Cyanidin-3-O-Glucoside Supplement Improves Sperm Quality and Spermatogenesis in a Mice Model of Ulcerative Colitis

Abstract

Impaired fertility and low sperm quality are the global health problem with high attention. It has been noted that inflammation may impact fertility by affecting testicular spermatogenesis. Cyanidin-3-O-glucoside is a natural functional pigment with various health benefits. Nevertheless, studies on the mechanism by which C3G protects male reproduction in mice with ulcerative colitis remain scarce. The purpose of this study is to illustrate the potential mechanism of C3G for improving impaired fertility caused by colitis. A DSS-induced colitis model was applied to assess the effects of sperm quality with colitis and the health benefit role of C3G. Results indicated that C3G-treated mice exhibited higher body weight, longer colon length, less crypt damage and focal inflammation infiltration. Being consistent with that, low sperm count, low testis weight, high inflammation levels and abnormal thickness of seminiferous epithelium also observed in the DSS group were significantly recovered upon C3G treatment. These findings suggested that colitis has a close link to impaired fertility. Further analysis found that C3G could significantly suppress the inflammatory mediators in serum. Results conjointly indicated that C3G might improve the impaired fertility of mice with colitis by inhibiting inflammatory cytokines through the blood–testis barrier. C3G could be a promising daily supplement for ameliorating impaired fertility caused by colitis.

Efficacy and mechanism of lipoic acid in the treatment of reproductive injury caused by perfluorooctanoic acid

“…LA relieves spermatogenesis disorder caused by PFOA. Sperm count is an important indicator of reproductive toxicology, which accurately reflects the degree of reproductive damage to animals caused by toxicants (15,16). The sperm counts of rats were reduced after PFOA intoxication compared with the counts of rats in control and LA groups.…”

Interaction between a Commercial Mannoprotein and Cyanidin-3-O-glucoside-4-vinylphenol and Its Stability and Antioxidative Properties as a Novel Functional Pigment

“…Anthocyanins like C3G and vitisin A always exhibited good solubility under physiological conditions, which could be considered in many biological studies. − C3GVP differs from these anthocyanins in its additional E-ring from p -coumaric acid, which is insoluble in water. So, p -coumaric acid may likely endow C3GVP with the property of easy intermolecular polymerization at the E-ring, inducing it to aggregate and precipitate in complex environments.…”

The Role of Anthocyanins in Alleviating Intestinal Diseases: A Mini Review

“…Colorful fruits, vegetables, flowers, and grains contain water-soluble pigments known as anthocyanins, which have shown bioactive properties in a number of ways. − As dietary supplements, anthocyanins provide a wide range of health benefits, for example, antioxidant, antimicrobial, anti-inflammatory, and neuroprotective. − The retrieval has already found that with the increasing number of publications, the renewed public interest of anthocyanins research is continuing, particularly in intestinal diseases. ,, …”