Cutting Edge: Monarch-1: A Pyrin/Nucleotide-Binding Domain/Leucine-Rich Repeat Protein That Controls Classical and Nonclassical MHC Class I Genes

Williams, Kristi; Taxman, Debra J.; Linhoff, Michael W.; Reed, William; Ting, Jenny P.‐Y.

doi:10.4049/jimmunol.170.11.5354

Cited by 87 publications

(77 citation statements)

References 23 publications

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“…This has been confirmed by us and others [17]. Thus an interesting proposition is that nitric oxide may serve as a negative feedback loop to induce Monarch-1 expression, which then attenuates an ongoing inflammatory response by inhibiting NF-κB activation as well as proinflammatory cytokine and chemokine expression.…”

Section: Monarch-1 Expressionsupporting

confidence: 65%

“…Monarch-1 is found to be expressed in monocytes and granulocytes with notably high expression in eosinophils, while a panel of over 70 tissues/cells shows little or no expression [16,17]. This myeloid restricted pattern of expression provided the initial clue that the protein may be a regulator of the immune response, inflammation and host response to pathogens.…”

Section: Monarch-1 Expressionmentioning

confidence: 98%

“…The full length sequence was first cloned and named PYPAF7 [16]. Simultaneously, we also cloned the full length sequence and named it CLR19.3 or Monarch-1 [17]. The gene is located on human chromosome 19q13.4, among a cluster of nine pyrin-containing CLR genes.…”

Section: The Monarch-1/pyapf7 Genementioning

confidence: 99%

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Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions

Lich

Ting

2007

Microbes and Infection

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CATERPILLER is a mammalian gene family with signature NBD and LRR domains. Several members of this family are positive regulators of inflammatory responses. Others, however, exert negative effects on proinflammatory responses. These data are particularly convincing when shRNA/ siRNA are used. This review focuses on the Monarch-1/PYPAF7 gene with brief discussions of CLR16.2/NOD3, PYPAF2/PAN1/NALP2, and PYPAF3.

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Section: Monarch-1 Expressionsupporting

confidence: 65%

Section: Monarch-1 Expressionmentioning

confidence: 98%

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Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions

Lich

Ting

2007

Microbes and Infection

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“…Interestingly, the PYHINs are not the only protein family with dual roles as innate immune sensors and transcriptional regulators. For example, the NLRs NLRC5 and NLRP12 have additional roles acting as transcriptional regulators of MHC class I, and the associated genes b2M, TAP1, and LMP2 [74,75]. Future work will likely reveal further gene regulatory roles for the PYHINs both as nucleic acid sensors and as downstream components of signal transduction pathways.…”

Section: Discussionmentioning

confidence: 99%

The emerging role of human PYHIN proteins in innate immunity: Implications for health and disease

Connolly

Bowie

2014

Biochemical Pharmacology

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“…Initial studies found that NLR family member CIITA could regulate the MHC class I gene activation through overexpression system in vitro (Martin et al, 1997;Williams et al, 2003). However, the expression of MHC class I genes was not affected in Ciita-defi cient mice (Chang et al, 1996), suggesting that there may be unidentifi ed regulators for MHC class I genes.…”

Section: Structure Of Nlrc5mentioning

confidence: 99%

Expression regulation and function of NLRC5

Yao

Qian

2013

Protein Cell

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The NOD like receptors (NLRs), a class of intracellular receptors that respond to pathogen attack or cellular stress, have gained increasing attention. NLRC5, the largest member of the NLR protein family, has recently been identified as a critical regulator of immune responses. While NLRC5 is constitutively and widely expressed, it can be dramatically induced by interferons during pathogen infections. Both in vitro and in vivo studies have demonstrated that NLRC5 is a specifi c and master regulator of major mistocompatibility complex (MHC) class I genes as well as related genes involved in MHC class I antigen presentation. The expression of MHC class I genes is regulated by NLRC5 in coordination with the RFX components through an enhanceosome-dependent manner. And the involvement of NLRC5 in MHC class I mediated CD8 + T cell activation, proliferation and cytotoxicity is proved to be critical for host defense against intracellular bacterial infections. Nevertheless, the role of NLRC5 in innate immunity remains to be further explored. Here, we review the research advances on the structure, expression regulation and function of NLRC5.

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Cutting Edge: Monarch-1: A Pyrin/Nucleotide-Binding Domain/Leucine-Rich Repeat Protein That Controls Classical and Nonclassical MHC Class I Genes

Abstract: Material

Cited by 87 publications

References 23 publications

Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions

Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions

The emerging role of human PYHIN proteins in innate immunity: Implications for health and disease

Expression regulation and function of NLRC5

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