Cutting Edge: Productive HIV-1 Infection of Dendritic Cells via Complement Receptor Type 3 (CR3, CD11b/CD18)

Bajtay, Zsuzsa; Speth, Cornelia; Erdei, Anna; Dierich, Manfred P.

doi:10.4049/jimmunol.173.8.4775

Cited by 85 publications

(97 citation statements)

References 29 publications

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“…Thus, the fI-mediated processing of C3b fragments on HIV to C3d may have in vivo relevance in the generation of C3d-coated HIV particles with high affinity for CR2 expressed on B cells (or on FDC) promoting an effective transmission of opsonized HIV to T cells. Of note, recent studies have demonstrated complement-mediated enhancement of productive HIV infection in human monocyte-derived dendritic cells (DC) (29). Therefore, processing of C3b fragments to iC3b on HIV might also be involved in the complement-mediated enhancement of HIV infection of monocyte-derived DC through binding of iC3b-coated virus to CR3 and CR4 expressed on DC.…”

Section: Discussionmentioning

confidence: 99%

Factor I-Mediated Processing of Complement Fragments on HIV Immune Complexes Targets HIV to CR2-Expressing B Cells and Facilitates B Cell-Mediated Transmission of Opsonized HIV to T Cells

Bánki

Wilflingseder

Ammann

et al. 2006

The Journal of Immunology

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Our study demonstrates that binding of complement-opsonized HIV to complement receptor type 1 on human erythrocytes (E) via C3b fragments is followed by a rapid normal human serum-mediated detachment of HIV from E. The release was dependent on the presence of factor I indicating a conversion of C3b fragments to iC3b and C3d on the viral surface. This in turn resulted in an efficient binding of opsonized HIV to CR2-expressing B cells, thus facilitating B cell-mediated transmission of HIV to T cells. These data provide a new dynamic view of complement opsonization of HIV, suggesting that association of virus with E might be a transient phenomenon and the factor I-mediated processing of C3b to iC3b and C3d on HIV targets the virus to complement receptor type 2-expressing cells. Thus, factor I in concert with CR1 on E and factor H in serum due to their cofactor activity are likely to be important contributors for the generation of C3d-opsonized infectious HIV reservoirs on follicular dendritic cells and/or B cells in HIV-infected individuals.

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Section: Discussionmentioning

confidence: 99%

Factor I-Mediated Processing of Complement Fragments on HIV Immune Complexes Targets HIV to CR2-Expressing B Cells and Facilitates B Cell-Mediated Transmission of Opsonized HIV to T Cells

Bánki

Wilflingseder

Ammann

et al. 2006

The Journal of Immunology

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“…A similar mechanism is observed in human mononuclear cell lines infected with HIV. CR3 and adhesion particles facilitates HIV-1 penetration into target cells (Stoiber et al 1997, Bajtay et al 2004, Bouhlal et al 2007. Similarly to humans, mTNFα could also be used by viral protein/proteins in cattle to modulate the TNF/TNFR signaling pathway and control BLV replication in CD11b+TNFα+p24+ cells.…”

Section: Discussionmentioning

confidence: 99%

Tumor necrosis factor-alpha (TNFα) gene polymorphism and expression of membrane-bound TNFα protein on CD11b+ and IgM+ cells in cows naturally infected with bovine leukemia virus

Bojarojć-Nosowicz¹,

Kaczmarczyk²,

Stachura³

et al. 2015

Polish Journal of Veterinary Sciences

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The aim of this study was to determine whether SNP at position -824 (promoter region) of the TNFα gene significantly differentiates the size of IgM+, CD5+ and CD11b+ cell subpopulations and affects the expression of membrane-bound TNFα protein (mTNFα) on these cells and their susceptibility to BLV infections.In this study, significant differences were determined for the first time between TNFα genotypes and the percentage of cells with the CD11b+TNFα+p24+ immunophenotype. Furthermore, greater expansion of lymphocytes with the IgM+TNFα+p24+ immunophenotype was reported in cows with the G/G genotype than in A/A homozygotes. Cells with the above immunophenotype were more frequently observed in cows with persistent leukocytosis than in aleukemic cattle.Our results suggest that polymorphism of the TNFα -824 A>G gene and mTNFα protein expression play an important role in the pathogenesis of enzootic bovine leukosis.

