Cyanoacrylate glue dressing for hypospadias surgery

Hosseini, Seyed Mohammad; Rasekhi, Alireza; Zarenezhad, Mohammad; Hedjazi, Arya

doi:10.4103/1947-2714.98593

Cited by 16 publications

(4 citation statements)

References 10 publications

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“…Glubran Tiss2® is a two-component skin adhesive, based on NBCA (n-butyl 2 cyanoacrylate) and OCA (2-octyl cyanoacrylate). It is used in many clinical centres in Italy as a sealant of the PICC exit site, mainly because of its haemostatic effect ( 13 ), but also because it creates an efficient antiseptic barrier against the most diffused infective or pathogenic agents coming from the surrounding skin ( 14 ). The blend of the two monomers (NBCA+OCA) provides a high tensile strength and improves the elasticity ( 13 ) of the glue.…”

Section: Methodsmentioning

confidence: 99%

Experimental study on the chemico-physical interaction between a two-component cyanoacrylate glue and the material of PICCs

et al. 2018

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Introduction:The use of cyanoacrylate glue as sealant on the exit site of peripherally inserted central catheters (PICCs) may offer some important clinical advantages. However, concerns exist about the potential interaction between cyanoacrylate and the material of the catheter itself. The aim of this study was to investigate the possibility of damage to the catheter secondary to a long-term contact with a two-component skin glue (N-butyl + octyl cyanoacrylate).Methods:Twelve PICCs of different brands and types were selected (11 made of polyurethane and one made of silicon). PICCs were glued onto artificial skin pads, slightly wetted with Earle solution. The pads were kept in an egg incubator at 34°C and 60% humidity, for up to twelve weeks. Possible signs of degradation were monitored by surface analyses and mechanical tests. Scanning electron microscopy observations, surface roughness measurements, pressure strength and uniaxial tests were performed.Results:Samples were analyzed after 4, 8 and 12 weeks of contact with the glue. No chemical reaction between the glue and the material of the catheters was evident. The mechanical strength of PICCs was consistently within the ranges of ISO standards. An expected increase in the stiffness of the samples covered with glue was observed in uniaxial tests. The silicon catheter was weaker than the polyurethane catheters and was damaged while trying to remove it from the pad for tests.Conclusions:The long-term use of N-butyl + octyl cyanoacrylate glue on polyurethane PICCs is not expected to be associated to any damage to the catheter.

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Section: Methodsmentioning

confidence: 99%

Experimental study on the chemico-physical interaction between a two-component cyanoacrylate glue and the material of PICCs

et al. 2018

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“…We demonstrated that UCF closure was achieved in 60% of our adhesive-treated UCF patients and in 68% of those treated surgically. Although the difference between groups in the successful UCF closure rate was not statistically significant, these results indicate clearly that the procedure should be included in the postoperative management of UCF and, as suggested by Lapointe et al [ 18 ], Prestipino et al [ 33 ], Tan et al [ 34 ] and Hosseini et al [ 35 ], should be regarded as an alternative to surgery for preventing or treating UCF. These observations support the results of simpler studies, such as those reported by Tsur et al [ 36 ] and Castañón García-Aliz et al [ 37 ].…”

Section: Discussionmentioning

confidence: 70%

“…The study found UCF recurrence in only four (11%) of the patients. Based on the waterproofing and moisture-resistance properties of the cyanoacrylate adhesives, Hosseini et al [ 35 ] undertook a case–control study in 61 children with a mean age of 13.5 months who underwent HSR using different techniques. Patients were divided into two groups: 41 children in whom conventional dressings were placed on the surgical site (control group) against 20 children in whom the suture lines were reinforced with NBCA+OCA (study group).…”

Section: Discussionmentioning

confidence: 99%

2-octyl cyanoacrylate versus reintervention for closure of urethrocutaneous fistulae after urethroplasty for hypospadias: a randomized controlled trial

