Cutaneous T-cell lymphomas and their management strategies

Abstract

Cutaneous T-cell lymphomas (CTCLs) comprise a heterogeneous group of lymphoproliferative disorders characterized by the proliferation of skin-homing post-thymic T-cells. It is the second most common extranodal non-Hodgekin's lymphoma. Many variants of mycosis fungoides and CTCLs are known to date, differing in clinical, histological, and immunophenotypic characteristics. Oral involvement has also been reported rarely in CTCLs. Treatment depends on the disease stage or the type of variant. New insights into the disease and the number of emerging novel therapeutic options have made it an interesting area for dermatologists and medical oncologists.

Granulomatous slack skin presenting as diffuse poikiloderma and necrotic ulcers, with features of granulomatous vasculitis and response to oral prednisone, acitretin, and oral psoralen plus ultraviolet light therapy—A case report

“…There is good evidence that re-PUVA is effective for clearing skin lesions, particularly in early stages of the disease, and long-term remissions have been reported 2, 27, 28, 32, 33. Our patient exhibited a significant decrease in size and induration of the folds and a decrease in indurated plaques on the neck and trunk and further clearance of poikiloderma with re-PUVA.…”

“…Our patient continues to respond to oral PUVA and topical corticosteroids and is being monitored closely 2, 27, 28, 29, 30, 31, 32, 33, 36…”