Cutaneous γδ T-Cell Lymphoma With Bilateral Ocular and Adnexal Involvement

Shunmugam, Manoharan; Chan, Elsie; O’Brart, David; Moonim, Mufaddal; Stanford, Miles; Morley, Ana M. S.

doi:10.1001/archophthalmol.2011.317

Cited by 10 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Involvement of the CNS is very rare, only five published cases being identified by a recent review 9. Ocular adnexal involvement by PCGDTCL causing proptosis has been reported,10 11 but intraocular involvement has been reported in only one patient with bilateral non-granulomatous anterior uveitis 11. Involvement of the retina or ocular posterior segment has never previously been reported.…”

Section: Discussionmentioning

confidence: 99%

Gamma–delta T-cell lymphoma of skin, eye and brain presenting with visual loss

Jones¹,

Gibb

Irion

et al. 2017

BMJ Case Reports

View full text Add to dashboard Cite

A young man presented with rapid, predominantly right-sided visual loss with a background of multifocal skin lesions. Visual acuity was right hand movements, left 6/5 Snellen, deteriorating to 6/38. He showed panuveitis with bilateral multifocal retinal infiltrates and retinal vasculitis. Multifocal brain lesions were identified. Biopsy of both skin and vitreous showed atypical lymphocytes, and immunohistochemistry confirmed T-cell lymphoma of gamma-delta subtype. Management with the CODOX-M/IVAC polychemotherapy regimen achieved rapid response including resolution of intraocular changes and substantial improvement of visual acuity to right 6/7.5, left 6/6. However, he relapsed before planned stem cell transplantation. Salvage with the gemcitabine/dexamethasone/cisplatin regimen, although temporarily effective, was followed by further relapse including widespread brain involvement, and he succumbed 10 months after presentation.

show abstract

Section: Discussionmentioning

confidence: 99%

Gamma–delta T-cell lymphoma of skin, eye and brain presenting with visual loss

Jones¹,

Gibb

Irion

et al. 2017

BMJ Case Reports

View full text Add to dashboard Cite

show abstract

“…These are typically confined to the dermis, invade to deep subcutaneous areas, or have systemic involvement (e.g. ocular, adrenal, and lymph node) but rarely invade the CNS . Cutaneous γδ T‐cell lymphoma mimics many different subtypes of CTCL, including subcutaneous panniculitis like T‐cell lymphoma (alpha–beta type), pagetoid reticulosis, and MF and additionally mimics inflammatory conditions of the skin, including autoimmune disorders, panniculitis, cellulitis/pyroderma, and psoriasis .…”

Section: Discussionmentioning

confidence: 99%

“… M, male; F, female; CNS, central nerve system; CSA, cyclosporine; FND, fludarabine, Mitoxantrone, Dexamethasone; MOF, multiple organ failure; Ref No., reference number. Cases 2–5 were literature review from Refs respectively. …”

Section: Discussionmentioning

confidence: 99%

“…ocular, adrenal, and lymph node) but rarely invade the CNS. 3,8 Cutaneous γδ T-cell lymphoma mimics many different subtypes of CTCL, including subcutaneous panniculitis like T-cell lymphoma (alpha-beta type), pagetoid reticulosis, 9 and MF 3 and additionally mimics inflammatory conditions of the skin, including autoimmune disorders, 10 panniculitis, cellulitis/pyroderma, and psoriasis. 3 After a review of the literature, we found a total of five cases (including the current one) of cutaneous γδ T-cell lymphoma with CNS manifestations, of which three also reported peripheral nerve involvement.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous gamma‐delta T‐cell lymphoma with central nervous system involvement: report of a rarity with review of literature

et al. 2014

View full text Add to dashboard Cite

Primary cutaneous gamma-delta (γδ) T-cell lymphoma is an extremely rare and aggressive variant of cutaneous lymphoma. Central nervous system (CNS) involvement, a rare finding, and hemophagocytic syndrome are two complications that are commonly fatal. We describe a 58-year-old patient presenting with skin plaque who subsequently developed subcutaneous nodules diagnosed as cutaneous T-cell lymphoma (CTCL), clinically resembling 'mycosis fungoides'. The patient was treated with repeat topical radiation therapies but had frequent relapsed disease. Approximately 4.5 years after, the patient presented with third and sixth cranial nerve palsies and was found to have CNS involvement by lymphoma per positron emission tomography-computed tomography (PET/CT) and a biopsy of foramen magnum. Phenotypically, the tumor cells were CD3(+)/CD4(-)/CD8(-)/CD7(+)/CD5(-)/CD30(-)/TCRαβ(-)/TCRγδ(+). Despite aggressive strategies taken, the patient expired 3 months after the diagnosis of the CNS lesion. A retrospective investigation proved the original CTCL to be γδ T-cell in origin, confirming an indolent cutaneous γδ T-cell lymphoma with eventual CNS manifestation. We present this case to draw attention to the entity, which can occasionally present with misleading histopathologic and clinical features. In addition, we provide a review of the literature to summarize clinical and pathologic features of the reported similar cases.

show abstract

Ocular and Adnexal T-Cell Lymphoma

Wang

Chan

2013

Ocular and Adnexal Lymphoma

View full text Add to dashboard Cite

Cutaneous γδ T-Cell Lymphoma With Bilateral Ocular and Adnexal Involvement

Cited by 10 publications

References 6 publications

Gamma–delta T-cell lymphoma of skin, eye and brain presenting with visual loss

Gamma–delta T-cell lymphoma of skin, eye and brain presenting with visual loss

Cutaneous gamma‐delta T‐cell lymphoma with central nervous system involvement: report of a rarity with review of literature

Ocular and Adnexal T-Cell Lymphoma

Contact Info

Product

Resources

About