CXCL8, CXCL9, and CXCL10 serum levels increase in syphilitic patients with seroresistance

Dong, Xiaoyan; Zhang, Ruoyu; Yang, Fangfang; Liu, Jinlin; Peng, Yumeng; Ge, Yumei

doi:10.1002/jcla.24016

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…The clinical laboratory is certified according to the international standards for laboratories 15,189, and internal quality control procedures and external quality assessment schemes were used to guarantee the quality of the data. 17 …”

Section: Methodsmentioning

confidence: 99%

Serum Interleukin-26 is a Potential Biomarker for the Differential Diagnosis of Neurosyphilis and Syphilis at Other Stages

Shen¹,

Dong²,

Liu³

et al. 2022

IDR

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Background Interleukin-26 (IL-26) is an atypical proinflammatory cytokine due to its binding to circulating double-stranded DNA and direct antibacterial activity. Although IL-26 has been confirmed to be involved in the pathophysiology of cancer, chronic inflammatory diseases and infections, the diagnostic and prognostic values of IL-26 levels in syphilis patients are not clear. This study aimed to investigate IL-26 levels in different stages of syphilis progression. Methods A total of 30 healthy controls and 166 patients with syphilis at different stages of disease progression were enrolled. Serum IL-26 levels were quantified in accordance with the protocols of RayBio ® Human Interleukin-26 Enzyme Linked Immunosorbent Assay (ELISA) kits. Clinical laboratory diagnostic parameters and blood analysis data were detected and collected according to clinical medical laboratory standards. Results The levels of serum IL-26 were significantly higher in neurosyphilis patients than in healthy subjects (6.87 (4.36, 12.14) and 1.67 (0.09, 4.89) pg/μL, respectively; ****p < 0.0001), latent syphilis (1.48 (0.40, 2.05) pg/μL, ****p < 0.0001), seroresistant syphilis (0.81 (0.20, 2.91) pg/μL, ****p < 0.0001) and secondary syphilis (1.66 (0.41, 4.25) pg/μL, ****p < 0.0001) with data presented as the median with interquartile range. The concentration of serum IL-26 was most sensitive to serum low-density lipoprotein concentration (r = −0.438, **p = 0.004) in latent syphilis, urine epithelial cells (r = 0.459, **p = 0.003) in seroresistant syphilis, and serum creatinine levels (r = 0.463, **p = 0.004) and urea creatinine ratio levels (r = 0.500, **p = 0.008) in secondary syphilis patients. There was no significant correlation with the concentration of IL-26 and toluidine red unheated serum test (TRUST) titers in each type of syphilis patient. Conclusion Circulating IL-26 in serum displays diagnostic potential in the progression of neurosyphilis and warrants further evaluation in clinical trials.

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Section: Methodsmentioning

confidence: 99%

Serum Interleukin-26 is a Potential Biomarker for the Differential Diagnosis of Neurosyphilis and Syphilis at Other Stages

Shen¹,

Dong²,

Liu³

et al. 2022

IDR

Self Cite

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“…In the scientific literature, a role of this class of molecules in viral infections has been recognized; these would seem to act as a sort of obstacle for the entry of viral particles as well as subsequently inhibit proliferation, regulate apoptosis and, as previously mentioned, modulate the immune response. Among several cytokines, the ones most involved in viral infections, especially at the respiratory level, seem to be CXCL10 and CXCL8 (Dong et al., 2021). Usually, following a viral infection, the chemokines in circulation increase to counteract the disease, but it can also happen that the virus interferes with the cytokine/receptor system in its favor to modify the different intracellular pathways by increasing the viral replication rate (Alcami, 2016).…”

Section: Covid‐19 and Chemokinesmentioning

confidence: 99%

Can alpha‐linolenic acid be a modulator of “cytokine storm,” oxidative stress and immune response in SARS‐CoV‐2 infection?

