Cyanidin‐3‐glucoside protects against high glucose‐induced injury in human nucleus pulposus cells by regulating the Nrf2/HO‐1 signaling

Bai, Xiaoliang; Lian, Yong; Hu, Changqing; Yang, Shuai; Pei, Bo; Yao, Meicun; Zhu, Xiaojuan; Shang, Lin; Li, Zhihong

doi:10.1002/jat.4281

Cited by 11 publications

(6 citation statements)

References 30 publications

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“…5i). These outcomes may because of the transcription of antioxygenic proteins, such as heme oxygenase-1 (HO-1) as reported by previous studies 25,26 . Due to the proteome showed that the succinic dehydrogenase (SDH) A/B, which were less abundant in association with membrane in the hippocampus from hTau mice than that from Tau KO mice under hyperglycemia conditions (Extended Data Fig.…”

Section: Human Tau Restricted Oxidative Phosphorylation and Reduced R...mentioning

confidence: 80%

Human tau promotes Warburg effect-like glycolytic metabolism under acute hyperglycemia conditions through modulating the homeostasis of protein-membrane association

Yao,

Fu,

et al. 2024

Preprint

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SummaryThe neurofilaments formed by hyperphosphorylated tau is a hallmark of tau-related neurodegenerative disease, including Alzheimer’s disease, tau related FTDP-17, Pick’s disease, et al. However, the biological functions of tau and the physiological significance of its phosphorylation are still not fully understood. By using human tau (441 a.a.) transgenic (hTau) mice in which murine tau has been deleted simultaneously, murine tau knockout (Tau KO) mice and C57BL/6J (C57) mice, unexpectedly, we found that under acute hyperglycemia conditions, JNK but not previously reported GSK-3β mediated tau phosphorylation. Moreover, Akt, the upstream GSK-3β inhibitory kinase, was activated in a tau dependent manner. By comparing the membrane-associated proteome, we found that human tau influenced the homeostasis of protein-membrane association under acute hyperglycemia conditions. Of note, with respect to WT and Tau KO mice, the membrane-association of Krts, TFAM, TRAP1, mTOR et al, were strengthened by human tau. Whereas, the membrane-association of ribosomal proteins Rpls, proteasome proteins Psmds, and mitochondrial proteins, such as COXs, Ndufa1, Mtnt4, et al, were impeded by human tau. In vitro study showed that aerobic glycolysis was promoted in the presence of human tau, which maintained NAD+/NADH ratio. On the other hand, it restricted oxidative phosphorylation level, modulated the activity of SDH, and reduced ROS production upon challenging by high glucose. Furthermore, under acute high glucose conditions, the presence of human tau significantly augmented Akt activation, but inhibited 4EBP phosphorylation simultaneously, indicating that human tau is also involved in regulating the alternative activation of mTORC1/2. In summary, the current study revealed that human tau played an important role in regulating glycolytic metabolism under acute high hyperglycemia conditions, which is similar with the Warburg-effect, through influencing the homeostasis of protein-membrane association.

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Section: Human Tau Restricted Oxidative Phosphorylation and Reduced R...mentioning

confidence: 80%

Human tau promotes Warburg effect-like glycolytic metabolism under acute hyperglycemia conditions through modulating the homeostasis of protein-membrane association

Yao,

Fu,

et al. 2024

Preprint

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“…VC is known to be able to combine directly with hydrogen peroxide and its free radicals to perform an antioxidant role [ 43 ]; therefore, enhanced CAT activity is not required to degrade H 2 O 2 . Differentially, DAC may increase CAT transcription and expression by increasing Nrf2 expression [ 44 ], so DAC may improve CAT activity better than VC. But VC may still increase SOD and GSH-Px mRNA levels in mice [ 45 ] and can also positively regulate TRAIL expression in human breast cancer cells and activate Caspase [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Anthocyanins from Dioscorea alata L. on Antioxidant Properties of Perinatal Hainan Black Goats and Its Possible Mechanism in the Mammary Gland

Zhang

Shi

Yun

et al. 2022

Animals

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(1) Background: The mammary glands of the perinatal goats are susceptible to reactive oxygen species (ROS) leading to oxidative injury. Although Dioscorea alata L. is rich in anthocyanins with high safety and excellent free-radical-scavenging ability, the effect and mechanism of Dioscorea alata L. anthocyanins (DAC) on the antioxidant capacity of the black Hainan goat has been the subject of few studies to date; (2) Methods: For this reason, feeding experiments were performed by feeding experimental diets, and the pre-protective capacity of DAC on goat mammary epithelial cells was explored on the basis of the established model of H2O2 injury; (3) Results: As well as altering rumen fermentation parameters in perinatal female goats, dietary challenge also improves antioxidant capacity in their blood and milk. thereby enhancing children’s antioxidant capacity and increasing their resistance to oxidative stress. However, we also found that DAC pretreatment was capable of activating both Nrf2 and MAPK/JNK pathways, which results in enhanced antioxidase activity and elimination of ROS; (4) Conclusions: Together, these findings suggest that DAC may have a pre-protective role on perinatal Hainan black goats through the regulation of Nrf2 and MAPK/JNK pathways in GMEC.

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“…Besides, they also found that C3G could increase the proteoglycan and Col2 content and inhibit MMP3 and MMP13 expression in human disc cells. 76 …”

Section: Therapeutic Strategies By Targeting Nrf2mentioning

confidence: 99%

The Pivotal Role of Nrf2 Signal Axis in Intervertebral Disc Degeneration

Pan,

Hou,

Deng

et al. 2023

JIR

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Intervertebral disc degeneration (IDD) is considered as a dominant contributor to low back pain (LBP), causing severe pain, limited range of lumbar motion, physical dysfunction, and restriction of social activity. However, the specific pathological mechanisms underlying IDD remain elusive, and effective strategies to delay the pathogenesis of IDD are still unclear and limited. In recent years, some studies have found that nuclear factor erythroid 2-related factor 2 (Nrf2), an important antioxidant transcription factor, may play crucial roles in the pathogenesis and progression of age-related diseases including IDD. Nrf2 can maintain redox homeostasis and protecting nucleus pulposus (NP) cells against oxidative stress, inflammatory response, extracellular matrix (ECM) catabolism, cell senescence and cell death involving in the progression of IDD. In this review, we aim to systematically describe the vital roles and pathological mechanism of Nrf2 signaling axis in the pathogenesis of IDD, which may put forward potential therapeutic strategies for the prevention and treatment of IDD by targeting Nrf2.

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Cyanidin‐3‐glucoside protects against high glucose‐induced injury in human nucleus pulposus cells by regulating the Nrf2/HO‐1 signaling

Cited by 11 publications

References 30 publications

Human tau promotes Warburg effect-like glycolytic metabolism under acute hyperglycemia conditions through modulating the homeostasis of protein-membrane association

Human tau promotes Warburg effect-like glycolytic metabolism under acute hyperglycemia conditions through modulating the homeostasis of protein-membrane association

The Effect of Anthocyanins from Dioscorea alata L. on Antioxidant Properties of Perinatal Hainan Black Goats and Its Possible Mechanism in the Mammary Gland

The Pivotal Role of Nrf2 Signal Axis in Intervertebral Disc Degeneration

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