CXCL8 in thyroid disease: From basic notions to potential applications in clinical practice

Rotondi, Mario; Coperchini, Francesca; Chiovato, Luca

doi:10.1016/j.cytogfr.2013.08.001

Cited by 42 publications

(30 citation statements)

References 74 publications

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“…Since CXCL8 recruits leukocytes and promotes angiogenesis, its role in tumor invasion and metastatic spread appears to be reasonable. However, no association between CXCL8 expression of and tumor staging or patients' outcome was found, likely because of the poor aggressive behavior of PTC [23].…”

Section: Discussionmentioning

confidence: 87%

Effects of Chronic Lymphocytic Thyroiditis on the Clinicopathological Features of Papillary Thyroid Cancer

et al. 2018

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Background: The effects of chronic lymphocytic thyroiditis (CLT) on the presentation and outcome of papillary thyroid carcinoma (PTC) have long been a topic of controversy. Objective: To evaluate the effect of coexistent CLT on the clinicopathological features of PTC. Design: Retrospective study. Patients: All patients with PTC who had been followed by the 2 co-investigators (Juan Rivera and Richard J. Payne) between 2006 and 2011 were included. Results: CLT was present in 35% (166) of the included patients and was associated with a higher proportion of patients with TNM stage I (p = 0.027) and fewer patients with persistent disease (p = 0.014) in comparison with the PTC-only group. Analysis of the data based on age (<45 or >45 years) revealed that in the older group, the presence of CLT was associated with fewer patients with persistent disease (p = 0.03) and capsular invasion (p = 0.05). However, in patients <45 years of age, the presence of CLT was associated with more capsular invasion (p = 0.003) and extrathyroidal extension (p = 0.004) compared with the PTC-only group. Conclusions: CLT in patients with PTC was associated with lower-stage disease and less disease persistence in patients >45 years of age. In patients <45 years, the presence of CLT appeared to be associated with unfavorable pathological features.

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Section: Discussionmentioning

confidence: 87%

Effects of Chronic Lymphocytic Thyroiditis on the Clinicopathological Features of Papillary Thyroid Cancer

et al. 2018

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“…Several studies demonstrated that human normal and tumor thyroid cells secrete CXCL8 [5-10, 13, 14, 17]. However, the biological significance of CXCL8 and its role as a tumor-promoting chemokine in thyroid cancer was only recently demonstrated and not yet completely unveiled [4]. CXCL8 directly stimulates the proliferation of thyroid tumor cells via autocrine and paracrine mechanisms, which are mediated by its receptors, CXCR1 and CXCR2 being expressed on tumor cells [16].…”

Section: Discussionmentioning

confidence: 98%

“…TNF-a is produced for example by infiltrating immune cells and fibroblasts (the major players of the inflammatory response) and also by cancer cells themselves [14]. The presence of CXCL8 within the tumor microenvironment was recently identified to play relevant tumor-promoting effects [2][3][4]. Indeed, CXCL8 enhances the secretion of growth factors by tumor-associated macrophages, which in turn further increase the rate of tumor cell proliferation and also play a role in the angiogenic and metastatic potential of many solid cancers [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…The presence of CXCL8 within the tumor microenvironment was recently identified to play relevant tumor-promoting effects [2][3][4]. Indeed, CXCL8 enhances the secretion of growth factors by tumor-associated macrophages, which in turn further increase the rate of tumor cell proliferation and also play a role in the angiogenic and metastatic potential of many solid cancers [2][3][4]. For these reasons, the interest for further advances in the understanding of CXCL8 regulation as well as in CXCL8 targeting and/or inhibition has rapidly grown in recent years [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Normal human thyroid cells, BCPAP, and TPC-1 thyroid tumor cell lines display different profile in both basal and TNF-α-induced CXCL8 secretion

et al. 2015

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CXCL8 is secreted by both normal human thyrocytes (NHT) and thyroid cancer cell lines. CXCL8 displays several tumor-promoting effects and recent evidences indicate that its concentrations within the tumor microenvironment can impact the clinical course of the malignancy. Aim of this study was to compare the basal secretion of CXCL8 among NHT and thyroid cancer cell lines (TPC-1 and BCPAP), and to assess the specific cell response to TNF-α in terms of CXCL8 secretion. NHT primary cultures, TPC-1 and BCPAP cell lines were cultured with or without TNF-α (0, 0.1, 1, 10, and 100 ng/ml). CXCL8 levels were measured in the cell supernatants after 24 h. In basal condition, significant differences in the mean levels of CXCL8 were observed among the three cell types: NHT (110.5 ± 56.2 pg/ml), TPC1 (467.4 ± 43.2 pg/ml), and BCPAP (1731.8 ± 493.3 pg/ml), (F = 35.06; p < 0.0001). TNF-α significantly and in a dose-response manner induced CXCL8 secretion in NHT (F = 25.53; p < 0.00001), TPC-1 (F = 13.38; p < 0.0001), and BCPAP (F = 9.88; p < 0.001) cells. The magnitude of the TNF-α effect (fold-increase vs. basal level of CXCL8) differed significantly among the three cell types (F = 10.47; p < 0.0001). BCPAP were identified as the cells showing the highest basal secretion of CXCL8 and the less responsive to TNF-α. NHT, TPC-1, and BCPAP display significant differences in the secretion of both basal and TNF-α-induced CXCL8 secretion. These results indicate that the mechanisms regulating the secretion of CXCL8 differ in tumor cells harboring different genetic alterations suggesting that specific strategies aimed at inhibiting CXCL8 secretion will be required.

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“…38,39 Thyroid cells produce several CXC chemokines, including CXCL1, CXCL8/IL-8, CXCL9, CXCL10 and CXCL11, in basal conditions and/or under the influence of specific stimuli. 40,41 A wide variety of thyroid tumor cell lines derived from PTC and ATC release CXCL8/IL-8, in basal conditions as well as under inflammatory stimuli, such as IL-1 and TNF-a. 9,42 Exogenous induction of RET/PTC1 oncogene in primary normal human thyreocytes induced the expression of CCL2, CCL20 and CXCL8/IL-8 genes.…”

Section: Chemokinesmentioning

confidence: 99%

The immune network in thyroid cancer

2016

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The immune system plays critical roles in tumor prevention, but also in its initiation and progression. Tumors are subjected to immunosurveillance, but cancer cells generate an immunosuppressive microenvironment that favors their escape from immune-mediated elimination. During chronic inflammation, immune cells can contribute to the formation and progression of tumors by producing mitogenic, prosurvival, proangiogenic and lymphangiogenic factors. Thyroid cancer is the most frequent type of endocrine neoplasia and is the most rapidly increasing cancer in the US. In this review, we discuss recent findings on how different immune cells and mediators can contribute to thyroid cancer development and progression.

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CXCL8 in thyroid disease: From basic notions to potential applications in clinical practice

Cited by 42 publications

References 74 publications

Effects of Chronic Lymphocytic Thyroiditis on the Clinicopathological Features of Papillary Thyroid Cancer

Effects of Chronic Lymphocytic Thyroiditis on the Clinicopathological Features of Papillary Thyroid Cancer

Normal human thyroid cells, BCPAP, and TPC-1 thyroid tumor cell lines display different profile in both basal and TNF-α-induced CXCL8 secretion

The immune network in thyroid cancer

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