2024
DOI: 10.1186/s12964-024-01828-y
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CXCR4 regulates macrophage M1 polarization by altering glycolysis to promote prostate fibrosis

Yi Zhang,
Chen Zhang,
Rui Feng
et al.

Abstract: Background C-X-C receptor 4(CXCR4) is widely considered to be a highly conserved G protein-coupled receptor, widely involved in the pathophysiological processes in the human body, including fibrosis. However, its role in regulating macrophage-related inflammation in the fibrotic process of prostatitis has not been confirmed. Here, we aim to describe the role of CXCR4 in modulating macrophage M1 polarization through glycolysis in the development of prostatitis fibrosis. Methods … Show more

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