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“…Another macrophage cell surface receptor that has acquired multiple, relatively low-affinity ligand binding activities is the CR3 complement receptor, which recognizes a range of ligands, including opsonized bacteria and viruses, Leishmania surface antigens, intracellular adhesion molecule-1, and fibrinogen, and can also mediate macrophage adhesion (117,118).…”

Section: Why So Many Receptors? Why So Many Ligands?mentioning

confidence: 99%

Thematic review series: The Immune System and Atherogenesis. Recent insights into the biology of macrophage scavenger receptors

Greaves

Gordon

2005

Journal of Lipid Research

189

115

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Scavenger receptors were originally defined by their ability to bind and internalize modified lipoproteins. Macrophages express at least six structurally different cell surface receptors for modified forms of LDL that contribute to foam cell formation in atherosclerosis. In addition to their role in the pathology of atherosclerosis, macrophage scavenger receptors, especially SR-A, play critical roles in innate immunity, apoptotic cell clearance, and tissue homeostasis. In this review, we highlight recent advances in understanding the biology of macrophage scavenger receptors as pattern recognition receptors for both infectious nonself (pathogens) and modified self (apoptotic cells and modified LDL). We critically evaluate the potential of scavenger receptors and their ligands as targets for therapeutic intervention in human disease. -Greaves, D. R., and S. Gordon. MACROPHAGE-DERIVED FOAM CELLSFatty streaks, which are the earliest forms of atherosclerotic lesion visible in the artery wall, consist almost entirely of macrophage-derived foam cells (1-3). Monocytes that have been recruited to the subendothelial space at sites of endothelial cell activation differentiate into macrophages and express a range of scavenger receptors, which mediate the endocytic uptake of modified forms of LDL (4). Brown, Goldstein, and colleagues (5, 6) coined the term "scavenger receptor" to distinguish the uptake of modified LDL by macrophages from LDL uptake via the classical LDL receptor, which is feedback inhibited by the accumulation of cholesterol within the cell. Molecular cloning and biochemical characterization of the cellular receptors that mediate the uptake of modified forms of LDL have revealed an unexpectedly large number of endocytic receptors (7, 8). These membrane proteins have widely different structures, and all the scavenger receptors characterized to date bind a number of ligands of biological importance other than modified LDL. Even more puzzling is the recently described scavenger receptor SR-PSOX (scavenger receptor that binds phosphatidylserine and oxidized lipoprotein), which can act both as a receptor [for oxidized LDL (OxLDL)] and as a ligand (the membranebound CXC chemokine, CXCL16).Their lack of feedback inhibition by intracellular cholesterol has made macrophage scavenger receptors scapegoats for the development of macrophage foam cell formation in the artery wall, but it is important to recognize that other metabolic pathways play an important role in the development of cholesteryl ester deposits in macrophage foam cells. Modified apolipoprotein B (apoB)-containing lipoproteins taken up via scavenger receptors are delivered to lysosomes and hydrolyzed to release free cholesterol and fatty acids. The conversion of free cholesterol into cholesteryl esters in macrophages is catalyzed by the enzyme ACAT, and free cholesterol can be converted by the mitochondrial enzyme Cyp27 into 27-hydroxycholesterol, one of several oxysterols that activate changes in macrophage foam cell transcription via the nuc...

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Cutting Edge: Productive HIV-1 Infection of Dendritic Cells via Complement Receptor Type 3 (CR3, CD11b/CD18)

Cited by 85 publications

References 29 publications

Factor I-Mediated Processing of Complement Fragments on HIV Immune Complexes Targets HIV to CR2-Expressing B Cells and Facilitates B Cell-Mediated Transmission of Opsonized HIV to T Cells

Factor I-Mediated Processing of Complement Fragments on HIV Immune Complexes Targets HIV to CR2-Expressing B Cells and Facilitates B Cell-Mediated Transmission of Opsonized HIV to T Cells

Tumor necrosis factor-alpha (TNFα) gene polymorphism and expression of membrane-bound TNFα protein on CD11b+ and IgM+ cells in cows naturally infected with bovine leukemia virus

Thematic review series: The Immune System and Atherogenesis. Recent insights into the biology of macrophage scavenger receptors

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