Cutaneous T-cell lymphoma, NK-cell lymphoma, and myeloid leukemia

DiCaudo, David J.

doi:10.1016/b978-0-7020-5527-0.00024-8

Cited by 1 publication

(2 citation statements)

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“…This group includes a spectrum of entities including LyP on the benign end of the spectrum and ALCL on the malignant end . LyP presents with self‐resolving recurrent crops of ulcerated nodules and papules, most frequently involving the trunk and limbs . ALCL may show similar histopathologic features but is differentiated from LyP by its presentation as persistent solitary or localized nodules or tumors .…”

Section: Discussionmentioning

confidence: 99%

“…LyP presents with self‐resolving recurrent crops of ulcerated nodules and papules, most frequently involving the trunk and limbs . ALCL may show similar histopathologic features but is differentiated from LyP by its presentation as persistent solitary or localized nodules or tumors . Spontaneous complete or partial regression of primary cutaneous ALCL has been reported in 42% of cases, and even though relapses occur, extracutaneous spread is rare …”

Section: Discussionmentioning

confidence: 99%

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Pseudocarcinomatous hyperplasia in anaplastic large cell lymphoma, a mimicker of poorly differentiated squamous cell carcinoma: report of a case and review of the literature

2015

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Pseudocarcinomatous hyperplasia can occasionally be observed in biopsies of CD30-positive lymphoproliferative disorders. It is important to be cognizant of this association, because epithelial hyperproliferation can overshadow large atypical lymphoid cells, leading to an erroneous diagnosis of squamous cell carcinoma (SCC) or keratoacanthoma. Herein, we present a case of anaplastic large cell lymphoma (ALCL) with pseudocarcinomatous hyperplasia simulating a poorly differentiated carcinoma and review the literature on this subject. Immunohistochemical staining with p63 helped delineate the infiltrating tongues of pseudocarcinomatous hyperplasia from the malignant infiltrate. We present this case to raise awareness of the potential for pseudocarcinomatous hyperplasia to occur in the setting of CD30+ lymphoproliferative disorders. Clinicians and dermatopathologists should consider the possibility of ALCL or lymphomatoid papulosis when examining lesions with features of inflamed SCC, especially if the tumor presents on a site or in a patient that is not typical of SCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%