et al. 2014

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BackgroundUrethrocutaneous fistulae (UCFs) represent one of the most frequent causes of morbidity after urethroplasty. Hypospadias can be repaired using different surgical techniques, but—regardless of technique—the incidence of UCF ranges between 10% and 40%. Surgical repair of UCF remains the treatment of choice, even if some patients need further surgery because of recurrences. Cyanoacrylates have been used as skin suture substitutes, and some evidence suggests a beneficial effect when these adhesives are used as an adjuvant in the management of UCF. Here we describe the results of management of UCF using 2-octyl cyanoacrylate (OCA) compared with surgical repair.MethodsA randomized clinical trial conducted from January 2008 to December 2012 included 42 children with UCF complications after urethroplasty for hypospadias. Twenty-one children were assigned to receive OCA as ambulatory patients and 21 were treated surgically. The main outcome variable was closure of the UCF. The estimated costs of both treatments were also calculated, as were absolute risk reduction (ARR), relative risk reduction (RRR) and number needed to treat (NNT) to prevent a surgical intervention.ResultsThe mean numbers of UCF were 1.3 in the OCA group (n = 28) and 1.1 in the surgical group (n = 25) with no statistically significant difference. The external orifices measured were 2.96 ± 1.0 mm and 3.8 ± 0.89 mm, respectively (NS). Sixty per cent of the UCFs treated with cyanoacrylate were completely closed and 68% of the surgical group healed completely (NS). More than one reoperation to improve complications was needed in the surgical group (3.5 ± 1.2). The clinical significance of the therapeutic usefulness of OCA was demonstrated by an ARR of 0.08, RRR of 0.25 and NNT of 12 to avoid further surgical treatment. The total costs of adhesive applications and reoperations were $US 14,809.00 and $US 158,538.50, respectively.ConclusionsThe results showed a similar success rate for both treatments. However, sealant use should be considered before surgical treatment because this is a simple outpatient procedure with a reasonable success rate.Trial registrationClinicalTrials.gov Identifier: NCT02115191. Date: April 13, 2014.

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“…Many surgical techniques, as well as dressing models, were identified in the treatment of hypospadias [1][2][3][4]. An ideal dressing for hypospadias should be easy to apply and remove.…”

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confidence: 99%

Dressing or Not after Tubularized Incised Plate Urethroplasty

2021

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Background: Many surgical techniques, as well as dressing models, were identified in the treatment of hypospadias. There are many publications in the literature that are the result of the effort to find the ideal dressing after hypospadias surgery. The dressing has some benefits; however, it has some adverse effects. The present study aimed to discuss outcomes of the patients who have been operated through the tubularized incised plate urethroplasty (TIPU) method and followed with and without dressing postoperatively. Methods: Patients operated on through the TIPU method between March 2015 and August 2019 were reviewed retrospectively. The patients were divided into two groups, dressing and undressing. Preoperative hypospadias severity was evaluated according to the Glans-Urethral Meatus-Shaft (GMS) scoring method. The care results of the patients were recorded. Postoperative outcomes were compared according to the Hypospadias Objective Scoring Evaluation (HOSE) scale, and statistical analyses were conducted. The results of both groups were compared statistically. Results: One hundred and nineteen patients were divided into two groups: dressing (n = 56) and nondressing (n = 63). The patients’ average age was 3.54 ± 2.97 years in group 1 and 3.50 ± 3.01 years in group 2 (p = 0.940). There was not any statistically significant difference between the two groups for demographic data. Minimal bleeding had stopped in three patients in the nondressing group spontaneously before discharging. No severe edema or hematoma, which might have concerned the parents, appeared. Two (3.5%) and 3 (4.7%) patients underwent a maximum of three urethral dilation sessions in dressing and nondressing groups, respectively (p = 0.556). We found no significant difference between groups in the comparison of preoperative GMS and postoperative HOSE scoring. Discussion: The most important limitation of the study is that it is retrospective. Pre- and postoperative scoring systems are objective. The data obtained in the literature show that surgeons prefer to apply dressings commonly after the TIPU technique. Advantages and disadvantages of dressing are mentioned in the literature. Even if the paradigm is dressing in hypospadias surgery, according to the results of our study, dressing may not affect the functional and cosmetic results of TIPU repair. Conclusion: Postoperative functional and cosmetic results of TIPU in hypospadias appear to be independent of dressing. However, the results must be supported by further research.

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Cyanoacrylate glue dressing for hypospadias surgery

Cited by 16 publications

References 10 publications

Experimental study on the chemico-physical interaction between a two-component cyanoacrylate glue and the material of PICCs

Experimental study on the chemico-physical interaction between a two-component cyanoacrylate glue and the material of PICCs

2-octyl cyanoacrylate versus reintervention for closure of urethrocutaneous fistulae after urethroplasty for hypospadias: a randomized controlled trial

Dressing or Not after Tubularized Incised Plate Urethroplasty

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