Cyanidin-3-O-glucoside from blueberry anthocyanin extracts protects ARPE-19 cells against high glucose damage via REDD1/GSK3β pathway

Li, Rui; Ye, Zhan; Xu, Yong-jiang; Liu, Yuanfa

doi:10.1016/j.fbio.2023.103322

Cited by 4 publications

(1 citation statement)

References 44 publications

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“…Cyanidin-3-glucoside (C3G), also called chrysanthemin, is one of the most widely distributed anthocyanins found in nature. Similar to BRAs, C3G showed protective effects in in vivo and in vitro models of DR but gained more attention for its relative stability and easier absorbance [ 106 , 107 , 108 ]. Molecular docking analysis revealed that C3G could combine well with 78-kDa glucose-regulated protein (GRP78), a major endoplasmic reticulum (ER) chaperone protein, hence regulating ER stress [ 105 , 109 ].…”

Section: Nutraceuticalsmentioning

confidence: 99%

Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems

Ye,

Fung,

Lam

et al. 2024

Nutrients

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Diabetic retinopathy (DR) is a major vision-threatening disease among the working-age population worldwide. Present therapeutic strategies such as intravitreal injection of anti-VEGF and laser photocoagulation mainly target proliferative DR. However, there is a need for early effective management in patients with early stage of DR before its progression into the more severe sight-threatening proliferative stage. Nutraceuticals, natural functional foods with few side effects, have been proposed to be beneficial in patients with DR. Over the decades, many studies, either in vitro or in vivo, have demonstrated the advantages of a number of nutraceuticals in DR with their antioxidative, anti-inflammatory, neuroprotective, or vasoprotective effects. However, only a few clinical trials have been conducted, and their outcomes varied. The low bioavailability and instability of many nutraceuticals have indeed hindered their utilization in clinical use. In this context, nanoparticle carriers have been developed to deliver nutraceuticals and to improve their bioavailability. Despite its preclinical nature, research of interventive nutraceuticals for DR may yield promising information in their clinical applications.

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Section: Nutraceuticalsmentioning

confidence: 99%

Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems

Ye,

Fung,

Lam

et al. 2024

Nutrients

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Deletion of the stress response protein REDD1 prevents sodium iodate-induced RPE damage and photoreceptor loss

Subrahmanian,

Yerlikaya,

Sunilkumar

et al. 2024

GeroScience

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Age-related macular degeneration (AMD) is a leading cause of blindness in elderly populations, yet the molecular events that initiate the early retinal defects that lead to visual function deficits remain poorly understood. The studies here explored a role for the stress response protein Regulated in Development and DNA damage response 1 (REDD1) in the development of retinal pathology by using the oxidant stressor sodium iodate (NaIO3) to model dry AMD in mice. REDD1 protein abundance was increased in the retinal pigmented epithelium (RPE) and retina of mice administered NaIO3. In wild-type REDD1+/+ mice, reactive oxygen species (ROS) levels were robustly increased in the outer retinal layers 1 day after NaIO3 administration, with focal areas of increased ROS seen throughout the outer retina after 7 days. In contrast with REDD1+/+ mice, ROS levels were blunted in REDD1−/− mice after NaIO3 administration. REDD1 was also required for upregulated expression of pro-inflammatory factors in the RPE/retina and immune cell activation in the outer retina following NaIO3 administration. In REDD1+/+ mice, NaIO3 reduced RPE65 and rhodopsin levels in the RPE and photoreceptor layers, respectively. Unlike REDD1+/+ mice, REDD1−/− mice did not exhibit disrupted RPE integrity, retinal degeneration, or photoreceptor thinning. Overall, REDD1 deletion was sufficient to prevent retinal oxidative stress, RPE damage, immune cell activation, and photoreceptor loss in response to NaIO3. The findings support a potential role for REDD1 in the development of retinal complications in the context of dry AMD.

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Protective effect of Cyanidin-3-O-glucoside from blueberry anthocyanin extracts against hyperglycemia-induced outer BRB damage by suppressing REDD1-mediated VEGFA upregulation

Li,

Du,

et al. 2024

Food Bioscience

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Cyanidin-3-O-glucoside from blueberry anthocyanin extracts protects ARPE-19 cells against high glucose damage via REDD1/GSK3β pathway

Cited by 4 publications

References 44 publications

Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems

Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems

Deletion of the stress response protein REDD1 prevents sodium iodate-induced RPE damage and photoreceptor loss

Protective effect of Cyanidin-3-O-glucoside from blueberry anthocyanin extracts against hyperglycemia-induced outer BRB damage by suppressing REDD1-mediated VEGFA upregulation

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