CXCR4/CXCR7/CXCL12-Axis in Follicular Thyroid Carcinoma

Werner, Thomas; Förster, Christina; Dizdar, Levent; Verde, Pablo Emilio; Raba, Katharina; Schott, M.; Knoefel, Wolfram Trudo; Krieg, Andreas

doi:10.7150/jca.23042

Cited by 24 publications

(15 citation statements)

References 61 publications

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“…Interestingly, CXCR4 expression was significantly greater in distant metastases as compared with the primary tumor. Again, CXCL12 induced cell growth, cell-cycle activation and EMT, while CXCR4 antagonists significantly reduced FTC invasiveness in vitro (Werner et al 2018).…”

Section: The Cxcr7/cxcr4/cxcl12 Axismentioning

confidence: 88%

Role of chemokine receptors in thyroid cancer and immunotherapy

Coperchini

Croce

Marinò

et al. 2019

Endocrine-Related Cancer

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Inflammation is currently regarded as an essential component of malignancies. It is now known that the tumor microenvironment may profoundly influence the biological behavior of cancer cells and ultimately the patient’s outcome. Chemokine and their receptor play a major role in determining the immune phenotype of the cells infiltrating the thyroid tumor microenvironment. Experimental evidence shows that both normal and cancer thyroid cells express specific chemokine receptors. The expression of at least some of these receptors exerts several biological effects, which influence the course of the disease. The present review article will take into account the role of the most studied chemokine receptors (CXCR1, CXCR2, CXCR3, CXCR4, CXCR7, DARC, CCR3, CCR6 and CCR7) in the context of thyroid cancer. This review will focus on current knowledge provided by in vitro and in vivo studies specifically performed on thyroid cancer including (i) expression of chemokine receptors in normal and cancer thyroid cells; (ii) role of chemokine receptors in affecting the biological behavior of thyroid tumors including the metastatic process; (iii) current knowledge about immunotherapies through targeting of chemokine receptors in thyroid cancer.

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Section: The Cxcr7/cxcr4/cxcl12 Axismentioning

confidence: 88%

Role of chemokine receptors in thyroid cancer and immunotherapy

Coperchini

Croce

Marinò

et al. 2019

Endocrine-Related Cancer

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“…Activation of the CXCL12-CXCR4 signaling axis promotes epithelial-mesenchymal transition (EMT) ( Sleightholm et al, 2017 ; Yang, Hu & Zhou, 2019 ). The biological roles of CXCL12 also were founded in THCA, in which CXCR4/CXCR7/CXCL12 axis offer new valuable insight into the oncogenesis of metastatic follicular thyroid carcinoma ( Werner et al, 2018 ). The amplification of MET proto-oncogene, receptor tyrosine kinase (MET) is confirmed as a resistance factor in gastric cancer cells ( Ebert et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Identifying hub genes of papillary thyroid carcinoma in the TCGA and GEO database using bioinformatics analysis

Wang

Zhang²,

Leng³

et al. 2020

PeerJ

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Background Thyroid carcinoma (THCA) is a common endocrine malignant tumor. Papillary carcinoma with low degree of malignancy and good prognosis is the most common. It can occur at any age, but it is more common in young adults. Although the mortality rate is decreased due to early diagnosis, the survival rate varies depending on the type of tumor. Therefore, the purpose of this study is to identify hub biomarkers and novel therapeutic targets for THCA. Methods The GSE3467, GSE3678, GSE33630 and GSE53157 were obtained from the GEO database, including 100 thyroid tumors and 64 normal tissues to obtain the intersection of differentially expressed genes, and a protein-protein interaction network was constructed to obtain the HUB gene. The corresponding overall survival information from The Cancer Genome Atlas Project-THCA was then included in this research. The signature mechanism was studied by analyzing the gene ontology and the Kyoto Encyclopedia of Genes and Genome database. Results In this research, we identified eight candidate genes (FN1, CCND1, CDH2, CXCL12, MET, IRS1, DCN and FMOD) from the network. Also, expression verification and survival analysis of these candidate genes based on the TCGA database indicate the robustness of the above results. Finally, our hospital samples validated the expression levels of these genes. Conclusion The research identified eight mRNA (four up–regulated and four down–regulated) which serve as signatures and could be a potential prognostic marker of THCA.

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“…At present, AMD3100 is successfully being used in the treatment of hematological malignancies ( Table 2 ) [ 148 , 149 ]. Indeed, results from observational studies encourage the use of AMD3100 against a broader spectrum of neoplasms, solid tumors included [ 230 , 231 , 232 ].…”

Section: Mmp-9 Inhibitorsmentioning

confidence: 99%

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

Barillari

2020

IJMS

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In industrialized countries, cancer is the second leading cause of death after cardiovascular disease. Most cancer patients die because of metastases, which consist of the self-transplantation of malignant cells in anatomical sites other than the one from where the tumor arose. Disseminated cancer cells retain the phenotypic features of the primary tumor, and display very poor differentiation indices and functional regulation. Upon arrival at the target organ, they replace preexisting, normal cells, thereby permanently compromising the patient’s health; the metastasis can, in turn, metastasize. The spread of cancer cells implies the degradation of the extracellular matrix by a variety of enzymes, among which the matrix metalloproteinase (MMP)-9 is particularly effective. This article reviews the available published literature concerning the important role that MMP-9 has in the metastatic process. Additionally, information is provided on therapeutic approaches aimed at counteracting, or even preventing, the development of metastasis via the use of MMP-9 antagonists.

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CXCR4/CXCR7/CXCL12-Axis in Follicular Thyroid Carcinoma

Cited by 24 publications

References 61 publications

Role of chemokine receptors in thyroid cancer and immunotherapy

Role of chemokine receptors in thyroid cancer and immunotherapy

Identifying hub genes of papillary thyroid carcinoma in the TCGA and GEO database using bioinformatics analysis

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

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