Cyanidin 3-O-β-d-glucoside-rich blackberries modulate hepatic gene expression, and anti-obesity effects in ovariectomized rats

Kaume, Lydia; Gilbert, William; Brownmiller, Cindi; Howard, Luke R.; Devareddy, Latha

doi:10.1016/j.jff.2012.02.008

Cited by 57 publications

(34 citation statements)

References 46 publications

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“…The present study showed that both HE and EE of T. foenumgraecum seed are able to improve metabolic status and decrease level of these cytokines in ovariectomized rats. Ovariectomy is a standard experimental model of menopause in rodent to investigate pharmacological management of postmenopausal symptoms (11,12,24,25). In our study, in agreement with previous reports, ovariectomy led to increased body weight gain (25,26).…”

Section: Discussionsupporting

confidence: 92%

“…Therefore, development of new agents with anti-inflammatory action and lesser side effects for management of menopause remains an attractive subject. It has been reported that a number of medicinal plants may be useful for preventing or treating some menopausal related complications such as insulin resistance, dyslipidemia, hepatic steatosis, weight gain, inflammation, and loss of bone mass (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause

Abedinzade¹,

Nasri²,

Omodi³

et al. 2015

Iran Red Crescent Med J

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Background: Several experimental and clinical studies support beneficial effects of Trigonella foenum-graecum (fenugreek) in the management of metabolic diseases and inflammatory disorders. Objectives: The purpose of this study was to examine the effect of T. foenum-graecum seed extract in reducing the metabolic and inflammatory alternations associated with menopause. Materials and Methods: In this experimental study, 49 rats were divided into seven groups: (I) sham-control, (II) ovariectomized-control, (III and IV) ovariectomized treated with 50 and 150 mg/kg of T. foenum-graecum seed ethanolic extract, (V and VI) ovariectomized treated with 50 and 150 mg/kg of T. foenum-graecum hexanic extract, (VII) ovariectomized-positive control treated with 10 µg/kg of estradiol. The extracts were injected intraperitoneally one day after ovariectomy and the treatments were lasted for 42 days. Results: Fasting blood glucose and body weight gain increased significantly in the ovariectomized-control group compared with that in the sham animals (P < 0.05). Administration of estradiol and T. foenum-graecum (50 and 150 mg/dL of hexanic extract and 150 mg/kg of ethanolic extract) significantly diminished the increase in glucose and body weight (P < 0.05). The serum level of interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in the ovariectomized control group was significantly higher than those in the sham animals (P < 0.05). Both hexanic and ethanolic extracts as well as estradiol were able to decrease level of these cytokines in the serum of ovariectomized rats (P < 0.05). Conclusions:The results of the present study show that administration of T. foenum-graecum corrects metabolic and inflammatory alterations associated with ovariectomy and has a potential for the management of menopause.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause

Abedinzade¹,

Nasri²,

Omodi³

et al. 2015

Iran Red Crescent Med J

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“…30- 32 The fruit pulp also includes cyanidin 3-glucoside, cyanidin 3-rutinoside, cyanidin 3-xyloside, cyanidin 3-malonylglucoside, cyanidin 3-dioxalylglucoside, quercetin 3-rutinoside, quercetin 3-galactoside, quercetin 3-glucoside, quercetin 3-glucuronide, quercetin 3-O-[600-(3-hydroxy-3-methylglutaroyl)]-β-galactoside, quercetin 3-glucosylpentoside, quercetin 3-oxalylpentoside, quercetin 3-rhamnoside, quercetin, lambertianin C isomer, sanguiin H-6 lambertianin A and galloyl-bis-HHDP glucose isomer. 28, 33 The seeds of Jamun have been reported to include 7-hydroxycalamenene, methyl-β-orsellinate, β-sitosterol, and oleanolic acid, and 3-hydroxy androstane [16,17-C](6′methyl, 2′-1-hydroxyisopropene-1-yl) 4,5,6 H pyran. 34 The methanol extract of Jamun seeds showed the presence of 34 chemicals, principle among them being 5,10-dichloro-5,10-dimethyltricyclo[7.1.0.0(4,6)]decane, tetradecanoic acid, α-caryophyllene, 1,10-decandiol, β caryophyllene, bicyclo(4.4.O)decane, octadienol, cadinene, 4-dodecen-1-ol acetate, 2-furancarboxaldehyde 5-(hydroxymethyl) and oxirane 2,3-dimethyl.…”

