Cyanoacrylate glue as part of a new bundle to decrease neonatal PICC-related complications

Piersigilli, Fiammetta; Iacona, Giulia; Yazami, Sarah; Carkeek, Katherine; Hocq, Catheline; Auriti, Cinzia; Danhaive, Olivier

doi:10.1007/s00431-023-05253-0

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…On the other hand, properly securing a PICC is also vitally important, as PICCs in neonates are prone to dislodgement, thus leading to mechanical complications. Recently, there has been a considerable amount of research into using a drop of cyanoacrylate glue at the PICC insertion point [65]. As the glue is transparent, the insertion point remains visible at all times.…”

Section: Future Research Into Reducing Complicationsmentioning

confidence: 99%

“…As the glue is transparent, the insertion point remains visible at all times. In one study, by using glue, they were able to reduce the rate of mechanical complications with no adverse skin reactions [65]. In addition, there is a randomised controlled trial in progress, looking at the use of cyanoacrylate glue for securing UVCs [58].…”

Section: Future Research Into Reducing Complicationsmentioning

confidence: 99%

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Central Lines and Their Complications in Neonates: A Case Report and Literature Review

Perme

2023

Children

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Central lines are essential devices in NICUs, used primarily in preterm neonates and critically ill term neonates. They are typically divided into non-tunnelled, tunnelled and totally implanted. In light of the increasing use of central lines in the NICU setting, monitoring of the risk factors associated with complications has to be an important part of neonatal care quality management. Presented here is a case of a preterm neonate with cardiac tamponade caused by UVC tip migration. Among complications of central lines are CLABSI, with an incidence of 3 to 21 per 1000 catheter days, and portal vein thrombosis, which is common but probably under-recognised, whereas other mechanical complications such as pericardial and pleural effusions are rare, with an incidence of less than 1%. Complications can cause injury to the neonates, as well as increase the costs of health services because of increases in the length of stay in the NICU. It is recommended that the catheter tip location is confirmed either by X-ray or ultrasonography. In order to minimise the risk of CLABSI, the use of bundles is recommended. Certain recommendations need to be followed when using different types of catheters. Future research is aimed at novel ways of central line securement to minimise mechanical complications and the use of antimicrobial catheters to reduce the rate of CLABSI.

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Section: Future Research Into Reducing Complicationsmentioning

confidence: 99%

Section: Future Research Into Reducing Complicationsmentioning

confidence: 99%

Central Lines and Their Complications in Neonates: A Case Report and Literature Review

Perme

2023

Children

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Use of tissue adhesive for neonatal intravenous access devices: A scoping review

de Souza,

Takashima,

Silva

et al. 2024

Eur J Pediatr

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Neonates often require vascular access devices for medication or fluid therapy, but a third of devices fail before treatment completion or end with a complication. For adults and children, securing these devices with tissue adhesive (TA) increases the dwell and reduces complications. However, there is a lack of evidence for the neonatal population. This scoping review aimed to assess the evidence of TA for vascular access devices in neonates. The Arksey and O’Malley’s (2005) framework was used. The inclusion criteria covered studies published from 2007 (when TA was first reported for use in vascular access devices) to June 2024, available in English, Portuguese, and Spanish, across six databases. Two independent reviewers assessed the studies using Covidence software, with a third reviewer resolving conflicts. Quality assessment was performed using the Mixed Methods Appraisal Tool. From 981 identified studies, 12 were included. Most studies (n = 5, 41.7%) enrolled between 100 and 500 neonates with vascular access devices. Publications originated from four regions and were observational studies (n = 6, 50%), quasi-experimental (n = 3, 25%), and case series (n = 2, 16.7%) with one randomized controlled trial (8.3%) focusing on umbilical venous catheters (UVC). The most common TA composition used was a combination of n-butyl- and 2-octyl- cyanoacrylate (n = 4, 33.3%). The amount of TA applied varied across studies, and often TA was part of a bundle (n = 7, 58.3%). Most studies applied TA to central venous access devices (n = 10, 83.3%) and 2 (16.7%) in peripheral devices. Although there was variation in device failure, the studies generally indicated a reduction in complications such as dislodgment (central catheter: 11.3% [peripherally inserted central catheter {PICC}] to 24.6% [UVC] in non-TA group vs 0.7% [PICC] to 7.7% [UVC] in TA group), device-associated bloodstream infections (central: 7.7% [UVC] and incidence of 2.76/1000 catheter days [PICC] in non-TA group vs 3.1% [UVC] and incidence of 0.99/1000 catheter day [PICC] in TA group), and phlebitis (13% in non-TA group vs 3% in TA-group), as well as increased dwell time in peripheral catheters. Most studies included both term and preterm neonates but did not differentiate between them in their analyses. Skin assessment, life of first dressing, and follow-up of catheters and patients were not reported in most studies. Conclusion: TA may reduce complications in vascular access devices, but the evidence in neonates is limited and varied. Many studies include TA as part of bundle, making it difficult to isolate its effects. Additionally, the current evidence lacks robustness due to the design limitations of the studies. Future research should focus on randomized controlled trials to evaluate TA’s effectiveness and safety in preventing device failures and complications in neonates, considering different subgroups, to ensure the safety of TA in these nuanced populations. What is Known:• Research in adults and pediatrics provides evidence supporting the use of tissue adhesive (TA) for vascular access devices, showing a positive impact in reducing failures and complications.• The use of TA in neonates needs to be carefully considered due to their unique characteristics.What is New:• There is a gap in the literature on the use of TA for securing vascular access devices in neonates, particularly regarding its safety and effectiveness in preventing failures and complications.• Further studies are needed to provide robust evidence verifying the effectiveness and safety of TA in this population.

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Zentralvenöse Katheter bei Neugeborenen mit Klebstoff sichern

2024

Neonatologie Scan

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Cyanoacrylate glue as part of a new bundle to decrease neonatal PICC-related complications

Cited by 4 publications

References 24 publications

Central Lines and Their Complications in Neonates: A Case Report and Literature Review

Central Lines and Their Complications in Neonates: A Case Report and Literature Review

Use of tissue adhesive for neonatal intravenous access devices: A scoping review

Zentralvenöse Katheter bei Neugeborenen mit Klebstoff sichern

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