CXCL14 regulates cell proliferation, invasion, migration and epithelial-mesenchymal transition of oral squamous cell carcinoma

Liang, Rong; Wang, Lie; Yi, Shuhua; Guo, Hongyan; Liu, Ke

doi:10.1080/13102818.2019.1664930

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…CXCL14 has been shown to be expressed in the mouse limbus in development and adulthood, where it has been suggested that it may regulate the formation of limbal stem cells 22 . It has also been shown to regulate cell proliferation, invasion, and migrations of oral squamous carcinomas 29 , which may point to a role in the modulation of epithelial stem cell cycle rate. Additionally, it has been shown to have an important role in the inhibition of angiogenesis 30 , so it may help define the border between cornea and conjunctiva.…”

Section: Discussionmentioning

confidence: 99%

Single nuclei transcriptomics of the in situ human limbal stem cell niche

Davidson,

Sung,

Brown

et al. 2024

Sci Rep

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The corneal epithelium acts as a barrier to pathogens entering the eye; corneal epithelial cells are continuously renewed by uni-potent, quiescent limbal stem cells (LSCs) located at the limbus, where the cornea transitions to conjunctiva. There has yet to be a consensus on LSC markers and their transcriptome profile is not fully understood, which may be due to using cadaveric tissue without an intact stem cell niche for transcriptomics. In this study, we addressed this problem by using single nuclei RNA sequencing (snRNAseq) on healthy human limbal tissue that was immediately snap-frozen after excision from patients undergoing cataract surgery. We identified the quiescent LSCs as a sub-population of corneal epithelial cells with a low level of total transcript counts. Moreover, TP63, KRT15, CXCL14, and ITGβ4 were found to be highly expressed in LSCs and transiently amplifying cells (TACs), which constitute the corneal epithelial progenitor populations at the limbus. The surface markers SLC6A6 and ITGβ4 could be used to enrich human corneal epithelial cell progenitors, which were also found to specifically express the putative limbal progenitor cell markers MMP10 and AC093496.1.

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Section: Discussionmentioning

confidence: 99%

Single nuclei transcriptomics of the in situ human limbal stem cell niche

Davidson,

Sung,

Brown

et al. 2024

Sci Rep

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“…CXCL14 was found to completely block OSCC establishment in SCID mouse xenografts [ 42 ]. A more recent study, explained that the anti-tumor functions exerted by CXCL14 are carried out by means of supressing PD-L1 expression and NF- k B mediated EMT [ 43 ]. Periodontal pathogen P. gingivalis is able to stimulate the expression of the CXCL14 from oral epithelial cells both directly and by antagonizing epidermal growth factor (EGF)-induced activation of the MEK-ERK1/2 pathway known to repress CXCL14 transcription [ 44 ].…”

Section: Periodontal Pathogens and The Host Responses: War And Trucementioning

confidence: 99%

The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities

Elebyary

Barbour

Fine

et al. 2021

Front. Oral. Health

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Periodontitis (PD) is increasingly considered to interact with and promote a number of inflammatory diseases, including cancer. In the case of oral squamous cell carcinoma (OSCC) the local inflammatory response associated with PD is capable of triggering altered cellular events that can promote cancer cell invasion and proliferation of existing primary oral carcinomas as well as supporting the seeding of metastatic tumor cells into the gingival tissue giving rise to secondary tumors. Both the immune and stromal components of the periodontium exhibit phenotypic alterations and functional differences during PD that result in a microenvironment that favors cancer progression. The inflammatory milieu in PD is ideal for cancer cell seeding, migration, proliferation and immune escape. Understanding the interactions governing this attenuated anti-tumor immune response is vital to unveil unexplored preventive or therapeutic possibilities. Here we review the many commonalities between the oral-inflammatory microenvironment in PD and oral-inflammatory responses that are associated with OSCC progression, and how these conditions can act to promote and sustain the hallmarks of cancer.

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scDiffCoAM: A complete framework to identify potential biomarkers for esophageal squamous cell carcinoma using scRNA-Seq data analysis

Saikia,

Bhattacharyya,

Kalita

2024

J Biosci

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CXCL14 regulates cell proliferation, invasion, migration and epithelial-mesenchymal transition of oral squamous cell carcinoma

Abstract: View related articlesView Crossmark data Citing articles: 1 View citing articles CXCL14 regulates cell proliferation, invasion, migration and epithelial-mesenchymal transition of oral squamous cell carcinoma

Cited by 4 publications

References 32 publications

Single nuclei transcriptomics of the in situ human limbal stem cell niche

Single nuclei transcriptomics of the in situ human limbal stem cell niche

The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities

scDiffCoAM: A complete framework to identify potential biomarkers for esophageal squamous cell carcinoma using scRNA-Seq data analysis

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