Cianciosi,

Diaz,

Gaddi

et al. 2023

Food Frontiers

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Alpha‐linolenic acid (ALA) is a long‐chain polyunsaturated essential fatty acid of the Ω3 series found mainly in vegetables, especially in the fatty part of oilseeds, dried fruit, berries, and legumes. It is very popular for its preventive use in several diseases: It seems to reduce the risk of the onset or decrease some phenomena related to inflammation, oxidative stress, and conditions of dysregulation of the immune response. Recent studies have confirmed these unhealthy situations also in patients with severe coronavirus disease 2019 (COVID‐19). Different findings (in vitro, in vivo, and clinical ones), summarized and analyzed in this review, have showed an important role of ALA in other various non‐COVID physiological and pathological situations against “cytokines storm,” chemokines secretion, oxidative stress, and dysregulation of immune cells that are also involved in the infection of the 2019 novel coronavirus. According to the effects of ALA against all the aforementioned situations (also present in patients with a severe clinical picture of severe acute respiratory syndrome‐(CoV‐2) infection), there may be the biologic plausibility of a prophylactic effect of this compound against COVID‐19 symptoms and fatality.

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“…CXCL13 has other interesting applications, including treatment monitoring in neurosyphilis [ 36 ]. Elevated concentrations of CXCL8, CXCL10, and IL-10 may also be potential biological markers of neurosyphilis, especially asymptomatic neurosyphilis [ 37 – 39 ]. Meanwhile, the increased levels of CXCL9, CXCL7, CCL24, IL-17, IL-26, and migration inhibitory factor (MIF) of macrophages in the CSF of neurosyphilis patients suggested their role as promising differential diagnostic tools for neurosyphilis [ 37 , 40 – 42 ].…”

Section: Diagnosismentioning

confidence: 99%

“…Elevated concentrations of CXCL8, CXCL10, and IL-10 may also be potential biological markers of neurosyphilis, especially asymptomatic neurosyphilis [ 37 – 39 ]. Meanwhile, the increased levels of CXCL9, CXCL7, CCL24, IL-17, IL-26, and migration inhibitory factor (MIF) of macrophages in the CSF of neurosyphilis patients suggested their role as promising differential diagnostic tools for neurosyphilis [ 37 , 40 – 42 ]. Although these cytokine changes are still in their infancy for the diagnosis of neurosyphilis, their importance cannot be ignored due to the lack of ideal neurosyphilis biomarkers.…”

Section: Diagnosismentioning

confidence: 99%

Resurgence of syphilis: focusing on emerging clinical strategies and preclinical models

Xiong,

Liu,

Zhang

et al. 2023

J Transl Med

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Syphilis, a sexually transmitted disease (STD) caused by Treponema pallidum (T. pallidum), has had a worldwide resurgence in recent years and remains a public health threat. As such, there has been a great deal of research into clinical strategies for the disease, including diagnostic biomarkers and possible strategies for treatment and prevention. Although serological testing remains the predominant laboratory diagnostic method for syphilis, it is worth noting that investigations pertaining to the DNA of T. pallidum, non-coding RNAs (ncRNAs), chemokines, and metabolites in peripheral blood, cerebrospinal fluid, and other bodily fluids have the potential to offer novel perspectives on the diagnosis of syphilis. In addition, the global spread of antibiotic resistance, such as macrolides and tetracyclines, has posed significant challenges for the treatment of syphilis. Fortunately, there is still no evidence of penicillin resistance. Hence, penicillin is the recommended course of treatment for syphilis, whereas doxycycline, tetracycline, ceftriaxone, and amoxicillin are viable alternative options. In recent years, efforts to discover a vaccine for syphilis have been reignited with better knowledge of the repertoire of T. pallidum outer membrane proteins (OMPs), which are the most probable syphilis vaccine candidates. However, research on therapeutic interventions and vaccine development for human subjects is limited due to practical and ethical considerations. Thus, the preclinical model is ideal for conducting research, and it plays an important role in clinical transformation. Different preclinical models have recently emerged, such as in vitro culture and mouse models, which will lay a solid foundation for clinical treatment and prevention of syphilis. This review aims to provide a comprehensive summary of the most recent syphilis tactics, including detection, drug resistance treatments, vaccine development, and preclinical models in clinical practice.

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CXCL8, CXCL9, and CXCL10 serum levels increase in syphilitic patients with seroresistance

Cited by 5 publications

References 24 publications

Serum Interleukin-26 is a Potential Biomarker for the Differential Diagnosis of Neurosyphilis and Syphilis at Other Stages

Serum Interleukin-26 is a Potential Biomarker for the Differential Diagnosis of Neurosyphilis and Syphilis at Other Stages

Can alpha‐linolenic acid be a modulator of “cytokine storm,” oxidative stress and immune response in SARS‐CoV‐2 infection?

Resurgence of syphilis: focusing on emerging clinical strategies and preclinical models

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