Cyanidin 3-O-β-D-glucoside isolated from skin of black Glycine max and other anthocyanins isolated from skin of red grape induce apoptosis in human lymphoid leukemia Molt 4B cells

Cyanidin 3-Glucoside and Peonidin 3-Glucoside Inhibit Tumor Cell Growth and Induce Apoptosis In Vitro and Suppress Tumor Growth In Vivo

“…Furthermore, there is an increased focus on providing a scientific basis to use these agents in the prevention strategy for people with a high risk for cancer. In this regard, extensive investigations with anthocyanins have shown promising results against different cancers, including human leukemia (HL60 and Molt 4B), liver cancer (HepG2), and colon cancer (HCT116) in vitro (23)(24)(25)(26). In the present study, we first provided evidence to prove the potential of cyanidin 3-glucoside Vol.…”

Grape extracts suppress the formation of preneoplastic foci and activity of fatty acid synthase in rat liver

“…Matito et al (2003) reported that polyphenolic fraction of grapes seemed to have antiproliferative effect in mouse hepatoma Hepa-1c1c7 cells, and the fraction with the highest degree of polymerization and galloylation showed the most induction of apoptosis and effectiveness on the cell cycle. Some anthocyanins from skin of red grape also inhibited human lymphoid leukemia Molt 4B cell growth, which could be induced by apoptosis (Katsuzaki et al, 2003). In addition, the cancer preventive effect of grape seed extract was examined on the human prostate carcinoma DU145 cells possi-bly via apoptotic death (Agarwal et al, 2002).…”

“…Resveratrol or polyphenolic extracts from grape have been reported to alter the amount of nitric oxide by modification of nitric oxide synthase (Flesch et al, 1998). Besides, polyphenolic compounds from grape increased the expression of p53 and p21, inhibited the cell proliferation (Hsieh et al, 1999), induced apoptosis in tumor cell (Agarwal et al, 2002;Katsuzaki et al, 2003;Matito et al, 2003), and acted as protein kinase C inhibitor (Stewart et al, 1999). All of them could be possible mechanisms of the Grape extracts suppress the form ation of preneoplastic foci and activity of fatty acid synthase in rat liver cancer preventive effect of grapes.…”

Black Raspberry Components Inhibit Proliferation, Induce Apoptosis, and Modulate Gene Expression in Rat Esophageal Epithelial Cells

“…Cyanidin and delphinidin were shown to be potent inhibitors of epidermal growth factor receptor (EGFR) resulting in a significant decrease in the proliferation of A431 human vulva carcinoma cells which over express EGFR (21). In addition, cyanidin reduced the growth of human colon cancer cell lines HT29 and HCT116 and, cyanidin 3- O -beta-D glucoside induced apoptosis and inhibited growth of human lymphoid leukemia Molt 4B cells (22, 23). …”