CuZn Complex Used in Electrical Biosensors for Drug Delivery Systems

Abstract

This paper is to discuss the potential of using CuZn in an electrical biosensor drug carrier for drug delivery systems. CuZn is the main semiconductor ingredient that has great promise as an electrochemical detector to trigger releases of active pharmaceutical ingredients (API). This CuZn biosensor is produced with a green metal of frameworks, which is an anion node in conductive polymers linked by bioactive ligands using metal–polymerisation technology. The studies of Cu, Zn, and their oxides are highlighted by their electrochemical performance as electrical biosensors to electrically trigger API. The three main problems, which are glucose oxidisation, binding affinity, and toxicity, are highlighted, and their solutions are given. Moreover, their biocompatibilities, therapeutic efficacies, and drug delivery efficiencies are discussed with details given. Our three previous investigations of CuZn found results similar to those of other authors’ in terms of multiphases, polymerisation, and structure. This affirms that our research is on the right track, especially that related to green synthesis using plant extract, CuZn as a nanochip electric biosensor, and bioactive ligands to bind API, which are limited to the innermost circle of the non-enzymatic glucose sensor category.

Relationship between Osteosarcoma Therapy and Tumorigenesis, Metastasis, Immune Evasion, and Chemoresistance

“…Therefore, combinational and targeted therapies [22] [23] are developed for these problems and has a higher response rate [24]. However, their evidence of efficacy, long-term use [25], and personalised precision medicine [26] remain inadequate [27]. There is some evidence showing that immunosuppressive and chemotherapeutic resistance (chemoresistance) developed into immune evasion and multidrug resistance (MDR), respectively [28][29] [30].…”

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

“…Copper and zinc in metal-organic framework loading with drugs and their performances. Despite CuZn being an electrical biosensor, it uses an endogenous enzymatic biosensor to stimulate drug release [37]. Thus, both biosensors have been identified as an alternative use of MBD compared to cisplatin [133].…”

“…The reality is that this and other functions of biosensors could not be elaborated due to space limitations. As a result, those interested can find more information in our papers [36][37]. This is the rationale for developing a biosensor with sustained efficacy and minimal adverse effects.…”

“…In our previous paper, we presented some evidence of combinational and targeted biosensors to trigger and stimulate drug release [36]. Our efforts to develop a multifunctional biosensor for OS therapy (OST), however, will be insufficient unless we investigate the physiological functions of CuZn [37]. On the contrary, not much research on CuZn has successfully provided details of multifunctional biosensors for balancing and controlling drug release during cancer invasion [34].…”

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

“…In our previous paper, we presented some evidence of combinational and targeted biosensors to trigger and stimulate drug release [ 35 ]. Our efforts to develop a multifunctional biosensor for OST, however, will be insufficient unless we investigate the physiological functions of CuZn [ 36 ]. On the contrary, not much research on CuZn has successfully provided details of multifunctional biosensors for balancing and controlling drug release during cancer invasion [ 33 ].…”