Cyano-Phycocyanin: Mechanisms of Action on Human Skin and Future Perspectives in Medicine

Dranseikienė, Daiva; Balčiūnaitė-Murzienė, Gabrielė; Karosienė, Jūratė; Morudov, Dmitrij; Juodžiukynienė, Nomeda; Hudz, Nataliia; Gerbutavičienė, Rima Jūratė; Savickienė, Nijolė

doi:10.3390/plants11091249

Cited by 16 publications

(16 citation statements)

References 64 publications

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“…Arthrospira platensis BEA_IDA_0074B was selected because of its unique ability to produce large amounts of cyano-phycocyanin compared with other strains (unpublished data). Some reported skin beneficial properties of cyano-phycocyanin are antimicrobial activity against Cutibacterium acnes ( 35 ) and anti-inflammatory effects ( 36 ).…”

Section: Methodsmentioning

confidence: 99%

A Randomized Clinical Trial to Evaluate the Efficacy of an Oral Probiotic in Acne Vulgaris

Eguren,

Navarro-Blasco,

Corral-Forteza

et al. 2024

Acta Derm Venereol

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The relevance of the gut microbiota in some skin inflammatory diseases, including acne vulgaris, has been emphasized. Probiotics could play a role in the modulation of the microbiota, improving the clinical course of this disease. A 12-week randomized, double-blind, placebo-controlled, clinical trial with patients aged 12 to 30 years with acne vulgaris was conducted. The study product was a capsule composed of the probiotic Lacticaseibacillus rhamnosus (CECT 30031) and the cyanobacterium Arthrospira platensis (BEA_IDA_0074B). Patients with improvement in the Acne Global Severity Scale were 10/34 (29.41%) in the placebo group compared with 20/40 (50%) in the probiotic group (p = 0.03). A significant reduction (p = 0.03) in the number of non-inflammatory acne lesions was observed in the probiotic group (–18.60 [–24.38 to –12.82]) vs the placebo group (–10.54 [–17.43 to –3.66]). Regarding the number of total lesions, a reduction almost reaching statistical significance (p = 0.06) was observed in the probiotic group (–27.94 [–36.35 to –19.53]) compared with the placebo group (–18.31 [–28.21 to –8.41]). In addition, patients with improvement attending the Global Acne Grading System were 7/34 (20.58%) in the placebo group vs 17/40 (42.50%) in the probiotic group (p = 0.02). The number of adverse events was similar in both groups. The probiotic used in this study was effective and well tolerated, and it should be considered for acne vulgaris patients.

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Section: Methodsmentioning

confidence: 99%

A Randomized Clinical Trial to Evaluate the Efficacy of an Oral Probiotic in Acne Vulgaris

Eguren,

Navarro-Blasco,

Corral-Forteza

et al. 2024

Acta Derm Venereol

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“…Cancer is a pathological condition characterized by uncontrolled growth and division of cells that can invade normal tissues and spread throughout the body [114]. The role of phycocyanin in cancer has been demonstrated by its ability to block tumor cell proliferation, inhibit the cell cycle, and induce apoptosis and autophagy of these cells [115].…”

Section: Anti-oxidativementioning

confidence: 99%

Exploring the Benefits of Phycocyanin: From Spirulina Cultivation to Its Widespread Applications

Fernandes¹,

Campos²,

Serra³

et al. 2023

Pharmaceuticals

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Large-scale production of microalgae and their bioactive compounds has steadily increased in response to global demand for natural compounds. Spirulina, in particular, has been used due to its high nutritional value, especially its high protein content. Promising biological functions have been associated with Spirulina extracts, mainly related to its high value added blue pigment, phycocyanin. Phycocyanin is used in several industries such as food, cosmetics, and pharmaceuticals, which increases its market value. Due to the worldwide interest and the need to replace synthetic compounds with natural ones, efforts have been made to optimize large-scale production processes and maintain phycocyanin stability, which is a highly unstable protein. The aim of this review is to update the scientific knowledge on phycocyanin applications and to describe the reported production, extraction, and purification methods, including the main physical and chemical parameters that may affect the purity, recovery, and stability of phycocyanin. By implementing different techniques such as complete cell disruption, extraction at temperatures below 45 °C and a pH of 5.5–6.0, purification through ammonium sulfate, and filtration and chromatography, both the purity and stability of phycocyanin have been significantly improved. Moreover, the use of saccharides, crosslinkers, or natural polymers as preservatives has contributed to the increased market value of phycocyanin.

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“…Additionally, cyanobacterial biomass can be transformed into various high-value products, including biofuels, cosmetics, foods, nutraceuticals, and pharmaceutical compounds [ 20 ]. A. platensis is one of the most important cyanobacteria genera and is well known for being a high source of protein (up to 50–70% of its cell mass) and bioactive ingredients such as vitamins, β-carotene, micro- and macro-elements, and polyunsaturated fatty acids [ 21 , 22 ]. Phycocyanin (PC) is a mainly water-soluble pigment protein (8–13% of dry biomass) that is found in cyanobacteria, particularly in A. platensis [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Melanin Production by Streptomyces antibioticus NRRL B-1701 Using Arthrospira (Spirulina) platensis Residues Hydrolysates as Low-Cost L-tyrosine Supplement

Kraseasintra

Sensupa

Mahanil

et al. 2023

BioTech

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Melanin is a functional pigment that is used in various products. It can be produced by Streptomyces antibioticus NRRL B-1701 when supplemented with L-tyrosine. Arthrospira (Spirulina) platensis is a cyanobacterium with high protein content, including the protein phycocyanin (PC). During PC’s extraction, biomass residues are generated, and these residues still contain various amino acids, especially L-tyrosine, which can be used as a low-cost supplement for melanin production. Thus, this study employed a hydrolysate of A. platensis biomass residue for L-tyrosine substitution. The effects of two drying methods, namely, lyophilization and dying via a hot air oven, on the proximate composition and content of L-tyrosine in the biomass residue were evaluated. The highest L-tyrosine (0.268 g L-tyrosine/100 g dried biomass) concentration was obtained from a hot-air-oven-dried biomass residue hydrolysate (HAO-DBRH). The HAO-DBRH was then used as a low-cost L-tyrosine supplement for maximizing melanin production, which was optimized by the response surface methodology (RSM) through central composite design (CCD). Using the RSM–CCD, the maximum level of melanin production achieved was 0.24 g/L, which is approximately four times higher than it was before optimization. This result suggests that A. platensis residue hydrolysate could be an economically feasible and low-cost alternative source of L-tyrosine for the production of melanin.

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Cyano-Phycocyanin: Mechanisms of Action on Human Skin and Future Perspectives in Medicine

Cited by 16 publications

References 64 publications

A Randomized Clinical Trial to Evaluate the Efficacy of an Oral Probiotic in Acne Vulgaris

A Randomized Clinical Trial to Evaluate the Efficacy of an Oral Probiotic in Acne Vulgaris

Exploring the Benefits of Phycocyanin: From Spirulina Cultivation to Its Widespread Applications

Optimization of Melanin Production by Streptomyces antibioticus NRRL B-1701 Using Arthrospira (Spirulina) platensis Residues Hydrolysates as Low-Cost L-tyrosine Supplement

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