 7 whilst limited evidence exists for the role of human T-lymphotropic virus type 1 in MF and Sezary syndrome (SS). 8 The exact incidence is unclear; 9 it has been suggested that 1000 new cases occur yearly in the USA; 10 0.42 new cases per 100,000 population were reported in 1984. 9 The sex ratio in most series shows a 2 : 1 male predominance, with an average age of onset of 56 years.…”

“…8 The exact incidence is unclear; 9 it has been suggested that 1000 new cases occur yearly in the USA; 10 0.42 new cases per 100,000 population were reported in 1984. 9 The sex ratio in most series shows a 2 : 1 male predominance, with an average age of onset of 56 years. SS, 11 a distinctive erythrodermic leukemic variant of CTCL, described in 1892 by Besnier and Hallopeau, 12 is considered to consist of malignant T-helper cells in dynamic equilibrium between the skin and vascular compartments.…”