CXC-chemokines stimulate invasion and chemotaxis in prostate carcinoma cells through the CXCR2 receptor

Interleukin-8 promotes cell migration through integrin αvβ6 upregulation in colorectal cancer

“…Meanwhile it should be noted that, other mechanisms including AP-1, NF-κB, STAT-3 and β-catenin signaling pathways could also be involved in IL-8-induced tumor migration [9]. IL-8 stimulated invasion of prostate cancer in part by altering the activation state of the β1 integrins [51]. In human chondrosarcoma, IL-8 enhanced cell motility by increasing αvβ3 integrin expression [52].…”

A role for aberrantly expressed nuclear localized decorin in migration and invasion of dysplastic and malignant oral epithelial cells

“…Increased expression of IL-8 and/or its receptors has been characterized in cancer cells, endothelial cells, infiltrating neutrophils, and tumor-associated macrophages, suggesting that IL-8 may function as a significant regulatory factor within the tumor microenvironment. Many tumor cells, such as prostate carcinoma, melanoma, breast carcinoma and gastric carcinoma cell lines, respond chemotactically to IL-8 [30-34]. IL-8 can also act as an autocrine growth factor for melanoma, colon carcinoma, lung adenocarcinoma and prostate carcinoma cell lines [35-38].…”

Deregulation of HIF1-alpha and hypoxia-regulated pathways in hepatocellular carcinoma and corresponding non-malignant liver tissue—influence of a modulated host stroma on the prognosis of HCC

“…ICAM1 and the chemotactic cytokine interleukin-8 (IL-8) can both be activated by reactive oxygen species and act in a canonical pathway fashion downstream of HIF1A. Together, IL-8 and ICAM1 orchestrate the migration, adhesion, and invasion of cells [27,28]. Furthermore, there is substantial evidence that the interaction between chemokines (i.e., CCL20) and their receptor (i.e., CCR6) participate in the regulation of complex physiological functions essential for cancer cells migration and metastases [29].…”