Section: Active Componentsmentioning

confidence: 99%

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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Plants have been employed as medicine since time immemorial, and there has been a recent resurgence in the use of plants as medicines due to their little or no toxicity at the doses used for treatment of different ailments. This review discusses in detail the phytochemical and pharmacological activities of Jamun (Syzygium cumini), a tree belonging to family Myrtaceae, which has been credited with several medicinal properties in the traditional system of medicine, the Ayurveda. The different properties attributed to Jamun are sweet, sour, astringent, acrid, refrigerant, carminative, diuretic, and digestive. Research and practical use in traditional medicinal systems have found Jamun to be effective in treating leucorrhoea, gastric disorders, fever, diabetes, piles, stomachache, wounds, and dental, digestive and skin disorders. Some compounds in Jamun have antioxidant, antimicrobial, antiallergic, antidiabetic, antihyperlipidemic, anticancer, gastroprotective, hepatoprotective, cardioprotective and radioprotective activity. Finally, Jamun has been found to contain phytochemicals including anthroquinones, alkaloids, catechins, flavonoids, glycosides, steroids, phenols, tannins, saponins and cardiac glycosides. The diverse activities of Jamun may be due to its abilities to scavenge free radicals, increase antioxidant status of cells by increasing glutathione, glutathione peroxidase, catalase and/or superoxide dismutase, and to attenuate lipid peroxidation. In addition, it also suppresses the transcription of peroxisome proliferator-activated receptor, Nuclear factor kappa B, cyclooxygenase, inducible nitric oxide synthase, tumor necrosis factor alpha and other proinflammatory cytokines, accompanied by the up-regulation of nuclear factor erythroid 2-related factor 2 transcription, which is involved in regulating the antioxidant status of the cells.

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“…In addition, anthocyanins and their aglycones play a role in inducing insulin secretion [18]. They also reveal anti-obesity activity by improving adipocyte function [19,20]. The other important group of bioactive Rubus compounds are ellagitannins and their derivative ellagic acid that occur not only in the fruit pulp but also in seeds, which are the best source of these hydrolysable tannins.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant properties of fruits of raspberry and blackberry grown in central Europe

et al. 2015

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Fruits of several, mainly Polish cultivars of floricane-and primocane-fruiting red raspberry (Rubus idaeus), black raspberry (Rubus occidentalis) and blackberry (Rubus fruticosus), grown in central Europe during two successive vegetation periods, were investigated. The content of phenolic compounds, including anthocyanins, as well as antioxidant properties of fruit extracts were analysed. A number of methods were employed: ferric ion reducing antioxidant power (FRAP), cupric ion reducing antioxidant capacity (CUPRAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity involving both colorimetric and EPR spectrometric measurements. From among all the tested fruits black raspberries had the largest antioxidant capacity as verified by all methods used in this study. These berries were also the most abundant in phenolic and anthocyanin compounds. Blackberries were characterised by larger antioxidant capacity than red raspberry fruits which were accompanied by higher content of total phenolics and anthocyanins. Berries of primocane-fruiting cultivars, often used for intensive agricultural production, generally did not differ in the total phenolic and anthocyanin content as well as in the antioxidant capacity as compared to the traditional, floricane-fruiting ones. The research contributes to deep characterisation of central European berry fruits which due to their high content and large diversity of health-beneficial compounds are classified as natural functional food.

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Cyanidin 3-O-β-d-glucoside-rich blackberries modulate hepatic gene expression, and anti-obesity effects in ovariectomized rats

Cited by 57 publications

References 46 publications

Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause

Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Antioxidant properties of fruits of raspberry and blackberry grown in central Europe

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